Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery
(1999) In Gynecologic and Obstetric Investigation 47(2). p.102-107- Abstract
- The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2-methyl-5-HT. The effects of 5-HT and alpha-methyl-5-HT were antagonized by ketanserin, as well as methiothepin. The contractile effect of sumatriptan was antagonized by methiothepin but not by ketanserin. The 5-HT3 receptor antagonist, MDL 72222, did not affect the... (More)
- The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2-methyl-5-HT. The effects of 5-HT and alpha-methyl-5-HT were antagonized by ketanserin, as well as methiothepin. The contractile effect of sumatriptan was antagonized by methiothepin but not by ketanserin. The 5-HT3 receptor antagonist, MDL 72222, did not affect the contraction by any of the agonists, including 2-methyl-5-HT. It is concluded that the 5-HT-induced contraction in the circular smooth muscle of the human umbilical artery seems to be mediated by a mixed population of 5-HT1-like receptors and 5-HT2 receptors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1115885
- author
- Karlsson, Caroline LU ; Bodelsson, Gunilla LU ; Bodelsson, Mikael LU and Stjernquist, Martin LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Vascular smooth muscle, Umbilical artery, Serotonin, human, Receptor
- in
- Gynecologic and Obstetric Investigation
- volume
- 47
- issue
- 2
- pages
- 102 - 107
- publisher
- Karger
- external identifiers
-
- pmid:9949279
- scopus:0033038603
- ISSN
- 1423-002X
- DOI
- 10.1159/000010071
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Research Unit for Urogynaecology and Reproductive Pharmacology (013242710), Division of Infection Medicine (BMC) (013024020), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Preventive Paediatrics (013243030)
- id
- 91f94128-916e-41cd-a93c-667c91217202 (old id 1115885)
- date added to LUP
- 2016-04-01 11:43:36
- date last changed
- 2022-04-05 03:57:46
@article{91f94128-916e-41cd-a93c-667c91217202,
abstract = {{The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2-methyl-5-HT. The effects of 5-HT and alpha-methyl-5-HT were antagonized by ketanserin, as well as methiothepin. The contractile effect of sumatriptan was antagonized by methiothepin but not by ketanserin. The 5-HT3 receptor antagonist, MDL 72222, did not affect the contraction by any of the agonists, including 2-methyl-5-HT. It is concluded that the 5-HT-induced contraction in the circular smooth muscle of the human umbilical artery seems to be mediated by a mixed population of 5-HT1-like receptors and 5-HT2 receptors.}},
author = {{Karlsson, Caroline and Bodelsson, Gunilla and Bodelsson, Mikael and Stjernquist, Martin}},
issn = {{1423-002X}},
keywords = {{Vascular smooth muscle; Umbilical artery; Serotonin; human; Receptor}},
language = {{eng}},
number = {{2}},
pages = {{102--107}},
publisher = {{Karger}},
series = {{Gynecologic and Obstetric Investigation}},
title = {{Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery}},
url = {{http://dx.doi.org/10.1159/000010071}},
doi = {{10.1159/000010071}},
volume = {{47}},
year = {{1999}},
}