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Impaction of cancellous bone grafts impairs osteoconduction in titanium chambers

Tägil, Magnus LU and Aspenberg, Per LU (1998) In Clinical Orthopaedics and Related Research 352. p.231-238
Abstract
The method of using morselized compacted cancellous allografts for hip arthroplasty revision shows results that seem to differ dramatically from other kinds of allografting. In structural cancellous allografts, bone ingrowth usually is limited to 2 to 3 mm, whereas morselized compacted grafts seem to be remodeled totally in several cases, as judged by radiography. In the current study, impacted cancellous allografts were compared with unimpacted allografts. Seventeen rats had a bone conduction chamber implanted in the tibias bilaterally. On one side the chambers contained an impacted graft (bone volume fraction 65%) and on the contralateral side an unimpacted graft (bone volume fraction 35%). Impaction of the grafts was done preoperatively... (More)
The method of using morselized compacted cancellous allografts for hip arthroplasty revision shows results that seem to differ dramatically from other kinds of allografting. In structural cancellous allografts, bone ingrowth usually is limited to 2 to 3 mm, whereas morselized compacted grafts seem to be remodeled totally in several cases, as judged by radiography. In the current study, impacted cancellous allografts were compared with unimpacted allografts. Seventeen rats had a bone conduction chamber implanted in the tibias bilaterally. On one side the chambers contained an impacted graft (bone volume fraction 65%) and on the contralateral side an unimpacted graft (bone volume fraction 35%). Impaction of the grafts was done preoperatively with a pressure of either 25 or 2500 MPa. Ingrowing bone could enter the cylindrical interior of the chamber only at one end. After 6 weeks the mean distance the ingrown bone had reached into the graft was measured on histologic slides. With both impaction pressures, the bone ingrowth distance was decreased to 30% of the unimpacted controls. It appears that impaction alone does not have a favorable effect on the osteoconductive properties of a bone graft. On the contrary, impaction seems to disfavor osteoconduction. However, in the clinical situation this is not necessarily a disadvantage. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Orthopaedics and Related Research
volume
352
pages
231 - 238
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:9678052
  • scopus:0042759714
ISSN
0009-921X
language
English
LU publication?
yes
id
ec6b472e-9f23-45bd-9309-bd253ff3b61b (old id 1113097)
date added to LUP
2008-07-14 11:50:43
date last changed
2017-01-01 05:17:57
@article{ec6b472e-9f23-45bd-9309-bd253ff3b61b,
  abstract     = {The method of using morselized compacted cancellous allografts for hip arthroplasty revision shows results that seem to differ dramatically from other kinds of allografting. In structural cancellous allografts, bone ingrowth usually is limited to 2 to 3 mm, whereas morselized compacted grafts seem to be remodeled totally in several cases, as judged by radiography. In the current study, impacted cancellous allografts were compared with unimpacted allografts. Seventeen rats had a bone conduction chamber implanted in the tibias bilaterally. On one side the chambers contained an impacted graft (bone volume fraction 65%) and on the contralateral side an unimpacted graft (bone volume fraction 35%). Impaction of the grafts was done preoperatively with a pressure of either 25 or 2500 MPa. Ingrowing bone could enter the cylindrical interior of the chamber only at one end. After 6 weeks the mean distance the ingrown bone had reached into the graft was measured on histologic slides. With both impaction pressures, the bone ingrowth distance was decreased to 30% of the unimpacted controls. It appears that impaction alone does not have a favorable effect on the osteoconductive properties of a bone graft. On the contrary, impaction seems to disfavor osteoconduction. However, in the clinical situation this is not necessarily a disadvantage.},
  author       = {Tägil, Magnus and Aspenberg, Per},
  issn         = {0009-921X},
  language     = {eng},
  pages        = {231--238},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Clinical Orthopaedics and Related Research},
  title        = {Impaction of cancellous bone grafts impairs osteoconduction in titanium chambers},
  volume       = {352},
  year         = {1998},
}