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Effects of dopamine in lung-transplanted pigs at 32 degrees C

Roscher, Roger LU ; Ingemansson, Richard LU ; Algotsson, Lars LU ; Sjöberg, Trygve LU and Steen, Stig LU (1999) In Acta Anaesthesiologica Scandinavica 43(7). p.715-721
Abstract
BACKGROUND: We have used hypothermia successfully in patients with acute respiratory failure after lung transplantation. However, we have observed that dopamine may cause a substantial decrease in mean arterial pressure (MAP) in hypothermic subjects. Furthermore, a dopamine-induced increase in pulmonary vascular resistance (PVR) has been reported in the literature, and this could aggravate the increase in PVR which is often seen both in the early postoperative phase after lung transplantation, and during hypothermia. We thus hypothesized that dopamine would decrease MAP and increase PVR in hypothermic lung-transplanted subjects. METHODS: Left single lung transplantation combined with right pneumonectomy was performed in 6 pigs anesthetized... (More)
BACKGROUND: We have used hypothermia successfully in patients with acute respiratory failure after lung transplantation. However, we have observed that dopamine may cause a substantial decrease in mean arterial pressure (MAP) in hypothermic subjects. Furthermore, a dopamine-induced increase in pulmonary vascular resistance (PVR) has been reported in the literature, and this could aggravate the increase in PVR which is often seen both in the early postoperative phase after lung transplantation, and during hypothermia. We thus hypothesized that dopamine would decrease MAP and increase PVR in hypothermic lung-transplanted subjects. METHODS: Left single lung transplantation combined with right pneumonectomy was performed in 6 pigs anesthetized with ketamine and midazolam and muscle relaxed with pancuronium. After an observation period of 24 h, the effect of dopamine infused at 5 and 12 microg x kg(-1) x min(-1) was studied in normothermia (38 degrees C) and after cooling by cold-water immersion to 32 degrees C. RESULTS: Systemic vascular resistance index (SVRI) increased and cardiac index (CI) decreased in hypothermia. Dopamine decreased SVRI and increased CI, both in normothermia and at 32 degrees C. MAP decreased during infusion of dopamine in hypothermia. Dopamine had no effect on the pulmonary vascular resistance index (PVRI). CONCLUSION: The results suggest that dopamine may be used to increase cardiac output after lung transplantation in moderate hypothermia as well as in normothermia, but one should be aware that dopamine may cause a substantial decrease in blood pressure, depending on the prevailing hemodynamic conditions at the start of its administration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
opamine, hypothermia, inotropic drugs, in vivo, pig
in
Acta Anaesthesiologica Scandinavica
volume
43
issue
7
pages
715 - 721
publisher
Wiley-Blackwell
external identifiers
  • pmid:10456810
  • scopus:0032789232
ISSN
0001-5172
DOI
10.1034/j.1399-6576.1999.430705.x
language
English
LU publication?
yes
id
c97c620c-bd7d-418f-b64d-98e007683232 (old id 1115735)
date added to LUP
2008-07-08 13:13:21
date last changed
2017-01-01 04:22:10
@article{c97c620c-bd7d-418f-b64d-98e007683232,
  abstract     = {BACKGROUND: We have used hypothermia successfully in patients with acute respiratory failure after lung transplantation. However, we have observed that dopamine may cause a substantial decrease in mean arterial pressure (MAP) in hypothermic subjects. Furthermore, a dopamine-induced increase in pulmonary vascular resistance (PVR) has been reported in the literature, and this could aggravate the increase in PVR which is often seen both in the early postoperative phase after lung transplantation, and during hypothermia. We thus hypothesized that dopamine would decrease MAP and increase PVR in hypothermic lung-transplanted subjects. METHODS: Left single lung transplantation combined with right pneumonectomy was performed in 6 pigs anesthetized with ketamine and midazolam and muscle relaxed with pancuronium. After an observation period of 24 h, the effect of dopamine infused at 5 and 12 microg x kg(-1) x min(-1) was studied in normothermia (38 degrees C) and after cooling by cold-water immersion to 32 degrees C. RESULTS: Systemic vascular resistance index (SVRI) increased and cardiac index (CI) decreased in hypothermia. Dopamine decreased SVRI and increased CI, both in normothermia and at 32 degrees C. MAP decreased during infusion of dopamine in hypothermia. Dopamine had no effect on the pulmonary vascular resistance index (PVRI). CONCLUSION: The results suggest that dopamine may be used to increase cardiac output after lung transplantation in moderate hypothermia as well as in normothermia, but one should be aware that dopamine may cause a substantial decrease in blood pressure, depending on the prevailing hemodynamic conditions at the start of its administration.},
  author       = {Roscher, Roger and Ingemansson, Richard and Algotsson, Lars and Sjöberg, Trygve and Steen, Stig},
  issn         = {0001-5172},
  keyword      = {opamine,hypothermia,inotropic drugs,in vivo,pig},
  language     = {eng},
  number       = {7},
  pages        = {715--721},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Effects of dopamine in lung-transplanted pigs at 32 degrees C},
  url          = {http://dx.doi.org/10.1034/j.1399-6576.1999.430705.x},
  volume       = {43},
  year         = {1999},
}