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Plasma-derived proteins in airway defence, disease and repair of epithelial injury

Persson, Carl LU ; Erjefält, Jonas LU ; Greiff, Lennart LU ; Andersson, M; Erjefalt, I; Godfrey, R W; Korsgren, Magnus LU ; Linden, M; Sundler, Frank LU and Svensson, Christer LU (1998) In European Respiratory Journal 11(4). p.958-970
Abstract
One significant characteristic of the airway mucosa in vivo, that cannot easily be mimicked in vitro, is its microcirculation, which generates a highly dynamic, biologically active milieu of plasma-derived molecules that may pass to the airway lumen in vivo. New data on the mechanisms of airway mucosal exudation indicate that the protein systems of circulating plasma may contribute significantly to the biology and immunology of the lamina propria, its surface epithelium and the luminal surface, not only in injured airways, but also in airways that are activated but display no sign of oedema, epithelial disruption, or increased absorption capacity. We suggest that present knowledge of the mechanisms of plasma exudation, together with... (More)
One significant characteristic of the airway mucosa in vivo, that cannot easily be mimicked in vitro, is its microcirculation, which generates a highly dynamic, biologically active milieu of plasma-derived molecules that may pass to the airway lumen in vivo. New data on the mechanisms of airway mucosal exudation indicate that the protein systems of circulating plasma may contribute significantly to the biology and immunology of the lamina propria, its surface epithelium and the luminal surface, not only in injured airways, but also in airways that are activated but display no sign of oedema, epithelial disruption, or increased absorption capacity. We suggest that present knowledge of the mechanisms of plasma exudation, together with rapidly emerging information (not detailed herein) on receptors, target cells and cellular responses to the plasma-derived molecules, must be considered in any realistic model that investigates "immuno-inflammatory" mechanisms of the airway mucosa. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
plasma proteins, Mucosal biology in vivo, plasma exudation
in
European Respiratory Journal
volume
11
issue
4
pages
958 - 970
publisher
Eur Respiratory Soc
external identifiers
  • pmid:9623704
  • scopus:14444278046
ISSN
1399-3003
language
English
LU publication?
yes
id
56659a11-bffa-40e1-95b1-81cc992cda0d (old id 1113959)
alternative location
http://erj.ersjournals.com/cgi/reprint/11/4/958
date added to LUP
2008-07-16 14:24:45
date last changed
2017-08-13 03:35:59
@article{56659a11-bffa-40e1-95b1-81cc992cda0d,
  abstract     = {One significant characteristic of the airway mucosa in vivo, that cannot easily be mimicked in vitro, is its microcirculation, which generates a highly dynamic, biologically active milieu of plasma-derived molecules that may pass to the airway lumen in vivo. New data on the mechanisms of airway mucosal exudation indicate that the protein systems of circulating plasma may contribute significantly to the biology and immunology of the lamina propria, its surface epithelium and the luminal surface, not only in injured airways, but also in airways that are activated but display no sign of oedema, epithelial disruption, or increased absorption capacity. We suggest that present knowledge of the mechanisms of plasma exudation, together with rapidly emerging information (not detailed herein) on receptors, target cells and cellular responses to the plasma-derived molecules, must be considered in any realistic model that investigates "immuno-inflammatory" mechanisms of the airway mucosa.},
  author       = {Persson, Carl and Erjefält, Jonas and Greiff, Lennart and Andersson, M and Erjefalt, I and Godfrey, R W and Korsgren, Magnus and Linden, M and Sundler, Frank and Svensson, Christer},
  issn         = {1399-3003},
  keyword      = {plasma proteins,Mucosal biology in vivo,plasma exudation},
  language     = {eng},
  number       = {4},
  pages        = {958--970},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal},
  title        = {Plasma-derived proteins in airway defence, disease and repair of epithelial injury},
  volume       = {11},
  year         = {1998},
}