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Protein H, an antiphagocytic surface protein in Streptococcus pyogenes

Kihlberg, B M; Collin, Mattias LU ; Olsén, Arne LU and Björck, Lars LU (1999) In Infection and Immunity 67(4). p.1708-1714
Abstract
Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mutants were generated that expressed only one or none of these proteins at the bacterial surface. For survival in human blood either protein H or M1 protein was sufficient, whereas the double mutant was rapidly killed. The protein-binding properties of protein H, M1 protein, and the mutants suggest that bacterial binding of immunoglobulin G and factor... (More)
Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mutants were generated that expressed only one or none of these proteins at the bacterial surface. For survival in human blood either protein H or M1 protein was sufficient, whereas the double mutant was rapidly killed. The protein-binding properties of protein H, M1 protein, and the mutants suggest that bacterial binding of immunoglobulin G and factor H or factor H-like protein 1, which are regulatory proteins in the complement system, contribute to the antiphagocytic property. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
67
issue
4
pages
1708 - 1714
publisher
American Society for Microbiology
external identifiers
  • pmid:10085008
  • scopus:0033063964
ISSN
1098-5522
language
English
LU publication?
yes
id
a26209b0-3cf6-41e7-a0ad-e062ce399cfc (old id 1114106)
alternative location
http://iai.asm.org/cgi/content/full/67/4/1708
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC96518/
date added to LUP
2008-07-03 13:29:32
date last changed
2017-07-19 15:35:45
@article{a26209b0-3cf6-41e7-a0ad-e062ce399cfc,
  abstract     = {Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mutants were generated that expressed only one or none of these proteins at the bacterial surface. For survival in human blood either protein H or M1 protein was sufficient, whereas the double mutant was rapidly killed. The protein-binding properties of protein H, M1 protein, and the mutants suggest that bacterial binding of immunoglobulin G and factor H or factor H-like protein 1, which are regulatory proteins in the complement system, contribute to the antiphagocytic property.},
  author       = {Kihlberg, B M and Collin, Mattias and Olsén, Arne and Björck, Lars},
  issn         = {1098-5522},
  language     = {eng},
  number       = {4},
  pages        = {1708--1714},
  publisher    = {American Society for Microbiology},
  series       = {Infection and Immunity},
  title        = {Protein H, an antiphagocytic surface protein in Streptococcus pyogenes},
  volume       = {67},
  year         = {1999},
}