Load-bearing increases new bone formation in impacted and morselized allografts
(2000) In Clinical Orthopaedics and Related Research p.274-281- Abstract
- The effects of mechanical loading on the incorporation of morselized impacted grafts were addressed in this study. Twelve skeletally mature rabbits were surgically treated. Six rabbits received a proximal tibial joint replacement with a tibial tray and a load-bearing 25-mm long stem. The tibia was packed with fresh frozen, morselized, cancellous rabbit bone. No cement was used. In six other rabbits only the stem was inserted, without a tibial tray, leaving the stem and the likewise impacted bone graft mechanically unloaded. The rabbits were euthanized after 6 weeks, and the tibias were sectioned and analyzed by histomorphometric examination. In the loaded specimens the graft was resorbed and replaced by new bone (30% of area of interest)... (More)
- The effects of mechanical loading on the incorporation of morselized impacted grafts were addressed in this study. Twelve skeletally mature rabbits were surgically treated. Six rabbits received a proximal tibial joint replacement with a tibial tray and a load-bearing 25-mm long stem. The tibia was packed with fresh frozen, morselized, cancellous rabbit bone. No cement was used. In six other rabbits only the stem was inserted, without a tibial tray, leaving the stem and the likewise impacted bone graft mechanically unloaded. The rabbits were euthanized after 6 weeks, and the tibias were sectioned and analyzed by histomorphometric examination. In the loaded specimens the graft was resorbed and replaced by new bone (30% of area of interest) to a larger extent than in the unloaded specimens. Mechanical loading of an impacted, morselized graft surrounding a conical uncemented stem, increased the amount of new bone that replaced the graft. The ability of morselized impacted grafts to allow mechanical stimulation of ingrown tissue appears to be a principal cause for the success of this grafting procedure. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1117286
- author
- Wang, Jian-Sheng LU ; Tägil, Magnus LU and Aspenberg, Per LU
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Orthopaedics and Related Research
- issue
- 378
- pages
- 274 - 281
- publisher
- Wolters Kluwer Health Inc
- external identifiers
-
- pmid:10987003
- scopus:0033857165
- ISSN
- 0009-921X
- language
- English
- LU publication?
- yes
- id
- cfcc8221-1d0e-4dfd-823b-c451dde4a9c3 (old id 1117286)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/10987003
- date added to LUP
- 2016-04-01 12:33:25
- date last changed
- 2025-01-02 22:16:09
@article{cfcc8221-1d0e-4dfd-823b-c451dde4a9c3,
abstract = {{The effects of mechanical loading on the incorporation of morselized impacted grafts were addressed in this study. Twelve skeletally mature rabbits were surgically treated. Six rabbits received a proximal tibial joint replacement with a tibial tray and a load-bearing 25-mm long stem. The tibia was packed with fresh frozen, morselized, cancellous rabbit bone. No cement was used. In six other rabbits only the stem was inserted, without a tibial tray, leaving the stem and the likewise impacted bone graft mechanically unloaded. The rabbits were euthanized after 6 weeks, and the tibias were sectioned and analyzed by histomorphometric examination. In the loaded specimens the graft was resorbed and replaced by new bone (30% of area of interest) to a larger extent than in the unloaded specimens. Mechanical loading of an impacted, morselized graft surrounding a conical uncemented stem, increased the amount of new bone that replaced the graft. The ability of morselized impacted grafts to allow mechanical stimulation of ingrown tissue appears to be a principal cause for the success of this grafting procedure.}},
author = {{Wang, Jian-Sheng and Tägil, Magnus and Aspenberg, Per}},
issn = {{0009-921X}},
language = {{eng}},
number = {{378}},
pages = {{274--281}},
publisher = {{Wolters Kluwer Health Inc}},
series = {{Clinical Orthopaedics and Related Research}},
title = {{Load-bearing increases new bone formation in impacted and morselized allografts}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/10987003}},
year = {{2000}},
}