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Cytogenetic aberrations in Ewing sarcoma: are secondary changes associated with clinical outcome?

Kullendorff, Carl-Magnus LU ; Mertens, Fredrik LU ; Donner, M; Wiebe, Thomas LU ; Åkerman, Måns LU and Mandahl, Nils LU (1999) In Medical and Pediatric Oncology 32(2). p.79-83
Abstract
BACKGROUND: Ewing sarcoma is associated with a nonrandom pattern of primary and secondary chromosomal aberrations. Whereas the finding of rearrangements of chromosome 22, usually in the form of a balanced translocation t(11;22)(q24;q12), is important diagnostically, nothing is known about the potential prognostic impact of the secondary chromosomal aberrations. PROCEDURE: During a 1 3-year-period, short-term cultured tumor samples from 21 children and young adults with Ewing sarcoma were cytogenetically analyzed successfully. RESULTS: Clonal chromosome aberrations were detected in 18 patients, 17 of whom had the characteristic t(11;22)(q24;q12) or variants thereof. The most frequent secondary change was +8, followed by +12, +2, +5, +9,... (More)
BACKGROUND: Ewing sarcoma is associated with a nonrandom pattern of primary and secondary chromosomal aberrations. Whereas the finding of rearrangements of chromosome 22, usually in the form of a balanced translocation t(11;22)(q24;q12), is important diagnostically, nothing is known about the potential prognostic impact of the secondary chromosomal aberrations. PROCEDURE: During a 1 3-year-period, short-term cultured tumor samples from 21 children and young adults with Ewing sarcoma were cytogenetically analyzed successfully. RESULTS: Clonal chromosome aberrations were detected in 18 patients, 17 of whom had the characteristic t(11;22)(q24;q12) or variants thereof. The most frequent secondary change was +8, followed by +12, +2, +5, +9, +15, and gain of material from the long and short arms of chromosome 1. The only recurrent secondary change that was restricted to tumors from the ten patients that were dead at latest follow-up was gain of 1q material. Furthermore, all three patients with tumors with chromosome numbers over 50 had died, and the only patient with a tumor karyotype lacking chromosome 22 rearrangement was alive without evidence of disease. CONCLUSIONS: These data and previously published results indicate that the karyotypic pattern not only may be of diagnostic significance but also may be important prognostically. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chromosome aberration, Ewing sarcoma, cytogenetics, clinical outcome
in
Medical and Pediatric Oncology
volume
32
issue
2
pages
79 - 83
publisher
John Wiley & Sons
external identifiers
  • pmid:9950192
  • scopus:0032922316
ISSN
1096-911X
DOI
10.1002/(SICI)1096-911X(199902)32:2<79::AID-MPO1>3.0.CO;2-R
language
English
LU publication?
yes
id
1cefbe7f-c828-488e-a53d-db61244d5d64 (old id 1114558)
date added to LUP
2008-07-04 13:40:24
date last changed
2017-07-30 03:45:02
@article{1cefbe7f-c828-488e-a53d-db61244d5d64,
  abstract     = {BACKGROUND: Ewing sarcoma is associated with a nonrandom pattern of primary and secondary chromosomal aberrations. Whereas the finding of rearrangements of chromosome 22, usually in the form of a balanced translocation t(11;22)(q24;q12), is important diagnostically, nothing is known about the potential prognostic impact of the secondary chromosomal aberrations. PROCEDURE: During a 1 3-year-period, short-term cultured tumor samples from 21 children and young adults with Ewing sarcoma were cytogenetically analyzed successfully. RESULTS: Clonal chromosome aberrations were detected in 18 patients, 17 of whom had the characteristic t(11;22)(q24;q12) or variants thereof. The most frequent secondary change was +8, followed by +12, +2, +5, +9, +15, and gain of material from the long and short arms of chromosome 1. The only recurrent secondary change that was restricted to tumors from the ten patients that were dead at latest follow-up was gain of 1q material. Furthermore, all three patients with tumors with chromosome numbers over 50 had died, and the only patient with a tumor karyotype lacking chromosome 22 rearrangement was alive without evidence of disease. CONCLUSIONS: These data and previously published results indicate that the karyotypic pattern not only may be of diagnostic significance but also may be important prognostically.},
  author       = {Kullendorff, Carl-Magnus and Mertens, Fredrik and Donner, M and Wiebe, Thomas and Åkerman, Måns and Mandahl, Nils},
  issn         = {1096-911X},
  keyword      = {chromosome aberration,Ewing sarcoma,cytogenetics,clinical outcome},
  language     = {eng},
  number       = {2},
  pages        = {79--83},
  publisher    = {John Wiley & Sons},
  series       = {Medical and Pediatric Oncology},
  title        = {Cytogenetic aberrations in Ewing sarcoma: are secondary changes associated with clinical outcome?},
  url          = {http://dx.doi.org/10.1002/(SICI)1096-911X(199902)32:2<79::AID-MPO1>3.0.CO;2-R},
  volume       = {32},
  year         = {1999},
}