Inhibition of angiotensin II-induced contraction by losartan in human coronary arteries
Holmgren, Anton ; Pantev, Emil LU ; Erlinge, David LU
and Edvinsson, Lars
LU
(1998)
In Journal of Cardiovascular Pharmacology
32(4).
p.662-664
- Abstract
- The in vitro effects of angiotensin II (Ang II) in human vessels are not well studied. The development of specific Ang II-receptor antagonists has made it possible to delineate more carefully the receptor mechanisms involved. The objective of this study was twofold: to investigate the effect of Ang II on human coronary arteries and to study the effects of angiotensin II type 1 receptor blockade with losartan. The setting was contractile experiments with ring segments of coronary arteries. We observed that Ang II is a vasoconstrictor of human coronary arteries, with a pEC50 value of 9.26 +/- 0.22 and Emax of 68.7 +/- 9.61% of potassium-induced contraction. Losartan (10-100 nM) shifted the concentration-response curve of Ang II to the right,... (More)
- The in vitro effects of angiotensin II (Ang II) in human vessels are not well studied. The development of specific Ang II-receptor antagonists has made it possible to delineate more carefully the receptor mechanisms involved. The objective of this study was twofold: to investigate the effect of Ang II on human coronary arteries and to study the effects of angiotensin II type 1 receptor blockade with losartan. The setting was contractile experiments with ring segments of coronary arteries. We observed that Ang II is a vasoconstrictor of human coronary arteries, with a pEC50 value of 9.26 +/- 0.22 and Emax of 68.7 +/- 9.61% of potassium-induced contraction. Losartan (10-100 nM) shifted the concentration-response curve of Ang II to the right, with pEC50 values of 7.64 +/- 0.10 and 7.00 +/- 0.15, respectively (p = 0.001), demonstrating the antagonistic properties of losartan. We also noted a decreased maximal response to Ang II after incubation of losartan, with Emax of 51.1 +/- 7.08% and 41.9 +/- 4.70% (p = 0.05), respectively. In conclusion, this is the first report describing the contractile effect of Ang II and the antagonizing effects of losartan in isolated human coronary arteries. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1113109
- author
- Holmgren, Anton
; Pantev, Emil
LU
; Erlinge, David
LU
and Edvinsson, Lars
LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Cardiovascular Pharmacology
- volume
- 32
- issue
- 4
- pages
- 662 - 664
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:9781937
- scopus:0031691836
- ISSN
- 1533-4023
- language
- English
- LU publication?
- yes
- id
- 8dba5fe5-f18d-4c8f-857b-145d7d297fbf (old id 1113109)
- date added to LUP
- 2016-04-01 11:54:09
- date last changed
- 2024-10-08 14:15:28
@article{8dba5fe5-f18d-4c8f-857b-145d7d297fbf,
abstract = {{The in vitro effects of angiotensin II (Ang II) in human vessels are not well studied. The development of specific Ang II-receptor antagonists has made it possible to delineate more carefully the receptor mechanisms involved. The objective of this study was twofold: to investigate the effect of Ang II on human coronary arteries and to study the effects of angiotensin II type 1 receptor blockade with losartan. The setting was contractile experiments with ring segments of coronary arteries. We observed that Ang II is a vasoconstrictor of human coronary arteries, with a pEC50 value of 9.26 +/- 0.22 and Emax of 68.7 +/- 9.61% of potassium-induced contraction. Losartan (10-100 nM) shifted the concentration-response curve of Ang II to the right, with pEC50 values of 7.64 +/- 0.10 and 7.00 +/- 0.15, respectively (p = 0.001), demonstrating the antagonistic properties of losartan. We also noted a decreased maximal response to Ang II after incubation of losartan, with Emax of 51.1 +/- 7.08% and 41.9 +/- 4.70% (p = 0.05), respectively. In conclusion, this is the first report describing the contractile effect of Ang II and the antagonizing effects of losartan in isolated human coronary arteries.}},
author = {{Holmgren, Anton and Pantev, Emil and Erlinge, David and Edvinsson, Lars}},
issn = {{1533-4023}},
language = {{eng}},
number = {{4}},
pages = {{662--664}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Cardiovascular Pharmacology}},
title = {{Inhibition of angiotensin II-induced contraction by losartan in human coronary arteries}},
volume = {{32}},
year = {{1998}},
}