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Substance P relaxes rat bronchial smooth muscle via epithelial prostanoid synthesis

Bodelsson, Mikael LU ; Blomquist, Sten LU ; Caverius, Kaj and Tornebrandt, Kenneth (1999) In Respiration 66(4). p.355-359
Abstract
BACKGROUND: Substance P is present in bronchial nerve fibres. The physiological actions of substance P are mediated via tachykinin NK(1) receptors. Immunochemical studies have demonstrated tachykinin NK(1) receptors in the rat airway epithelium. OBJECTIVE: To elucidate how epithelial tachykinin NK(1) receptors affect smooth muscle response to substance P. METHODS: Contractile response of isolated rat bronchial trunk with or without epithelium was recorded. RESULTS: In intact segments precontracted by 5-hydroxytryptamine, relaxation was induced by substance P and the nitric oxide donor, sodium nitroprusside. Removal of the epithelium abolished relaxation induced by substance P but did not affect relaxation induced by sodium nitroprusside.... (More)
BACKGROUND: Substance P is present in bronchial nerve fibres. The physiological actions of substance P are mediated via tachykinin NK(1) receptors. Immunochemical studies have demonstrated tachykinin NK(1) receptors in the rat airway epithelium. OBJECTIVE: To elucidate how epithelial tachykinin NK(1) receptors affect smooth muscle response to substance P. METHODS: Contractile response of isolated rat bronchial trunk with or without epithelium was recorded. RESULTS: In intact segments precontracted by 5-hydroxytryptamine, relaxation was induced by substance P and the nitric oxide donor, sodium nitroprusside. Removal of the epithelium abolished relaxation induced by substance P but did not affect relaxation induced by sodium nitroprusside. The cyclo-oxygenase inhibitor, indomethacin, but not the nitric oxide synthase inhibitor, L-N(G)-monomethylarginine, reduced the relaxation in response to substance P. CONCLUSIONS: Epithelial tachykinin NK(1) receptors mediate substance-P-induced relaxation of rat bronchial smooth muscle via release of prostanoids but not nitric oxide. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bronchi, Epithelium, Indomethacin, Nitric oxide, Serotonin, Substance P
in
Respiration
volume
66
issue
4
pages
355 - 359
publisher
Karger
external identifiers
  • pmid:10461085
  • scopus:0032780769
ISSN
1423-0356
DOI
10.1159/000029407
language
English
LU publication?
yes
id
cc6dee7d-85ee-4ba7-957a-b9291726270e (old id 1114544)
date added to LUP
2008-07-04 12:34:39
date last changed
2017-01-01 07:16:46
@article{cc6dee7d-85ee-4ba7-957a-b9291726270e,
  abstract     = {BACKGROUND: Substance P is present in bronchial nerve fibres. The physiological actions of substance P are mediated via tachykinin NK(1) receptors. Immunochemical studies have demonstrated tachykinin NK(1) receptors in the rat airway epithelium. OBJECTIVE: To elucidate how epithelial tachykinin NK(1) receptors affect smooth muscle response to substance P. METHODS: Contractile response of isolated rat bronchial trunk with or without epithelium was recorded. RESULTS: In intact segments precontracted by 5-hydroxytryptamine, relaxation was induced by substance P and the nitric oxide donor, sodium nitroprusside. Removal of the epithelium abolished relaxation induced by substance P but did not affect relaxation induced by sodium nitroprusside. The cyclo-oxygenase inhibitor, indomethacin, but not the nitric oxide synthase inhibitor, L-N(G)-monomethylarginine, reduced the relaxation in response to substance P. CONCLUSIONS: Epithelial tachykinin NK(1) receptors mediate substance-P-induced relaxation of rat bronchial smooth muscle via release of prostanoids but not nitric oxide.},
  author       = {Bodelsson, Mikael and Blomquist, Sten and Caverius, Kaj and Tornebrandt, Kenneth},
  issn         = {1423-0356},
  keyword      = {Bronchi,Epithelium,Indomethacin,Nitric oxide,Serotonin,Substance P},
  language     = {eng},
  number       = {4},
  pages        = {355--359},
  publisher    = {Karger},
  series       = {Respiration},
  title        = {Substance P relaxes rat bronchial smooth muscle via epithelial prostanoid synthesis},
  url          = {http://dx.doi.org/10.1159/000029407},
  volume       = {66},
  year         = {1999},
}