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Environmental enrichment alters nerve growth factor-induced gene A and glucocorticoid receptor messenger RNA expression after middle cerebral artery occlusion in rats

Dahlqvist, P; Zhao, L; Johansson, I M; Mattsson, Bengt LU ; Johansson, Barbro LU ; Seckl, J R and Olsson, T (1999) In Neuroscience 93(2). p.527-535
Abstract
Housing rats in an enriched environment after focal brain ischemia improves functional outcome without changes in infarct volume, suggesting neuroplastic changes outside the lesion. In this study, permanent occlusion of the middle cerebral artery was followed by housing in an enriched or a standard environment. Nerve growth factor-induced gene A and glucocorticoid receptor messenger RNA expression were determined by in situ hybridization two to 30 days after middle cerebral artery occlusion. Stroke induced a decrease in nerve growth factor-induced gene A messenger RNA expression in cortical areas outside the ischemic lesion and in the CA1 subregion of the hippocampus two to three days after ischemia. This decrease was more prolonged with... (More)
Housing rats in an enriched environment after focal brain ischemia improves functional outcome without changes in infarct volume, suggesting neuroplastic changes outside the lesion. In this study, permanent occlusion of the middle cerebral artery was followed by housing in an enriched or a standard environment. Nerve growth factor-induced gene A and glucocorticoid receptor messenger RNA expression were determined by in situ hybridization two to 30 days after middle cerebral artery occlusion. Stroke induced a decrease in nerve growth factor-induced gene A messenger RNA expression in cortical areas outside the ischemic lesion and in the CA1 subregion of the hippocampus two to three days after ischemia. This decrease was more prolonged with environmental enrichment, lasting until 20 days. However, 30 days after focal cerebral ischemia, environmental enrichment increased nerve growth factor-induced gene A expression compared to standard housing. A reduction of hippocampal glucocorticoid receptor (type II) messenger RNA two to 12 days after stroke in standard housed rats was restored by environmental enrichment. These data suggest that improved functional outcome induced by environmental enrichment after middle cerebral artery occlusion is associated with dynamically altered expression of nerve growth factor-induced gene A messenger RNA in brain regions outside the ischemic lesion, and sustained levels of hippocampal glucocorticoid receptor messenger RNA expression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
focal cerebral ischemia, enriched environment, spontaneously hypertensive rats, transcription factors, NGFI-A, glucocorticoid receptors
in
Neuroscience
volume
93
issue
2
pages
527 - 535
publisher
Elsevier
external identifiers
  • pmid:10465436
  • scopus:0032787896
ISSN
1873-7544
DOI
10.1016/S0306-4522(99)00183-9
language
English
LU publication?
yes
id
37733add-e024-43fa-a465-c2ce5f0bc3c3 (old id 1115178)
date added to LUP
2008-07-07 15:19:40
date last changed
2017-01-01 04:20:20
@article{37733add-e024-43fa-a465-c2ce5f0bc3c3,
  abstract     = {Housing rats in an enriched environment after focal brain ischemia improves functional outcome without changes in infarct volume, suggesting neuroplastic changes outside the lesion. In this study, permanent occlusion of the middle cerebral artery was followed by housing in an enriched or a standard environment. Nerve growth factor-induced gene A and glucocorticoid receptor messenger RNA expression were determined by in situ hybridization two to 30 days after middle cerebral artery occlusion. Stroke induced a decrease in nerve growth factor-induced gene A messenger RNA expression in cortical areas outside the ischemic lesion and in the CA1 subregion of the hippocampus two to three days after ischemia. This decrease was more prolonged with environmental enrichment, lasting until 20 days. However, 30 days after focal cerebral ischemia, environmental enrichment increased nerve growth factor-induced gene A expression compared to standard housing. A reduction of hippocampal glucocorticoid receptor (type II) messenger RNA two to 12 days after stroke in standard housed rats was restored by environmental enrichment. These data suggest that improved functional outcome induced by environmental enrichment after middle cerebral artery occlusion is associated with dynamically altered expression of nerve growth factor-induced gene A messenger RNA in brain regions outside the ischemic lesion, and sustained levels of hippocampal glucocorticoid receptor messenger RNA expression.},
  author       = {Dahlqvist, P and Zhao, L and Johansson, I M and Mattsson, Bengt and Johansson, Barbro and Seckl, J R and Olsson, T},
  issn         = {1873-7544},
  keyword      = {focal cerebral ischemia,enriched environment,spontaneously hypertensive rats,transcription factors,NGFI-A,glucocorticoid receptors},
  language     = {eng},
  number       = {2},
  pages        = {527--535},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Environmental enrichment alters nerve growth factor-induced gene A and glucocorticoid receptor messenger RNA expression after middle cerebral artery occlusion in rats},
  url          = {http://dx.doi.org/10.1016/S0306-4522(99)00183-9},
  volume       = {93},
  year         = {1999},
}