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T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines

Agace, William LU ; Higgins, J M; Sadasivan, B; Brenner, M B and Parker, C M (2000) In Current Opinion in Cell Biology 12(5). p.563-568
Abstract
The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin-... (More)
The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T cell, CD103, Lymphocyte, Chemokine, Homing, Epithelium, Cell adhesion, Cell adhesion molecule, Chemokine receptor, Alpha E
in
Current Opinion in Cell Biology
volume
12
issue
5
pages
563 - 568
publisher
Elsevier
external identifiers
  • pmid:10978890
  • scopus:0033822237
ISSN
0955-0674
DOI
10.1016/S0955-0674(00)00132-0
language
English
LU publication?
yes
id
f60f8fd2-fdd6-404b-9618-a811ef4f7cf3 (old id 1116326)
date added to LUP
2008-07-01 11:34:20
date last changed
2017-09-10 04:38:20
@article{f60f8fd2-fdd6-404b-9618-a811ef4f7cf3,
  abstract     = {The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites.},
  author       = {Agace, William and Higgins, J M and Sadasivan, B and Brenner, M B and Parker, C M},
  issn         = {0955-0674},
  keyword      = {T cell,CD103,Lymphocyte,Chemokine,Homing,Epithelium,Cell adhesion,Cell adhesion molecule,Chemokine receptor,Alpha E},
  language     = {eng},
  number       = {5},
  pages        = {563--568},
  publisher    = {Elsevier},
  series       = {Current Opinion in Cell Biology},
  title        = {T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines},
  url          = {http://dx.doi.org/10.1016/S0955-0674(00)00132-0},
  volume       = {12},
  year         = {2000},
}