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Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery

Karlsson, Caroline LU ; Bodelsson, Gunilla LU ; Bodelsson, Mikael LU and Stjernquist, Martin LU (1999) In Gynecologic and Obstetric Investigation 47(2). p.102-107
Abstract
The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2-methyl-5-HT. The effects of 5-HT and alpha-methyl-5-HT were antagonized by ketanserin, as well as methiothepin. The contractile effect of sumatriptan was antagonized by methiothepin but not by ketanserin. The 5-HT3 receptor antagonist, MDL 72222, did not affect the... (More)
The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2-methyl-5-HT. The effects of 5-HT and alpha-methyl-5-HT were antagonized by ketanserin, as well as methiothepin. The contractile effect of sumatriptan was antagonized by methiothepin but not by ketanserin. The 5-HT3 receptor antagonist, MDL 72222, did not affect the contraction by any of the agonists, including 2-methyl-5-HT. It is concluded that the 5-HT-induced contraction in the circular smooth muscle of the human umbilical artery seems to be mediated by a mixed population of 5-HT1-like receptors and 5-HT2 receptors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Vascular smooth muscle, Umbilical artery, Serotonin, human, Receptor
in
Gynecologic and Obstetric Investigation
volume
47
issue
2
pages
102 - 107
publisher
Karger
external identifiers
  • pmid:9949279
  • scopus:0033038603
ISSN
1423-002X
DOI
10.1159/000010071
language
English
LU publication?
yes
id
91f94128-916e-41cd-a93c-667c91217202 (old id 1115885)
date added to LUP
2008-07-08 15:48:05
date last changed
2017-01-15 03:27:08
@article{91f94128-916e-41cd-a93c-667c91217202,
  abstract     = {The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2-methyl-5-HT. The effects of 5-HT and alpha-methyl-5-HT were antagonized by ketanserin, as well as methiothepin. The contractile effect of sumatriptan was antagonized by methiothepin but not by ketanserin. The 5-HT3 receptor antagonist, MDL 72222, did not affect the contraction by any of the agonists, including 2-methyl-5-HT. It is concluded that the 5-HT-induced contraction in the circular smooth muscle of the human umbilical artery seems to be mediated by a mixed population of 5-HT1-like receptors and 5-HT2 receptors.},
  author       = {Karlsson, Caroline and Bodelsson, Gunilla and Bodelsson, Mikael and Stjernquist, Martin},
  issn         = {1423-002X},
  keyword      = {Vascular smooth muscle,Umbilical artery,Serotonin,human,Receptor},
  language     = {eng},
  number       = {2},
  pages        = {102--107},
  publisher    = {Karger},
  series       = {Gynecologic and Obstetric Investigation},
  title        = {Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery},
  url          = {http://dx.doi.org/10.1159/000010071},
  volume       = {47},
  year         = {1999},
}