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Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice.

Woldbye, D P D; Nanobashvili, Avtandil LU ; Husum, H; Bolwig, T G and Kokaia, Merab LU (2002) In Neuroscience Letters 333(2). p.127-130
Abstract
Previous studies show that neuropeptide Y (NPY) inhibits in vitro seizures in rodent hippocampus. Here, we explored the effect of NPY application on epileptiform discharges induced by perfusion with magnesium-free solution in slices of entorhinal cortex from two different mouse strains. NPY significantly reduced the duration of epileptiform discharges with a peak effect of 36–50%. This is the first study showing anti-epileptiform effect of NPY in the entorhinal cortex and also the first evidence that NPY inhibits seizures in a cortical region in mice. The entorhinal cortex has a central role in transferring information between the hippocampus and the rest of the brain. Therefore our data further strengthen the concept of NPY and its... (More)
Previous studies show that neuropeptide Y (NPY) inhibits in vitro seizures in rodent hippocampus. Here, we explored the effect of NPY application on epileptiform discharges induced by perfusion with magnesium-free solution in slices of entorhinal cortex from two different mouse strains. NPY significantly reduced the duration of epileptiform discharges with a peak effect of 36–50%. This is the first study showing anti-epileptiform effect of NPY in the entorhinal cortex and also the first evidence that NPY inhibits seizures in a cortical region in mice. The entorhinal cortex has a central role in transferring information between the hippocampus and the rest of the brain. Therefore our data further strengthen the concept of NPY and its receptors as widespread regulators of epileptiform activity and as a potential future target for antiepileptic therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Neuropeptide Y, Epilepsy, Zero magnesium, Brain slice model, Mouse, Entorhinal cortex
in
Neuroscience Letters
volume
333
issue
2
pages
127 - 130
publisher
Elsevier
external identifiers
  • pmid:12419497
  • wos:000179431000013
  • scopus:0037159590
ISSN
0304-3940
DOI
10.1016/S0304-3940(02)01024-8
language
English
LU publication?
yes
id
dac419a6-4ac3-4f70-a19f-df8fd698eae2 (old id 111300)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12419497&dopt=Abstract
date added to LUP
2007-06-26 13:23:09
date last changed
2017-01-01 05:16:21
@article{dac419a6-4ac3-4f70-a19f-df8fd698eae2,
  abstract     = {Previous studies show that neuropeptide Y (NPY) inhibits in vitro seizures in rodent hippocampus. Here, we explored the effect of NPY application on epileptiform discharges induced by perfusion with magnesium-free solution in slices of entorhinal cortex from two different mouse strains. NPY significantly reduced the duration of epileptiform discharges with a peak effect of 36–50%. This is the first study showing anti-epileptiform effect of NPY in the entorhinal cortex and also the first evidence that NPY inhibits seizures in a cortical region in mice. The entorhinal cortex has a central role in transferring information between the hippocampus and the rest of the brain. Therefore our data further strengthen the concept of NPY and its receptors as widespread regulators of epileptiform activity and as a potential future target for antiepileptic therapy.},
  author       = {Woldbye, D P D and Nanobashvili, Avtandil and Husum, H and Bolwig, T G and Kokaia, Merab},
  issn         = {0304-3940},
  keyword      = {Neuropeptide Y,Epilepsy,Zero magnesium,Brain slice model,Mouse,Entorhinal cortex},
  language     = {eng},
  number       = {2},
  pages        = {127--130},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice.},
  url          = {http://dx.doi.org/10.1016/S0304-3940(02)01024-8},
  volume       = {333},
  year         = {2002},
}