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Selective increase of the contractile response to endothelin-1 in subcutaneous arteries from patients with essential hypertension

Lind, Henrik; Adner, Mikael LU ; Erlinge, David LU ; Brunkwall, Jan and Edvinsson, Lars LU (1999) In Blood Pressure 8(1). p.9-15
Abstract
Endothelin-1 has been shown to contribute to basal vascular tone in man. Since endothelin-1 is a potent vasoconstrictor putatively involved in hypertension, we have compared the contractile responses of endothelin-1 and noradrenaline in relation to potassium chloride in subcutaneous resistance arteries from subjects with established essential hypertension with matched controls. Furthermore, with RT-PCR, the occurrence of mRNA for the ETA and ET(B) receptors was shown in the tunica media layer of subcutaneous arteries in controls and hypertensives. The maximum contractile response to endothelin-1 was significantly higher in the subcutaneous arteries of the hypertensives (by 88% with no change in potency) as compared to controls. The... (More)
Endothelin-1 has been shown to contribute to basal vascular tone in man. Since endothelin-1 is a potent vasoconstrictor putatively involved in hypertension, we have compared the contractile responses of endothelin-1 and noradrenaline in relation to potassium chloride in subcutaneous resistance arteries from subjects with established essential hypertension with matched controls. Furthermore, with RT-PCR, the occurrence of mRNA for the ETA and ET(B) receptors was shown in the tunica media layer of subcutaneous arteries in controls and hypertensives. The maximum contractile response to endothelin-1 was significantly higher in the subcutaneous arteries of the hypertensives (by 88% with no change in potency) as compared to controls. The responses to noradrenaline, acetylcholine and potassium chloride did not differ between the groups. This selective increase in the contractile response to endothelin-1 might contribute to the development of essential hypertension. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acetylcholine, endothelin-1, essential hypertension, noradrenaline, potassium
in
Blood Pressure
volume
8
issue
1
pages
9 - 15
publisher
Taylor & Francis
external identifiers
  • pmid:10412877
  • scopus:0033029044
ISSN
0803-7051
DOI
10.1080/080370599439742
language
English
LU publication?
yes
id
00e09ff3-d899-4859-82f2-bab2f96c7ab2 (old id 1114827)
date added to LUP
2008-07-07 09:05:32
date last changed
2017-01-01 04:42:42
@article{00e09ff3-d899-4859-82f2-bab2f96c7ab2,
  abstract     = {Endothelin-1 has been shown to contribute to basal vascular tone in man. Since endothelin-1 is a potent vasoconstrictor putatively involved in hypertension, we have compared the contractile responses of endothelin-1 and noradrenaline in relation to potassium chloride in subcutaneous resistance arteries from subjects with established essential hypertension with matched controls. Furthermore, with RT-PCR, the occurrence of mRNA for the ETA and ET(B) receptors was shown in the tunica media layer of subcutaneous arteries in controls and hypertensives. The maximum contractile response to endothelin-1 was significantly higher in the subcutaneous arteries of the hypertensives (by 88% with no change in potency) as compared to controls. The responses to noradrenaline, acetylcholine and potassium chloride did not differ between the groups. This selective increase in the contractile response to endothelin-1 might contribute to the development of essential hypertension.},
  author       = {Lind, Henrik and Adner, Mikael and Erlinge, David and Brunkwall, Jan and Edvinsson, Lars},
  issn         = {0803-7051},
  keyword      = {acetylcholine,endothelin-1,essential
hypertension,noradrenaline,potassium},
  language     = {eng},
  number       = {1},
  pages        = {9--15},
  publisher    = {Taylor & Francis},
  series       = {Blood Pressure},
  title        = {Selective increase of the contractile response to endothelin-1 in subcutaneous arteries from patients with essential hypertension},
  url          = {http://dx.doi.org/10.1080/080370599439742},
  volume       = {8},
  year         = {1999},
}