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Smoking and myelodysplastic syndromes

Björk, Jonas LU ; Albin, Maria LU ; Mauritzson, Nils LU ; Strömberg, Ulf LU ; Johansson, Bertil LU and Hagmar, Lars (2000) In Epidemiology 11(3). p.285-291
Abstract
The purpose of this case-control study was to investigate tobacco smoking as a risk factor for myelodysplastic syndromes, emphasizing karyotypic aberrations as markers for exposure and risk differentiation with respect to morphology. We obtained smoking history by interview of 330 cytogenetically investigated adult myelodysplastic syndrome cases and 337 controls, matched with respect to sex, year of birth, and county of living. Smoking for at least 1 year at some time 20 years or less before diagnosis was associated with an elevated relative risk (RR) for primary myelodysplastic syndromes (odds ratio (OR) 1.8; 95% confidence interval (CI) = 1.2-2.7). The results indicated a relation with intensity and duration of smoking as well as a... (More)
The purpose of this case-control study was to investigate tobacco smoking as a risk factor for myelodysplastic syndromes, emphasizing karyotypic aberrations as markers for exposure and risk differentiation with respect to morphology. We obtained smoking history by interview of 330 cytogenetically investigated adult myelodysplastic syndrome cases and 337 controls, matched with respect to sex, year of birth, and county of living. Smoking for at least 1 year at some time 20 years or less before diagnosis was associated with an elevated relative risk (RR) for primary myelodysplastic syndromes (odds ratio (OR) 1.8; 95% confidence interval (CI) = 1.2-2.7). The results indicated a relation with intensity and duration of smoking as well as a decrease in risk a few years after cessation of smoking. Smoking was associated with an increased RR for primary myelodysplastic syndromes with chromosome 7 abnormalities (OR 5.0; 95% CI = 1.1-23). Elevated RRs were also seen for refractory anemia (OR 2.5; 95% CI = 1.2-5.6) and for refractory anemia with ringed sideroblasts (OR 3.2; 95% CI = 0.88-12). The findings suggest that smoking is a risk factor for myelodysplastic syndromes. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
myelodysplastic syndromes, chronic myelomonocytic leukemia, smoking, karyotype, chromosomal aberrations, morphology, case-control study
in
Epidemiology
volume
11
issue
3
pages
285 - 291
publisher
Wolters Kluwer
external identifiers
  • pmid:10784245
  • scopus:0343674722
ISSN
1531-5487
language
English
LU publication?
yes
id
09c011ba-bbbb-451a-a411-dcd0eceacd97 (old id 1117214)
date added to LUP
2016-04-01 11:39:55
date last changed
2022-04-05 03:08:23
@article{09c011ba-bbbb-451a-a411-dcd0eceacd97,
  abstract     = {{The purpose of this case-control study was to investigate tobacco smoking as a risk factor for myelodysplastic syndromes, emphasizing karyotypic aberrations as markers for exposure and risk differentiation with respect to morphology. We obtained smoking history by interview of 330 cytogenetically investigated adult myelodysplastic syndrome cases and 337 controls, matched with respect to sex, year of birth, and county of living. Smoking for at least 1 year at some time 20 years or less before diagnosis was associated with an elevated relative risk (RR) for primary myelodysplastic syndromes (odds ratio (OR) 1.8; 95% confidence interval (CI) = 1.2-2.7). The results indicated a relation with intensity and duration of smoking as well as a decrease in risk a few years after cessation of smoking. Smoking was associated with an increased RR for primary myelodysplastic syndromes with chromosome 7 abnormalities (OR 5.0; 95% CI = 1.1-23). Elevated RRs were also seen for refractory anemia (OR 2.5; 95% CI = 1.2-5.6) and for refractory anemia with ringed sideroblasts (OR 3.2; 95% CI = 0.88-12). The findings suggest that smoking is a risk factor for myelodysplastic syndromes.}},
  author       = {{Björk, Jonas and Albin, Maria and Mauritzson, Nils and Strömberg, Ulf and Johansson, Bertil and Hagmar, Lars}},
  issn         = {{1531-5487}},
  keywords     = {{myelodysplastic syndromes; chronic myelomonocytic leukemia; smoking; karyotype; chromosomal aberrations; morphology; case-control study}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{285--291}},
  publisher    = {{Wolters Kluwer}},
  series       = {{Epidemiology}},
  title        = {{Smoking and myelodysplastic syndromes}},
  volume       = {{11}},
  year         = {{2000}},
}