Assessment of glioma viability by estimating 201Tl SPET tumour uptake volume
(1999) In Nuclear Medicine Communications 20(9). p.837-844- Abstract
- The aim of this study was to develop a quantitative method to assess viable tumour based on post-operative 201Tl single photon emission tomography (SPET). We studied 15 patients with histologically defined highly malignant gliomas in the post-operative phase before initiation of adjuvant treatment. A 201Tl index was calculated in two ways: maximal counts versus mean counts within a region of interest (ROI). The tumour uptake volume (TUV) within the lesion was calculated from the number of voxels that had 201Tl uptake above a threshold calculated from the uptake on the contralateral side. The threshold was set at three levels: A = 1.4 times the mean 201Tl uptake in a three-dimensional reference ROI + 96.7% confidence interval (the TUV was... (More)
- The aim of this study was to develop a quantitative method to assess viable tumour based on post-operative 201Tl single photon emission tomography (SPET). We studied 15 patients with histologically defined highly malignant gliomas in the post-operative phase before initiation of adjuvant treatment. A 201Tl index was calculated in two ways: maximal counts versus mean counts within a region of interest (ROI). The tumour uptake volume (TUV) within the lesion was calculated from the number of voxels that had 201Tl uptake above a threshold calculated from the uptake on the contralateral side. The threshold was set at three levels: A = 1.4 times the mean 201Tl uptake in a three-dimensional reference ROI + 96.7% confidence interval (the TUV was corrected by subtraction of the volume in the reference ROI that had uptake above the threshold with compensation for unequal ROI sizes); B = 1.4 times the mean reference ROI + 99% confidence interval; and C = maximum 201Tl uptake in the reference ROI. The SPET results were compared with the tumour volumes calculated from CT scans. Thirteen tumours showed high post-operative 201Tl uptake. The 201Tl index was not significantly correlated with histological grade within the group of highly malignant gliomas. 201Tl SPET tumour uptake volume method B was highly significantly correlated with CT estimated tumour volume. In conclusion, the measurement of post-operative 201Tl SPET tumour uptake volume demonstrates metabolically active glioma tissue and is an alternative method for the monitoring of glioma treatment response. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114418
- author
- Källén, Kristina LU ; Geijer, Bo LU ; Andersson, Ann-Margret LU ; Holtås, Stig LU ; Ryding, Erik LU and Rosén, Ingmar LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nuclear Medicine Communications
- volume
- 20
- issue
- 9
- pages
- 837 - 844
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:10533190
- scopus:17944383513
- ISSN
- 1473-5628
- language
- English
- LU publication?
- yes
- id
- cc5262f1-a2d0-4c5f-a2f0-487fd718be57 (old id 1114418)
- date added to LUP
- 2016-04-01 12:20:03
- date last changed
- 2022-01-27 02:12:48
@article{cc5262f1-a2d0-4c5f-a2f0-487fd718be57, abstract = {{The aim of this study was to develop a quantitative method to assess viable tumour based on post-operative 201Tl single photon emission tomography (SPET). We studied 15 patients with histologically defined highly malignant gliomas in the post-operative phase before initiation of adjuvant treatment. A 201Tl index was calculated in two ways: maximal counts versus mean counts within a region of interest (ROI). The tumour uptake volume (TUV) within the lesion was calculated from the number of voxels that had 201Tl uptake above a threshold calculated from the uptake on the contralateral side. The threshold was set at three levels: A = 1.4 times the mean 201Tl uptake in a three-dimensional reference ROI + 96.7% confidence interval (the TUV was corrected by subtraction of the volume in the reference ROI that had uptake above the threshold with compensation for unequal ROI sizes); B = 1.4 times the mean reference ROI + 99% confidence interval; and C = maximum 201Tl uptake in the reference ROI. The SPET results were compared with the tumour volumes calculated from CT scans. Thirteen tumours showed high post-operative 201Tl uptake. The 201Tl index was not significantly correlated with histological grade within the group of highly malignant gliomas. 201Tl SPET tumour uptake volume method B was highly significantly correlated with CT estimated tumour volume. In conclusion, the measurement of post-operative 201Tl SPET tumour uptake volume demonstrates metabolically active glioma tissue and is an alternative method for the monitoring of glioma treatment response.}}, author = {{Källén, Kristina and Geijer, Bo and Andersson, Ann-Margret and Holtås, Stig and Ryding, Erik and Rosén, Ingmar}}, issn = {{1473-5628}}, language = {{eng}}, number = {{9}}, pages = {{837--844}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Nuclear Medicine Communications}}, title = {{Assessment of glioma viability by estimating 201Tl SPET tumour uptake volume}}, volume = {{20}}, year = {{1999}}, }