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Cardiovascular effects of induced hypothermia after lung transplantation

Eriksson, Leif LU ; Roscher, Roger LU ; Ingemansson, Richard LU and Steen, Stig LU (1999) In Annals of Thoracic Surgery 67(3). p.804-809
Abstract
BACKGROUND: Induced hypothermia may be used to reduce metabolism in acute respiratory failure. Hypothermia is accompanied by an increase in pulmonary vascular resistance, as also seen in the early period after lung transplantation. It was our concern that the combination of the two would lead to an increased workload on the right ventricle. METHODS: To test this hypothesis we induced hypothermia to 32 degrees C in two groups of pigs. In one group we performed left single-lung transplantation combined with right pulmectomy (TRANSP group); in the other group, only right pulmectomy was performed (PULMEC group). RESULTS: During hypothermia, there was a significant increase in both groups in pulmonary vascular resistance (TRANSP group, 77%,... (More)
BACKGROUND: Induced hypothermia may be used to reduce metabolism in acute respiratory failure. Hypothermia is accompanied by an increase in pulmonary vascular resistance, as also seen in the early period after lung transplantation. It was our concern that the combination of the two would lead to an increased workload on the right ventricle. METHODS: To test this hypothesis we induced hypothermia to 32 degrees C in two groups of pigs. In one group we performed left single-lung transplantation combined with right pulmectomy (TRANSP group); in the other group, only right pulmectomy was performed (PULMEC group). RESULTS: During hypothermia, there was a significant increase in both groups in pulmonary vascular resistance (TRANSP group, 77%, p<0.05; PULMEC group, 54%, p<0.05) and a significant decrease in cardiac output (TRANSP group, 41%, p<0.05; PULMEC group, 34% p<0.05). Mean pulmonary artery pressure was unchanged, and the work done by the right ventricle was reduced (TRANSP group, 39%, p<0.05; PULMEC group, 31%). CONCLUSIONS: Induced hypothermia to 32 degrees C after lung transplantation resulted in a significant decrease in the work done by the right ventricle despite a significant increase in pulmonary vascular resistance. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Annals of Thoracic Surgery
volume
67
issue
3
pages
804 - 809
publisher
Elsevier
external identifiers
  • pmid:10215232
  • scopus:0032935989
ISSN
1552-6259
language
English
LU publication?
yes
id
4c1a8436-b87c-477b-b963-b1a98565caa2 (old id 1115881)
alternative location
http://ats.ctsnetjournals.org/cgi/content/full/67/3/804
date added to LUP
2008-07-08 15:45:35
date last changed
2017-01-01 04:20:06
@article{4c1a8436-b87c-477b-b963-b1a98565caa2,
  abstract     = {BACKGROUND: Induced hypothermia may be used to reduce metabolism in acute respiratory failure. Hypothermia is accompanied by an increase in pulmonary vascular resistance, as also seen in the early period after lung transplantation. It was our concern that the combination of the two would lead to an increased workload on the right ventricle. METHODS: To test this hypothesis we induced hypothermia to 32 degrees C in two groups of pigs. In one group we performed left single-lung transplantation combined with right pulmectomy (TRANSP group); in the other group, only right pulmectomy was performed (PULMEC group). RESULTS: During hypothermia, there was a significant increase in both groups in pulmonary vascular resistance (TRANSP group, 77%, p&lt;0.05; PULMEC group, 54%, p&lt;0.05) and a significant decrease in cardiac output (TRANSP group, 41%, p&lt;0.05; PULMEC group, 34% p&lt;0.05). Mean pulmonary artery pressure was unchanged, and the work done by the right ventricle was reduced (TRANSP group, 39%, p&lt;0.05; PULMEC group, 31%). CONCLUSIONS: Induced hypothermia to 32 degrees C after lung transplantation resulted in a significant decrease in the work done by the right ventricle despite a significant increase in pulmonary vascular resistance.},
  author       = {Eriksson, Leif and Roscher, Roger and Ingemansson, Richard and Steen, Stig},
  issn         = {1552-6259},
  language     = {eng},
  number       = {3},
  pages        = {804--809},
  publisher    = {Elsevier},
  series       = {Annals of Thoracic Surgery},
  title        = {Cardiovascular effects of induced hypothermia after lung transplantation},
  volume       = {67},
  year         = {1999},
}