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Attenuation correction in quantitative SPECT of cerebral blood flow: a Monte Carlo study

Arlig, A; Gustafsson, A; Jacobsson, L; Ljungberg, Michael LU and Wikkelso, C (2000) In Physics in Medicine and Biology 45(12). p.3847-3859
Abstract
Monte Carlo simulation has been used to produce projections from a voxel-based brain phantom, simulating a 99mTc-HMPAO single photon emission computed tomography (SPECT) brain investigation. For comparison, projections free from the effects of attenuation and scattering were also simulated, giving ideal transaxial images after reconstruction. Three methods of attenuation correction were studied: (a) a pre-processing method, (b) a post-processing uniform method and (c) a post-processing non-uniform method using a density map. The accuracy of these methods was estimated by comparison of the reconstructed images with the ideal images using the normalized mean square error, NMSE, and quantitative values of the regional cerebral blood flow,... (More)
Monte Carlo simulation has been used to produce projections from a voxel-based brain phantom, simulating a 99mTc-HMPAO single photon emission computed tomography (SPECT) brain investigation. For comparison, projections free from the effects of attenuation and scattering were also simulated, giving ideal transaxial images after reconstruction. Three methods of attenuation correction were studied: (a) a pre-processing method, (b) a post-processing uniform method and (c) a post-processing non-uniform method using a density map. The accuracy of these methods was estimated by comparison of the reconstructed images with the ideal images using the normalized mean square error, NMSE, and quantitative values of the regional cerebral blood flow, rCBF. A minimum NMSE was achieved for the effective linear attenuation coefficient mu(eff) = 0.07 (0.09) cm(-1) for the uniform(pre) method, the effective mass attenuation coefficient mu(eff)/rho = 0.08 (0.10) cm2 g(-1) for the uniform(post) method and mu(eff)/rho = 0.12 (0.13) cm2 g(-1) for the non-uniform(post) method. Values in parentheses represent the case of dual-window scatter correction. The non-uniform(post) method performed better, as measured by the NMSE, both with and without scatter correction. Furthermore, the non-uniform(post) method gave, on average, more accurate rCBF values. Although the difference in rCBF accuracy was small between the various methods, the same method should be used for patient studies as for the reference material. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
45
issue
12
pages
3847 - 3859
publisher
IOP Publishing
external identifiers
  • pmid:11131204
  • scopus:0034531753
ISSN
1361-6560
DOI
10.1088/0031-9155/45/12/324
language
English
LU publication?
yes
id
8ee337ac-5443-4dcd-ae9e-f6a41f39bd36 (old id 1116463)
date added to LUP
2008-07-01 13:26:54
date last changed
2017-04-09 03:35:31
@article{8ee337ac-5443-4dcd-ae9e-f6a41f39bd36,
  abstract     = {Monte Carlo simulation has been used to produce projections from a voxel-based brain phantom, simulating a 99mTc-HMPAO single photon emission computed tomography (SPECT) brain investigation. For comparison, projections free from the effects of attenuation and scattering were also simulated, giving ideal transaxial images after reconstruction. Three methods of attenuation correction were studied: (a) a pre-processing method, (b) a post-processing uniform method and (c) a post-processing non-uniform method using a density map. The accuracy of these methods was estimated by comparison of the reconstructed images with the ideal images using the normalized mean square error, NMSE, and quantitative values of the regional cerebral blood flow, rCBF. A minimum NMSE was achieved for the effective linear attenuation coefficient mu(eff) = 0.07 (0.09) cm(-1) for the uniform(pre) method, the effective mass attenuation coefficient mu(eff)/rho = 0.08 (0.10) cm2 g(-1) for the uniform(post) method and mu(eff)/rho = 0.12 (0.13) cm2 g(-1) for the non-uniform(post) method. Values in parentheses represent the case of dual-window scatter correction. The non-uniform(post) method performed better, as measured by the NMSE, both with and without scatter correction. Furthermore, the non-uniform(post) method gave, on average, more accurate rCBF values. Although the difference in rCBF accuracy was small between the various methods, the same method should be used for patient studies as for the reference material.},
  author       = {Arlig, A and Gustafsson, A and Jacobsson, L and Ljungberg, Michael and Wikkelso, C},
  issn         = {1361-6560},
  language     = {eng},
  number       = {12},
  pages        = {3847--3859},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Attenuation correction in quantitative SPECT of cerebral blood flow: a Monte Carlo study},
  url          = {http://dx.doi.org/10.1088/0031-9155/45/12/324},
  volume       = {45},
  year         = {2000},
}