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Assessment of liver disease and biochemical and immunological markers in Swedish blood donors with isolated GB virus C/hepatitis G virus viremia

Björkman, Per LU orcid ; Sundström, Gunnar LU ; Veress, Bela LU and Widell, Anders LU (2000) In Vox Sanguinis 78(3). p.143-148
Abstract
OBJECTIVE: To investigate signs of liver disease, and biochemical and immunological markers in blood donors with isolated GBV-C/HGV viremia. METHODS: Eighteen donors with isolated GBV-C/HGV viremia were followed up 3-5 years after initial identification. Testing for GBV-C/HGV RNA, GBV-C/HGV-E2 antibodies and a range of biochemical and immunological tests was performed. Thirteen donors consented to liver biopsy. RESULTS: Twelve donors remained GBV-C/HGV viremic at follow-up. Five donors had developed E2 antibodies. Liver biopsies revealed mild portal inflammatory lesions in 6/11 individuals with persistent viremia, and steatosis in 10/13 biopsied donors. CONCLUSION: Steatosis and mild portal inflammatory lesions were found in liver biopsies... (More)
OBJECTIVE: To investigate signs of liver disease, and biochemical and immunological markers in blood donors with isolated GBV-C/HGV viremia. METHODS: Eighteen donors with isolated GBV-C/HGV viremia were followed up 3-5 years after initial identification. Testing for GBV-C/HGV RNA, GBV-C/HGV-E2 antibodies and a range of biochemical and immunological tests was performed. Thirteen donors consented to liver biopsy. RESULTS: Twelve donors remained GBV-C/HGV viremic at follow-up. Five donors had developed E2 antibodies. Liver biopsies revealed mild portal inflammatory lesions in 6/11 individuals with persistent viremia, and steatosis in 10/13 biopsied donors. CONCLUSION: Steatosis and mild portal inflammatory lesions were found in liver biopsies from several blood donors with isolated GBV-C/HGV viremia. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vox Sanguinis
volume
78
issue
3
pages
143 - 148
publisher
Wiley-Blackwell
external identifiers
  • pmid:10838514
  • scopus:0343729950
ISSN
1423-0410
DOI
10.1159/000031172
language
English
LU publication?
yes
id
c233575c-caea-48dc-b8dc-c6c180c8e8df (old id 1116848)
date added to LUP
2016-04-01 17:00:14
date last changed
2022-01-28 23:39:23
@article{c233575c-caea-48dc-b8dc-c6c180c8e8df,
  abstract     = {{OBJECTIVE: To investigate signs of liver disease, and biochemical and immunological markers in blood donors with isolated GBV-C/HGV viremia. METHODS: Eighteen donors with isolated GBV-C/HGV viremia were followed up 3-5 years after initial identification. Testing for GBV-C/HGV RNA, GBV-C/HGV-E2 antibodies and a range of biochemical and immunological tests was performed. Thirteen donors consented to liver biopsy. RESULTS: Twelve donors remained GBV-C/HGV viremic at follow-up. Five donors had developed E2 antibodies. Liver biopsies revealed mild portal inflammatory lesions in 6/11 individuals with persistent viremia, and steatosis in 10/13 biopsied donors. CONCLUSION: Steatosis and mild portal inflammatory lesions were found in liver biopsies from several blood donors with isolated GBV-C/HGV viremia.}},
  author       = {{Björkman, Per and Sundström, Gunnar and Veress, Bela and Widell, Anders}},
  issn         = {{1423-0410}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{143--148}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Vox Sanguinis}},
  title        = {{Assessment of liver disease and biochemical and immunological markers in Swedish blood donors with isolated GB virus C/hepatitis G virus viremia}},
  url          = {{http://dx.doi.org/10.1159/000031172}},
  doi          = {{10.1159/000031172}},
  volume       = {{78}},
  year         = {{2000}},
}