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T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines

Agace, William LU ; Higgins, J M ; Sadasivan, B ; Brenner, M B and Parker, C M (2000) In Current Opinion in Cell Biology 12(5). p.563-568
Abstract
The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin-... (More)
The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T cell, CD103, Lymphocyte, Chemokine, Homing, Epithelium, Cell adhesion, Cell adhesion molecule, Chemokine receptor, Alpha E
in
Current Opinion in Cell Biology
volume
12
issue
5
pages
563 - 568
publisher
Elsevier
external identifiers
  • pmid:10978890
  • scopus:0033822237
ISSN
0955-0674
DOI
10.1016/S0955-0674(00)00132-0
language
English
LU publication?
yes
id
f60f8fd2-fdd6-404b-9618-a811ef4f7cf3 (old id 1116326)
date added to LUP
2016-04-01 16:51:30
date last changed
2022-01-28 22:39:27
@article{f60f8fd2-fdd6-404b-9618-a811ef4f7cf3,
  abstract     = {{The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites.}},
  author       = {{Agace, William and Higgins, J M and Sadasivan, B and Brenner, M B and Parker, C M}},
  issn         = {{0955-0674}},
  keywords     = {{T cell; CD103; Lymphocyte; Chemokine; Homing; Epithelium; Cell adhesion; Cell adhesion molecule; Chemokine receptor; Alpha E}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{563--568}},
  publisher    = {{Elsevier}},
  series       = {{Current Opinion in Cell Biology}},
  title        = {{T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines}},
  url          = {{http://dx.doi.org/10.1016/S0955-0674(00)00132-0}},
  doi          = {{10.1016/S0955-0674(00)00132-0}},
  volume       = {{12}},
  year         = {{2000}},
}