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Förmaksflimmer--epidemiologiska och elektrofysiologiska aspekter

Olsson, Bertil LU (1999) In Tidsskrift for Den Norske Lægeforening 119(11). p.1601-1604
Abstract (Swedish)
Förmaksflimmer är en vanlig och behandlingskrävande hjärtrytmrubbning. Det kroniska förmaksflimret finner man i befolkningen från 50-årsåldern i alltmer ökande omfattning. Antalet individer i Norge med denna rytmrubbning beräknas vara drygt 40000 och ökar med ytterligare cirka 5000 till år 2010. Mekanismerna bakom initiering och underhåll av förmaksflimmer kartläggs allt bättre. Den paroxysmala formen har i många fall ett fokalt ursprung, tillåtande kurativ terapi men kan också knytas till interatriala impulsledningsdefekter. Den kroniska formen fortgår bl.a. på grund av s.k. remodellering - en förkortad muskelrefraktäritet, orsakad av att den höga flimmerfrekvensen leder till en defekt intracellulär omsättning av Ca-joner. Pågående... (More)
Förmaksflimmer är en vanlig och behandlingskrävande hjärtrytmrubbning. Det kroniska förmaksflimret finner man i befolkningen från 50-årsåldern i alltmer ökande omfattning. Antalet individer i Norge med denna rytmrubbning beräknas vara drygt 40000 och ökar med ytterligare cirka 5000 till år 2010. Mekanismerna bakom initiering och underhåll av förmaksflimmer kartläggs allt bättre. Den paroxysmala formen har i många fall ett fokalt ursprung, tillåtande kurativ terapi men kan också knytas till interatriala impulsledningsdefekter. Den kroniska formen fortgår bl.a. på grund av s.k. remodellering - en förkortad muskelrefraktäritet, orsakad av att den höga flimmerfrekvensen leder till en defekt intracellulär omsättning av Ca-joner. Pågående studier förväntas bekräfta den kliniska nyttan av förbehandling med Ca-blockerare inför elregularisering av kroniskt förmaksflimmer. Den fortsatta återfallsfrekvensen är låg hos de patienter som kunnat bibehålla sinusrytm 1-2 månader efter regularisering. Detta innebär att antiarytmisk behandling möjligen endast behöver ges under begränsad tid efter regularisering, en fråga som måste belysas i vetenskapliga studier. (Less)
Abstract
Atrial fibrillation is a common and therapy-requiring cardiac arrhythmia. The chronic form becomes identified in population studies from the age of 50 and increases with age. The number of Norwegian individuals with this arrhythmia is estimated to be slightly in excess of 40,000 and it will increase approximately by another 5,000 until the year 2010. Mechanisms responsible for initiation and maintenance of the arrhythmia are increasingly better understood. The paroxysmal form often has a focal origin, allowing curative treatment, but can also be associated with signs of deficient interatrial conduction. The chronic form is perpetuated partly by a shortening of atrial myocardial refractoriness, attributed to a failure in the intracellular... (More)
Atrial fibrillation is a common and therapy-requiring cardiac arrhythmia. The chronic form becomes identified in population studies from the age of 50 and increases with age. The number of Norwegian individuals with this arrhythmia is estimated to be slightly in excess of 40,000 and it will increase approximately by another 5,000 until the year 2010. Mechanisms responsible for initiation and maintenance of the arrhythmia are increasingly better understood. The paroxysmal form often has a focal origin, allowing curative treatment, but can also be associated with signs of deficient interatrial conduction. The chronic form is perpetuated partly by a shortening of atrial myocardial refractoriness, attributed to a failure in the intracellular turnover of Ca-ions due to the high excitation rate. Ongoing studies are expected to illustrate the clinical benefit of Ca-blockers prior to cardioversion of chronic atrial fibrillation. The further relapse rate is low in patients who have maintained sinus rhythm more than 1-2 months following conversion. It is therefore possible that, following a successful conversion to sinus rhythm, aggressive antiarrhythmic treatment should be given during a limited period only--a strategy which has to be evaluated in prospective studies. (Less)
Please use this url to cite or link to this publication:
author
organization
alternative title
Atrial fibrillation--epidemiological and electrophysiological aspects
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arytmier, Epidemiologi, Hjerte, Behandling
in
Tidsskrift for Den Norske Lægeforening
volume
119
issue
11
pages
1601 - 1604
publisher
Norsk laegeforening
external identifiers
  • pmid:10385803
  • scopus:0033616928
ISSN
0029-2001
language
Swedish
LU publication?
yes
id
d15d3fc2-15fe-4c91-8808-1fc2027fc8b6 (old id 1116106)
alternative location
http://ww2.tidsskriftet.no/tsweb/199911/art6.html
date added to LUP
2008-07-09 15:35:38
date last changed
2017-01-01 07:13:59
@article{d15d3fc2-15fe-4c91-8808-1fc2027fc8b6,
  abstract     = {Atrial fibrillation is a common and therapy-requiring cardiac arrhythmia. The chronic form becomes identified in population studies from the age of 50 and increases with age. The number of Norwegian individuals with this arrhythmia is estimated to be slightly in excess of 40,000 and it will increase approximately by another 5,000 until the year 2010. Mechanisms responsible for initiation and maintenance of the arrhythmia are increasingly better understood. The paroxysmal form often has a focal origin, allowing curative treatment, but can also be associated with signs of deficient interatrial conduction. The chronic form is perpetuated partly by a shortening of atrial myocardial refractoriness, attributed to a failure in the intracellular turnover of Ca-ions due to the high excitation rate. Ongoing studies are expected to illustrate the clinical benefit of Ca-blockers prior to cardioversion of chronic atrial fibrillation. The further relapse rate is low in patients who have maintained sinus rhythm more than 1-2 months following conversion. It is therefore possible that, following a successful conversion to sinus rhythm, aggressive antiarrhythmic treatment should be given during a limited period only--a strategy which has to be evaluated in prospective studies.},
  author       = {Olsson, Bertil},
  issn         = {0029-2001},
  keyword      = {Arytmier,Epidemiologi,Hjerte,Behandling},
  language     = {swe},
  number       = {11},
  pages        = {1601--1604},
  publisher    = {Norsk laegeforening},
  series       = {Tidsskrift for Den Norske Lægeforening},
  title        = {Förmaksflimmer--epidemiologiska och elektrofysiologiska aspekter},
  volume       = {119},
  year         = {1999},
}