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Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to low birth weight

Rylander, Lars LU ; Strömberg, Ulf LU ; Dyremark, Eva; Ostman, Conny; Nilsson-Ehle, Peter LU and Hagmar, Lars (1998) In American Journal of Epidemiology 147(5). p.493-502
Abstract
The authors examined the hypothesized association between the body burden of polychlorinated biphenyls (PCB) in women and the risk of low birth weight for their infants. In Sweden, a main exposure route for PCBs and other persistent organochlorine compounds is through the consumption of fatty fish from the Baltic Sea (on the Swedish east coast). A previous comparison between a cohort of consumers of large quantities of fish from the Swedish east coast and a reference population, together with a following analysis based on questionnaire data from a case-control study within the east coast cohort, supported the hypothesized association. In 1995, blood samples were collected from the wives and ex-wives of fishermen from the Swedish east coast... (More)
The authors examined the hypothesized association between the body burden of polychlorinated biphenyls (PCB) in women and the risk of low birth weight for their infants. In Sweden, a main exposure route for PCBs and other persistent organochlorine compounds is through the consumption of fatty fish from the Baltic Sea (on the Swedish east coast). A previous comparison between a cohort of consumers of large quantities of fish from the Swedish east coast and a reference population, together with a following analysis based on questionnaire data from a case-control study within the east coast cohort, supported the hypothesized association. In 1995, blood samples were collected from the wives and ex-wives of fishermen from the Swedish east coast (n = 192) who had given birth during the period 1973-1991. Cases (n = 57), i.e., infants with low birth weight (1,500-2,750 g), were matched with controls (n = 135; birth weight, 3,250-4,500 g) on gender, parity, and calendar year of birth. The concentration of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma was analyzed; it has been suggested that CB-153 is a relevant biomarker of exposure to PCBs. The concentration of CB-153 in the plasma of mothers during the year of childbirth was "estimated" using some alternative plausible kinetic models. For two alternative estimated exposure datasets, which were focused on separately, an increase in the risk of a low birth weight was observed at a CB-153 concentration of 300 and 400 ng/g lipid weight, respectively (adjusted odds ratios of 2.1 (95% confidence interval (CI) 1.0-4.7) and 2.3 (95% CI 0.9-5.9)). The present results strengthen the findings reported previously for this study population. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
eating, fish, birth weight, polychlorinated biphenyis
in
American Journal of Epidemiology
volume
147
issue
5
pages
493 - 502
publisher
Oxford University Press
external identifiers
  • pmid:9525537
  • scopus:2642594053
ISSN
0002-9262
language
English
LU publication?
yes
id
96087a9c-3898-43fd-b7f1-c1ddc468b281 (old id 1113760)
alternative location
http://aje.oxfordjournals.org/cgi/reprint/147/5/493
date added to LUP
2008-07-16 11:01:12
date last changed
2017-08-06 03:52:11
@article{96087a9c-3898-43fd-b7f1-c1ddc468b281,
  abstract     = {The authors examined the hypothesized association between the body burden of polychlorinated biphenyls (PCB) in women and the risk of low birth weight for their infants. In Sweden, a main exposure route for PCBs and other persistent organochlorine compounds is through the consumption of fatty fish from the Baltic Sea (on the Swedish east coast). A previous comparison between a cohort of consumers of large quantities of fish from the Swedish east coast and a reference population, together with a following analysis based on questionnaire data from a case-control study within the east coast cohort, supported the hypothesized association. In 1995, blood samples were collected from the wives and ex-wives of fishermen from the Swedish east coast (n = 192) who had given birth during the period 1973-1991. Cases (n = 57), i.e., infants with low birth weight (1,500-2,750 g), were matched with controls (n = 135; birth weight, 3,250-4,500 g) on gender, parity, and calendar year of birth. The concentration of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma was analyzed; it has been suggested that CB-153 is a relevant biomarker of exposure to PCBs. The concentration of CB-153 in the plasma of mothers during the year of childbirth was "estimated" using some alternative plausible kinetic models. For two alternative estimated exposure datasets, which were focused on separately, an increase in the risk of a low birth weight was observed at a CB-153 concentration of 300 and 400 ng/g lipid weight, respectively (adjusted odds ratios of 2.1 (95% confidence interval (CI) 1.0-4.7) and 2.3 (95% CI 0.9-5.9)). The present results strengthen the findings reported previously for this study population.},
  author       = {Rylander, Lars and Strömberg, Ulf and Dyremark, Eva and Ostman, Conny and Nilsson-Ehle, Peter and Hagmar, Lars},
  issn         = {0002-9262},
  keyword      = {eating,fish,birth weight,polychlorinated biphenyis},
  language     = {eng},
  number       = {5},
  pages        = {493--502},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to low birth weight},
  volume       = {147},
  year         = {1998},
}