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Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system

Persson, Kristin LU ; Mörgelin, Matthias LU ; Lindbom, L; Alm, Per LU ; Björck, Lars LU and Herwald, Heiko LU (2000) In Journal of Experimental Medicine 192(10). p.1415-1424
Abstract
Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can lead to life-threatening complications. Here we report that activation of the contact system by Salmonella leads to massive infiltration of red blood cells and fibrin deposition in the lungs of infected rats. These pulmonary lesions were prevented when the infected animals were treated with H-D-Pro-Phe-Arg-chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bradykinin, factor XII, high molecular weight kininogen, plasma kallikrein, protease inhibitor
in
Journal of Experimental Medicine
volume
192
issue
10
pages
1415 - 1424
publisher
Rockefeller University Press
external identifiers
  • pmid:11085744
  • scopus:0034694027
ISSN
1540-9538
language
English
LU publication?
yes
id
2328cf15-8cd0-46dc-8105-444715833a28 (old id 1116236)
alternative location
http://www.jem.org/cgi/content/full/192/10/1415
date added to LUP
2008-07-01 10:45:45
date last changed
2017-01-01 06:39:24
@article{2328cf15-8cd0-46dc-8105-444715833a28,
  abstract     = {Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can lead to life-threatening complications. Here we report that activation of the contact system by Salmonella leads to massive infiltration of red blood cells and fibrin deposition in the lungs of infected rats. These pulmonary lesions were prevented when the infected animals were treated with H-D-Pro-Phe-Arg-chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease.},
  author       = {Persson, Kristin and Mörgelin, Matthias and Lindbom, L and Alm, Per and Björck, Lars and Herwald, Heiko},
  issn         = {1540-9538},
  keyword      = {bradykinin,factor XII,high molecular weight kininogen,plasma kallikrein,protease inhibitor},
  language     = {eng},
  number       = {10},
  pages        = {1415--1424},
  publisher    = {Rockefeller University Press},
  series       = {Journal of Experimental Medicine},
  title        = {Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system},
  volume       = {192},
  year         = {2000},
}