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Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project

Bengtsson Boström, Kristina LU ; Orho-Melander, Marju LU ; Lindblad, Ulf LU ; Melander, Olle LU ; Bøg-Hansen, Erik LU ; Ranstam, Jonas LU ; Råstam, Lennart LU and Groop, Leif LU (1999) In Journal of Hypertension 17(11). p.1569-1575
Abstract
OBJECTIVE: To study the association between polymorphisms in the angiotensin converting enzyme (ACE) gene and angiotensinogen (AGT) gene and hypertension and/or type 2 diabetes in a community population. PATIENTS AND METHODS: The insertion (I)/deletion (D) polymorphism of the ACE gene and the M235T polymorphism of the AGT gene were genotyped in 773 nondiabetic individuals with hypertension, 193 normotensive patients with type 2 diabetes, 243 patients with type 2 diabetes and hypertension, and in 820 normotensive control individuals identified in a community-based study. RESULTS: The DD genotype was associated with hypertension in individuals less than 70 years [odds ratio (OR) = 1.54, confidence interval (CI) = 1.09-2.18] and remained so... (More)
OBJECTIVE: To study the association between polymorphisms in the angiotensin converting enzyme (ACE) gene and angiotensinogen (AGT) gene and hypertension and/or type 2 diabetes in a community population. PATIENTS AND METHODS: The insertion (I)/deletion (D) polymorphism of the ACE gene and the M235T polymorphism of the AGT gene were genotyped in 773 nondiabetic individuals with hypertension, 193 normotensive patients with type 2 diabetes, 243 patients with type 2 diabetes and hypertension, and in 820 normotensive control individuals identified in a community-based study. RESULTS: The DD genotype was associated with hypertension in individuals less than 70 years [odds ratio (OR) = 1.54, confidence interval (CI) = 1.09-2.18] and remained so when patients with type 2 diabetes were excluded from the analysis (OR = 1.45, CI = 1.01-2.09). The strongest association was with the combination of type 2 diabetes and hypertension (OR = 2.19, CI = 1.09-4.38). There was no association with type 2 diabetes without hypertension. No association was observed between the M235T variant or the 3'-microsatellite polymorphism of the AGT gene and hypertension. CONCLUSION: The D-allele of the ACE gene ID polymorphism increases susceptibility to hypertension, particularly when associated with type 2 diabetes. No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
Hypertension, Diabetes mellitus, Polymorphism, Peptidyl-dipeptidase A, Gene, Angiotensinogen, Genetic determinism, Human, Peptidyl-dipeptidases, Peptidases, Hydrolases, Enzyme, Cardiovascular disease, Endocrinopathy
in
Journal of Hypertension
volume
17
issue
11
pages
1569 - 1575
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:10608470
  • scopus:0032729521
ISSN
1473-5598
language
English
LU publication?
yes
id
27f1a250-95f8-4584-8a92-b94871dee36d (old id 1115649)
date added to LUP
2008-07-08 10:59:47
date last changed
2017-01-01 07:19:50
@article{27f1a250-95f8-4584-8a92-b94871dee36d,
  abstract     = {OBJECTIVE: To study the association between polymorphisms in the angiotensin converting enzyme (ACE) gene and angiotensinogen (AGT) gene and hypertension and/or type 2 diabetes in a community population. PATIENTS AND METHODS: The insertion (I)/deletion (D) polymorphism of the ACE gene and the M235T polymorphism of the AGT gene were genotyped in 773 nondiabetic individuals with hypertension, 193 normotensive patients with type 2 diabetes, 243 patients with type 2 diabetes and hypertension, and in 820 normotensive control individuals identified in a community-based study. RESULTS: The DD genotype was associated with hypertension in individuals less than 70 years [odds ratio (OR) = 1.54, confidence interval (CI) = 1.09-2.18] and remained so when patients with type 2 diabetes were excluded from the analysis (OR = 1.45, CI = 1.01-2.09). The strongest association was with the combination of type 2 diabetes and hypertension (OR = 2.19, CI = 1.09-4.38). There was no association with type 2 diabetes without hypertension. No association was observed between the M235T variant or the 3'-microsatellite polymorphism of the AGT gene and hypertension. CONCLUSION: The D-allele of the ACE gene ID polymorphism increases susceptibility to hypertension, particularly when associated with type 2 diabetes. No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.},
  author       = {Bengtsson Boström, Kristina and Orho-Melander, Marju and Lindblad, Ulf and Melander, Olle and Bøg-Hansen, Erik and Ranstam, Jonas and Råstam, Lennart and Groop, Leif},
  issn         = {1473-5598},
  keyword      = {Hypertension,Diabetes mellitus,Polymorphism,Peptidyl-dipeptidase A,Gene,Angiotensinogen,Genetic determinism,Human,Peptidyl-dipeptidases,Peptidases,Hydrolases,Enzyme,Cardiovascular disease,Endocrinopathy},
  language     = {eng},
  number       = {11},
  pages        = {1569--1575},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project},
  volume       = {17},
  year         = {1999},
}