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Effect of environmental and clinical factors on lung function and respiratory symptoms in adolescents with alpha1-antitrypsin deficiency

Piitulainen, Eeva LU and Sveger, Tomas LU (1998) In Acta Pædiatrica 87(11). p.1120-1124
Abstract
Individuals identified in the Swedish neonatal alpha1-antitrypsin (AAT) screening study were followed prospectively from their first to their eighteenth year of life. The aim of this study was to analyse the effect of environmental factors, i.e. active and passive smoking, and of clinical factors on lung function and the occurrence of respiratory symptoms in AAT-deficient adolescents. The study group consisted of 88 protease inhibitor (Pi)ZZ and 40 PiSZ adolescents. Medical history including respiratory symptoms, and active and passive smoking were recorded at each follow-up up to the age of 18 y. Lung function tests were performed at the present check-up. At the age of 18 y, both forced expiratory volume in one second (FEV ) and... (More)
Individuals identified in the Swedish neonatal alpha1-antitrypsin (AAT) screening study were followed prospectively from their first to their eighteenth year of life. The aim of this study was to analyse the effect of environmental factors, i.e. active and passive smoking, and of clinical factors on lung function and the occurrence of respiratory symptoms in AAT-deficient adolescents. The study group consisted of 88 protease inhibitor (Pi)ZZ and 40 PiSZ adolescents. Medical history including respiratory symptoms, and active and passive smoking were recorded at each follow-up up to the age of 18 y. Lung function tests were performed at the present check-up. At the age of 18 y, both forced expiratory volume in one second (FEV ) and FEV1/vital capacity (VC) were significantly lower in the smoking than in the non-smoking subgroup, and significantly more smokers than non-smokers reported the presence of phlegm. The mean FEV1/VC ratio was lower for those presently exposed to parental smoking. Multiple linear regression analysis indicated that clinical liver disease in early life, active smoking and parental smoking were independent determinants of FEV1/VC. The results suggest that marginal deviations in lung function and the symptom of phlegm among AAT-deficient adolescents occur characteristically early in the subgroup of smokers. Parental smoking may contribute to decreased lung function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, a1-antitrypsin deficiency, emphysema, passive smoking, smoking
in
Acta Pædiatrica
volume
87
issue
11
pages
1120 - 1124
publisher
Taylor & Francis
external identifiers
  • pmid:9846912
ISSN
1651-2227
DOI
10.1080/080352598750031095
language
English
LU publication?
yes
id
2e9bbe4d-3319-42ed-a0c8-6931ab11e1e9 (old id 1113611)
date added to LUP
2008-07-15 13:26:34
date last changed
2016-04-16 03:18:06
@article{2e9bbe4d-3319-42ed-a0c8-6931ab11e1e9,
  abstract     = {Individuals identified in the Swedish neonatal alpha1-antitrypsin (AAT) screening study were followed prospectively from their first to their eighteenth year of life. The aim of this study was to analyse the effect of environmental factors, i.e. active and passive smoking, and of clinical factors on lung function and the occurrence of respiratory symptoms in AAT-deficient adolescents. The study group consisted of 88 protease inhibitor (Pi)ZZ and 40 PiSZ adolescents. Medical history including respiratory symptoms, and active and passive smoking were recorded at each follow-up up to the age of 18 y. Lung function tests were performed at the present check-up. At the age of 18 y, both forced expiratory volume in one second (FEV ) and FEV1/vital capacity (VC) were significantly lower in the smoking than in the non-smoking subgroup, and significantly more smokers than non-smokers reported the presence of phlegm. The mean FEV1/VC ratio was lower for those presently exposed to parental smoking. Multiple linear regression analysis indicated that clinical liver disease in early life, active smoking and parental smoking were independent determinants of FEV1/VC. The results suggest that marginal deviations in lung function and the symptom of phlegm among AAT-deficient adolescents occur characteristically early in the subgroup of smokers. Parental smoking may contribute to decreased lung function.},
  author       = {Piitulainen, Eeva and Sveger, Tomas},
  issn         = {1651-2227},
  keyword      = {Adolescent,a1-antitrypsin deficiency,emphysema,passive smoking,smoking},
  language     = {eng},
  number       = {11},
  pages        = {1120--1124},
  publisher    = {Taylor & Francis},
  series       = {Acta Pædiatrica},
  title        = {Effect of environmental and clinical factors on lung function and respiratory symptoms in adolescents with alpha1-antitrypsin deficiency},
  url          = {http://dx.doi.org/10.1080/080352598750031095},
  volume       = {87},
  year         = {1998},
}