Advanced

Load-bearing increases new bone formation in impacted and morselized allografts

Wang, Jian-Sheng LU ; Tägil, Magnus LU and Aspenberg, Per LU (2000) In Clinical Orthopaedics and Related Research p.274-281
Abstract
The effects of mechanical loading on the incorporation of morselized impacted grafts were addressed in this study. Twelve skeletally mature rabbits were surgically treated. Six rabbits received a proximal tibial joint replacement with a tibial tray and a load-bearing 25-mm long stem. The tibia was packed with fresh frozen, morselized, cancellous rabbit bone. No cement was used. In six other rabbits only the stem was inserted, without a tibial tray, leaving the stem and the likewise impacted bone graft mechanically unloaded. The rabbits were euthanized after 6 weeks, and the tibias were sectioned and analyzed by histomorphometric examination. In the loaded specimens the graft was resorbed and replaced by new bone (30% of area of interest)... (More)
The effects of mechanical loading on the incorporation of morselized impacted grafts were addressed in this study. Twelve skeletally mature rabbits were surgically treated. Six rabbits received a proximal tibial joint replacement with a tibial tray and a load-bearing 25-mm long stem. The tibia was packed with fresh frozen, morselized, cancellous rabbit bone. No cement was used. In six other rabbits only the stem was inserted, without a tibial tray, leaving the stem and the likewise impacted bone graft mechanically unloaded. The rabbits were euthanized after 6 weeks, and the tibias were sectioned and analyzed by histomorphometric examination. In the loaded specimens the graft was resorbed and replaced by new bone (30% of area of interest) to a larger extent than in the unloaded specimens. Mechanical loading of an impacted, morselized graft surrounding a conical uncemented stem, increased the amount of new bone that replaced the graft. The ability of morselized impacted grafts to allow mechanical stimulation of ingrown tissue appears to be a principal cause for the success of this grafting procedure. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Orthopaedics and Related Research
issue
378
pages
274 - 281
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:10987003
  • scopus:0033857165
ISSN
0009-921X
language
English
LU publication?
yes
id
cfcc8221-1d0e-4dfd-823b-c451dde4a9c3 (old id 1117286)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/10987003
date added to LUP
2008-07-01 08:42:48
date last changed
2017-01-01 05:14:57
@article{cfcc8221-1d0e-4dfd-823b-c451dde4a9c3,
  abstract     = {The effects of mechanical loading on the incorporation of morselized impacted grafts were addressed in this study. Twelve skeletally mature rabbits were surgically treated. Six rabbits received a proximal tibial joint replacement with a tibial tray and a load-bearing 25-mm long stem. The tibia was packed with fresh frozen, morselized, cancellous rabbit bone. No cement was used. In six other rabbits only the stem was inserted, without a tibial tray, leaving the stem and the likewise impacted bone graft mechanically unloaded. The rabbits were euthanized after 6 weeks, and the tibias were sectioned and analyzed by histomorphometric examination. In the loaded specimens the graft was resorbed and replaced by new bone (30% of area of interest) to a larger extent than in the unloaded specimens. Mechanical loading of an impacted, morselized graft surrounding a conical uncemented stem, increased the amount of new bone that replaced the graft. The ability of morselized impacted grafts to allow mechanical stimulation of ingrown tissue appears to be a principal cause for the success of this grafting procedure.},
  author       = {Wang, Jian-Sheng and Tägil, Magnus and Aspenberg, Per},
  issn         = {0009-921X},
  language     = {eng},
  number       = {378},
  pages        = {274--281},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Clinical Orthopaedics and Related Research},
  title        = {Load-bearing increases new bone formation in impacted and morselized allografts},
  year         = {2000},
}