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Downregulation of adenosine and P2X receptor-mediated cardiovascular responses in heart failure rats

Zhao, X H ; Sun, X Y ; Erlinge, David LU orcid ; Edvinsson, Lars LU and Hedner, T (2000) In Blood Pressure 9. p.152-1610
Abstract
Neurohormonal changes in congestive heart failure (CHF) include an enhanced peripheral sympathetic nerve activity which results in increased release of noradrenaline, neuropeptide Y and ATP. To examine if such changes in CHF would modulate peripheral pre- and postsynaptic receptors of ATP and its degradation product adenosine, experiments were performed in a rat model of ischaemic CHF. In this model, ischaemia was induced in rats by ligation of the left coronary artery. Our results demonstrate that there is a selective downregulation of P2X receptor-mediated pressor effects, while the hypotensive effects mediated by the endothelial P2Y receptors are unaffected in CHF. Moreover, the adenosine-mediated inhibitory effects on heart rate and... (More)
Neurohormonal changes in congestive heart failure (CHF) include an enhanced peripheral sympathetic nerve activity which results in increased release of noradrenaline, neuropeptide Y and ATP. To examine if such changes in CHF would modulate peripheral pre- and postsynaptic receptors of ATP and its degradation product adenosine, experiments were performed in a rat model of ischaemic CHF. In this model, ischaemia was induced in rats by ligation of the left coronary artery. Our results demonstrate that there is a selective downregulation of P2X receptor-mediated pressor effects, while the hypotensive effects mediated by the endothelial P2Y receptors are unaffected in CHF. Moreover, the adenosine-mediated inhibitory effects on heart rate and blood pressure were also attenuated in the CHF rats. The most important changes in adenosine and P2-receptor function induced by ischaemic CHF were the reduced pressor effect mediated by the P2X receptor and the increased heart rate due to an attenuated inhibitory effect of adenosine. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Pressure
volume
9
pages
152 - 1610
publisher
Taylor & Francis
external identifiers
  • pmid:10855740
  • scopus:0034078283
ISSN
0803-7051
DOI
10.1080/080370500453500
language
English
LU publication?
yes
id
19f32e52-f23f-48ec-9775-f8a71bb87107 (old id 1117317)
date added to LUP
2016-04-01 12:15:15
date last changed
2024-10-09 03:11:07
@article{19f32e52-f23f-48ec-9775-f8a71bb87107,
  abstract     = {{Neurohormonal changes in congestive heart failure (CHF) include an enhanced peripheral sympathetic nerve activity which results in increased release of noradrenaline, neuropeptide Y and ATP. To examine if such changes in CHF would modulate peripheral pre- and postsynaptic receptors of ATP and its degradation product adenosine, experiments were performed in a rat model of ischaemic CHF. In this model, ischaemia was induced in rats by ligation of the left coronary artery. Our results demonstrate that there is a selective downregulation of P2X receptor-mediated pressor effects, while the hypotensive effects mediated by the endothelial P2Y receptors are unaffected in CHF. Moreover, the adenosine-mediated inhibitory effects on heart rate and blood pressure were also attenuated in the CHF rats. The most important changes in adenosine and P2-receptor function induced by ischaemic CHF were the reduced pressor effect mediated by the P2X receptor and the increased heart rate due to an attenuated inhibitory effect of adenosine.}},
  author       = {{Zhao, X H and Sun, X Y and Erlinge, David and Edvinsson, Lars and Hedner, T}},
  issn         = {{0803-7051}},
  language     = {{eng}},
  pages        = {{152--1610}},
  publisher    = {{Taylor & Francis}},
  series       = {{Blood Pressure}},
  title        = {{Downregulation of adenosine and P2X receptor-mediated cardiovascular responses in heart failure rats}},
  url          = {{http://dx.doi.org/10.1080/080370500453500}},
  doi          = {{10.1080/080370500453500}},
  volume       = {{9}},
  year         = {{2000}},
}