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Reduced regional cerebral blood flow in non-psychotic violent offenders

Anckarsäter, Henrik LU ; Tullberg, Mats; Wikkelso, Carsten; Ekholm, Sven and Forsman, Anders (2000) In Psychiatry Research 98(1). p.29-41
Abstract
The present study was designed to replicate previously reported findings of abnormal frontal and/or temporal cerebral blood flow in violent offenders and to control for the influence of major mental disorder (MMD), substance abuse, and current medication. HMPAO-SPECT-CBF and MRI scans from pretrial forensic psychiatric investigations of 21 subjects convicted of impulsive violent crimes were retrospectively re-evaluated. In 16/21 subjects, visual assessment of SPECT scans showed some hypoperfusion in the temporal and/or frontal lobes. MRI showed no corresponding structural damage. Quantified regional cerebral blood flow (rCBF) in defined regions of interest was compared between index cases and 11 healthy control subjects. Index subjects had... (More)
The present study was designed to replicate previously reported findings of abnormal frontal and/or temporal cerebral blood flow in violent offenders and to control for the influence of major mental disorder (MMD), substance abuse, and current medication. HMPAO-SPECT-CBF and MRI scans from pretrial forensic psychiatric investigations of 21 subjects convicted of impulsive violent crimes were retrospectively re-evaluated. In 16/21 subjects, visual assessment of SPECT scans showed some hypoperfusion in the temporal and/or frontal lobes. MRI showed no corresponding structural damage. Quantified regional cerebral blood flow (rCBF) in defined regions of interest was compared between index cases and 11 healthy control subjects. Index subjects had significant reductions in the right angular gyrus and the right medial temporal gyrus, bilaterally in the hippocampus, and in the left white frontal matter, but they had significantly increased rCBF in the parietal association cortex bilaterally. The aberrations were as frequent and severe among the subjects without MMD, substance abuse, and current medication (n=7) as in the entire group of index subjects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Major mental disorder, Substance abuse, Forensic psychiatry, MRI, HMPAO-SPECT, rCBF, Impulsive violence
in
Psychiatry Research
volume
98
issue
1
pages
29 - 41
publisher
Elsevier
external identifiers
  • pmid:10708924
  • scopus:0034723764
ISSN
1872-7123
DOI
10.1016/S0925-4927(99)00049-9
language
English
LU publication?
yes
id
75348eef-6a80-4ac9-96e2-203bc2242657 (old id 1116851)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/10708924
http://www.sciencedirect.com/science/article/pii/S0925492799000499
date added to LUP
2013-10-25 15:11:31
date last changed
2017-10-01 03:42:59
@article{75348eef-6a80-4ac9-96e2-203bc2242657,
  abstract     = {The present study was designed to replicate previously reported findings of abnormal frontal and/or temporal cerebral blood flow in violent offenders and to control for the influence of major mental disorder (MMD), substance abuse, and current medication. HMPAO-SPECT-CBF and MRI scans from pretrial forensic psychiatric investigations of 21 subjects convicted of impulsive violent crimes were retrospectively re-evaluated. In 16/21 subjects, visual assessment of SPECT scans showed some hypoperfusion in the temporal and/or frontal lobes. MRI showed no corresponding structural damage. Quantified regional cerebral blood flow (rCBF) in defined regions of interest was compared between index cases and 11 healthy control subjects. Index subjects had significant reductions in the right angular gyrus and the right medial temporal gyrus, bilaterally in the hippocampus, and in the left white frontal matter, but they had significantly increased rCBF in the parietal association cortex bilaterally. The aberrations were as frequent and severe among the subjects without MMD, substance abuse, and current medication (n=7) as in the entire group of index subjects.},
  author       = {Anckarsäter, Henrik and Tullberg, Mats and Wikkelso, Carsten and Ekholm, Sven and Forsman, Anders},
  issn         = {1872-7123},
  keyword      = {Major mental disorder,Substance abuse,Forensic psychiatry,MRI,HMPAO-SPECT,rCBF,Impulsive violence},
  language     = {eng},
  number       = {1},
  pages        = {29--41},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Reduced regional cerebral blood flow in non-psychotic violent offenders},
  url          = {http://dx.doi.org/10.1016/S0925-4927(99)00049-9},
  volume       = {98},
  year         = {2000},
}