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Pregnancy in Parkinson's disease: a review of the literature and a case report

Hagell, Peter LU ; Odin, P and Vinge, Ellen LU (1998) In Movement Disorders 13(1). p.34-38
Abstract
Pregnancy is rare in Parkinson's disease (PD). In the literature on studies of antiparkinsonian drugs in animals during pregnancy, there are reports on malformations of the skeletal and circulatory system. However, the majority of studies in animals have not shown any teratogenicity. Amantadine has been teratogenic in rats and selegiline has caused neurochemical and behavioral alterations in rats when coadministered with clorgyline. The published experience with humans consists of 35 pregnancies among 26 women suffering from PD, including this report, and a number of cases treated with antiparkinsonian agents for other reasons. With the exception of the majority of the cases where amantadine was used, complications have been rare. However,... (More)
Pregnancy is rare in Parkinson's disease (PD). In the literature on studies of antiparkinsonian drugs in animals during pregnancy, there are reports on malformations of the skeletal and circulatory system. However, the majority of studies in animals have not shown any teratogenicity. Amantadine has been teratogenic in rats and selegiline has caused neurochemical and behavioral alterations in rats when coadministered with clorgyline. The published experience with humans consists of 35 pregnancies among 26 women suffering from PD, including this report, and a number of cases treated with antiparkinsonian agents for other reasons. With the exception of the majority of the cases where amantadine was used, complications have been rare. However, there are indications that suggest a possible risk of a woman's parkinsonism worsening in connection with pregnancy. We also report the case of a woman with PD who was treated with L-dopa-benserazide during an uncomplicated pregnancy and gave birth to a healthy boy without experiencing any worsening of her PD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Parkinson's disease, Pregnancy, Levodopa, Dopamine agonists, Selegiline, Dopa decarboxylase inhibitors
in
Movement Disorders
volume
13
issue
1
pages
34 - 38
publisher
John Wiley & Sons
external identifiers
  • pmid:9452323
  • scopus:0031985411
ISSN
0885-3185
DOI
10.1002/mds.870130110
language
English
LU publication?
yes
id
1a88a471-8118-45de-bfbc-4cfa4c856d04 (old id 1113319)
date added to LUP
2008-07-14 16:25:22
date last changed
2017-11-12 03:25:24
@article{1a88a471-8118-45de-bfbc-4cfa4c856d04,
  abstract     = {Pregnancy is rare in Parkinson's disease (PD). In the literature on studies of antiparkinsonian drugs in animals during pregnancy, there are reports on malformations of the skeletal and circulatory system. However, the majority of studies in animals have not shown any teratogenicity. Amantadine has been teratogenic in rats and selegiline has caused neurochemical and behavioral alterations in rats when coadministered with clorgyline. The published experience with humans consists of 35 pregnancies among 26 women suffering from PD, including this report, and a number of cases treated with antiparkinsonian agents for other reasons. With the exception of the majority of the cases where amantadine was used, complications have been rare. However, there are indications that suggest a possible risk of a woman's parkinsonism worsening in connection with pregnancy. We also report the case of a woman with PD who was treated with L-dopa-benserazide during an uncomplicated pregnancy and gave birth to a healthy boy without experiencing any worsening of her PD.},
  author       = {Hagell, Peter and Odin, P and Vinge, Ellen},
  issn         = {0885-3185},
  keyword      = {Parkinson's disease,Pregnancy,Levodopa,Dopamine agonists,Selegiline,Dopa decarboxylase inhibitors},
  language     = {eng},
  number       = {1},
  pages        = {34--38},
  publisher    = {John Wiley & Sons},
  series       = {Movement Disorders},
  title        = {Pregnancy in Parkinson's disease: a review of the literature and a case report},
  url          = {http://dx.doi.org/10.1002/mds.870130110},
  volume       = {13},
  year         = {1998},
}