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Assessment of glioma viability by estimating 201Tl SPET tumour uptake volume

Källén, Kristina LU ; Geijer, Bo LU ; Andersson, Ann-Margret LU ; Holtås, Stig LU ; Ryding, Erik LU and Rosén, Ingmar LU (1999) In Nuclear Medicine Communications 20(9). p.837-844
Abstract
The aim of this study was to develop a quantitative method to assess viable tumour based on post-operative 201Tl single photon emission tomography (SPET). We studied 15 patients with histologically defined highly malignant gliomas in the post-operative phase before initiation of adjuvant treatment. A 201Tl index was calculated in two ways: maximal counts versus mean counts within a region of interest (ROI). The tumour uptake volume (TUV) within the lesion was calculated from the number of voxels that had 201Tl uptake above a threshold calculated from the uptake on the contralateral side. The threshold was set at three levels: A = 1.4 times the mean 201Tl uptake in a three-dimensional reference ROI + 96.7% confidence interval (the TUV was... (More)
The aim of this study was to develop a quantitative method to assess viable tumour based on post-operative 201Tl single photon emission tomography (SPET). We studied 15 patients with histologically defined highly malignant gliomas in the post-operative phase before initiation of adjuvant treatment. A 201Tl index was calculated in two ways: maximal counts versus mean counts within a region of interest (ROI). The tumour uptake volume (TUV) within the lesion was calculated from the number of voxels that had 201Tl uptake above a threshold calculated from the uptake on the contralateral side. The threshold was set at three levels: A = 1.4 times the mean 201Tl uptake in a three-dimensional reference ROI + 96.7% confidence interval (the TUV was corrected by subtraction of the volume in the reference ROI that had uptake above the threshold with compensation for unequal ROI sizes); B = 1.4 times the mean reference ROI + 99% confidence interval; and C = maximum 201Tl uptake in the reference ROI. The SPET results were compared with the tumour volumes calculated from CT scans. Thirteen tumours showed high post-operative 201Tl uptake. The 201Tl index was not significantly correlated with histological grade within the group of highly malignant gliomas. 201Tl SPET tumour uptake volume method B was highly significantly correlated with CT estimated tumour volume. In conclusion, the measurement of post-operative 201Tl SPET tumour uptake volume demonstrates metabolically active glioma tissue and is an alternative method for the monitoring of glioma treatment response. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nuclear Medicine Communications
volume
20
issue
9
pages
837 - 844
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:10533190
  • scopus:17944383513
ISSN
1473-5628
language
English
LU publication?
yes
id
cc5262f1-a2d0-4c5f-a2f0-487fd718be57 (old id 1114418)
date added to LUP
2008-07-04 09:56:05
date last changed
2017-10-01 03:52:43
@article{cc5262f1-a2d0-4c5f-a2f0-487fd718be57,
  abstract     = {The aim of this study was to develop a quantitative method to assess viable tumour based on post-operative 201Tl single photon emission tomography (SPET). We studied 15 patients with histologically defined highly malignant gliomas in the post-operative phase before initiation of adjuvant treatment. A 201Tl index was calculated in two ways: maximal counts versus mean counts within a region of interest (ROI). The tumour uptake volume (TUV) within the lesion was calculated from the number of voxels that had 201Tl uptake above a threshold calculated from the uptake on the contralateral side. The threshold was set at three levels: A = 1.4 times the mean 201Tl uptake in a three-dimensional reference ROI + 96.7% confidence interval (the TUV was corrected by subtraction of the volume in the reference ROI that had uptake above the threshold with compensation for unequal ROI sizes); B = 1.4 times the mean reference ROI + 99% confidence interval; and C = maximum 201Tl uptake in the reference ROI. The SPET results were compared with the tumour volumes calculated from CT scans. Thirteen tumours showed high post-operative 201Tl uptake. The 201Tl index was not significantly correlated with histological grade within the group of highly malignant gliomas. 201Tl SPET tumour uptake volume method B was highly significantly correlated with CT estimated tumour volume. In conclusion, the measurement of post-operative 201Tl SPET tumour uptake volume demonstrates metabolically active glioma tissue and is an alternative method for the monitoring of glioma treatment response.},
  author       = {Källén, Kristina and Geijer, Bo and Andersson, Ann-Margret and Holtås, Stig and Ryding, Erik and Rosén, Ingmar},
  issn         = {1473-5628},
  language     = {eng},
  number       = {9},
  pages        = {837--844},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Nuclear Medicine Communications},
  title        = {Assessment of glioma viability by estimating 201Tl SPET tumour uptake volume},
  volume       = {20},
  year         = {1999},
}