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Initial tests with a new cardiac assist device

Reitan, Öyvind LU ; Öhlin, Hans LU ; Peterzen, B; Granfeldt, H; Steen, Stig LU and Emanuelsson, H (1999) In ASAIO Journal 45(4). p.317-321
Abstract
Before, during, and after cardiac intervention, there is occasionally a need for circulatory support because of hemodynamic deterioration. For this purpose, a new minimally invasive cardiac assist device has been developed, and an early prototype has been studied in a bench test and in three pigs. The pump is a catheter system with a distal motor driven propeller (0-15,000 rpm) surrounded by a cage. The catheter was first tested in a tube in a water bath, where efficiency with respect to pressure generation and flow properties was measured. In the pig experiments, the pump was placed in the descending part of the aorta via a graft, and hemodynamic effects were recorded with three different propellers. The bench tests showed a velocity... (More)
Before, during, and after cardiac intervention, there is occasionally a need for circulatory support because of hemodynamic deterioration. For this purpose, a new minimally invasive cardiac assist device has been developed, and an early prototype has been studied in a bench test and in three pigs. The pump is a catheter system with a distal motor driven propeller (0-15,000 rpm) surrounded by a cage. The catheter was first tested in a tube in a water bath, where efficiency with respect to pressure generation and flow properties was measured. In the pig experiments, the pump was placed in the descending part of the aorta via a graft, and hemodynamic effects were recorded with three different propellers. The bench tests showed a velocity dependent pressure generation in the tube to the second power of the rpm, and 30 cm of water (> 22 mm Hg) could easily be achieved with all propellers. A pressure dependent flow in the tube was observed, with maximum flows of 20 L at 12,000 rpm and 27 L at 15,000 rpm. In the animal experiments, there was a velocity dependent mean pressure difference across the propeller, with up to 48 mm of mercury for the biggest propeller. An increase in cardiac output in all of the pigs was observed as well as a drop in pressure in the proximal part of the aorta. This study demonstrates the efficiency of this new device in vitro and in vivo. Hemodynamic changes are pronounced and are related to the speed and size of the propeller. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiocirculatory support, Device, Bench test, Non invasive method, Prototype, Animal, Pig, Artiodactyla, Ungulata, Mammalia, Vertebrata, Intensive cardiocirculatory care
in
ASAIO Journal
volume
45
issue
4
pages
317 - 321
publisher
Amercian Society of Artificial Internal Organs
external identifiers
  • pmid:10445738
  • scopus:0033490526
ISSN
1538-943X
language
English
LU publication?
yes
id
26eb0f43-d249-4ab3-9196-0bb324bb6426 (old id 1115968)
date added to LUP
2008-07-09 13:34:17
date last changed
2017-01-01 07:11:23
@article{26eb0f43-d249-4ab3-9196-0bb324bb6426,
  abstract     = {Before, during, and after cardiac intervention, there is occasionally a need for circulatory support because of hemodynamic deterioration. For this purpose, a new minimally invasive cardiac assist device has been developed, and an early prototype has been studied in a bench test and in three pigs. The pump is a catheter system with a distal motor driven propeller (0-15,000 rpm) surrounded by a cage. The catheter was first tested in a tube in a water bath, where efficiency with respect to pressure generation and flow properties was measured. In the pig experiments, the pump was placed in the descending part of the aorta via a graft, and hemodynamic effects were recorded with three different propellers. The bench tests showed a velocity dependent pressure generation in the tube to the second power of the rpm, and 30 cm of water (> 22 mm Hg) could easily be achieved with all propellers. A pressure dependent flow in the tube was observed, with maximum flows of 20 L at 12,000 rpm and 27 L at 15,000 rpm. In the animal experiments, there was a velocity dependent mean pressure difference across the propeller, with up to 48 mm of mercury for the biggest propeller. An increase in cardiac output in all of the pigs was observed as well as a drop in pressure in the proximal part of the aorta. This study demonstrates the efficiency of this new device in vitro and in vivo. Hemodynamic changes are pronounced and are related to the speed and size of the propeller.},
  author       = {Reitan, Öyvind and Öhlin, Hans and Peterzen, B and Granfeldt, H and Steen, Stig and Emanuelsson, H},
  issn         = {1538-943X},
  keyword      = {Cardiocirculatory support,Device,Bench test,Non invasive method,Prototype,Animal,Pig,Artiodactyla,Ungulata,Mammalia,Vertebrata,Intensive cardiocirculatory care},
  language     = {eng},
  number       = {4},
  pages        = {317--321},
  publisher    = {Amercian Society of Artificial Internal Organs},
  series       = {ASAIO Journal},
  title        = {Initial tests with a new cardiac assist device},
  volume       = {45},
  year         = {1999},
}