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Environmental influence on gene expression and recovery from cerebral ischemia

Johansson, Barbro LU ; Zhao, L and Mattsson, Bengt LU (1999) In Acta Neurochirurgica. Supplementum 73. p.51-55
Abstract
An emerging concept in neurobiology is that the adult brain retains a capacity for plasticity and functional reorganization throughout the life span. Experimental data from electrophysiological, morphological and behavioral studies have documented experience dependent plasticity in the intact and injured adult brain. Neuroimaging clinical studies indicate altered post stroke functional activation patterns, usually including activation of the intact hemisphere. However, there is some disagreement regarding their functional significance and longitudinal studies correlating outcome and activation pattern are needed to solve some controversies. Postoperative housing of rats in activity stimulating environment after ligation of the middle... (More)
An emerging concept in neurobiology is that the adult brain retains a capacity for plasticity and functional reorganization throughout the life span. Experimental data from electrophysiological, morphological and behavioral studies have documented experience dependent plasticity in the intact and injured adult brain. Neuroimaging clinical studies indicate altered post stroke functional activation patterns, usually including activation of the intact hemisphere. However, there is some disagreement regarding their functional significance and longitudinal studies correlating outcome and activation pattern are needed to solve some controversies. Postoperative housing of rats in activity stimulating environment after ligation of the middle cerebral artery significantly enhances outcome. Gene expression for brain derived neurotrophic factor and Ca2+/calmodulin-dependent protein kinase II, two substances with potential role in brain plasticity, show different patterns in animals housed in standard and in enriched environment. The functional significance of altered gene expression needs to be evaluated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Neurochirurgica. Supplementum
volume
73
pages
51 - 55
publisher
Springer
external identifiers
  • pmid:10494341
  • scopus:0032612842
ISSN
0065-1419
language
English
LU publication?
yes
id
20547a03-b692-4cfd-a486-880eff1eb028 (old id 1115175)
date added to LUP
2008-07-07 15:17:24
date last changed
2017-10-01 04:44:50
@article{20547a03-b692-4cfd-a486-880eff1eb028,
  abstract     = {An emerging concept in neurobiology is that the adult brain retains a capacity for plasticity and functional reorganization throughout the life span. Experimental data from electrophysiological, morphological and behavioral studies have documented experience dependent plasticity in the intact and injured adult brain. Neuroimaging clinical studies indicate altered post stroke functional activation patterns, usually including activation of the intact hemisphere. However, there is some disagreement regarding their functional significance and longitudinal studies correlating outcome and activation pattern are needed to solve some controversies. Postoperative housing of rats in activity stimulating environment after ligation of the middle cerebral artery significantly enhances outcome. Gene expression for brain derived neurotrophic factor and Ca2+/calmodulin-dependent protein kinase II, two substances with potential role in brain plasticity, show different patterns in animals housed in standard and in enriched environment. The functional significance of altered gene expression needs to be evaluated.},
  author       = {Johansson, Barbro and Zhao, L and Mattsson, Bengt},
  issn         = {0065-1419},
  language     = {eng},
  pages        = {51--55},
  publisher    = {Springer},
  series       = {Acta Neurochirurgica. Supplementum},
  title        = {Environmental influence on gene expression and recovery from cerebral ischemia},
  volume       = {73},
  year         = {1999},
}