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Downregulation of adenosine and P2X receptor-mediated cardiovascular responses in heart failure rats

Zhao, X H; Sun, X Y; Erlinge, David LU ; Edvinsson, Lars LU and Hedner, T (2000) In Blood Pressure 9. p.152-1610
Abstract
Neurohormonal changes in congestive heart failure (CHF) include an enhanced peripheral sympathetic nerve activity which results in increased release of noradrenaline, neuropeptide Y and ATP. To examine if such changes in CHF would modulate peripheral pre- and postsynaptic receptors of ATP and its degradation product adenosine, experiments were performed in a rat model of ischaemic CHF. In this model, ischaemia was induced in rats by ligation of the left coronary artery. Our results demonstrate that there is a selective downregulation of P2X receptor-mediated pressor effects, while the hypotensive effects mediated by the endothelial P2Y receptors are unaffected in CHF. Moreover, the adenosine-mediated inhibitory effects on heart rate and... (More)
Neurohormonal changes in congestive heart failure (CHF) include an enhanced peripheral sympathetic nerve activity which results in increased release of noradrenaline, neuropeptide Y and ATP. To examine if such changes in CHF would modulate peripheral pre- and postsynaptic receptors of ATP and its degradation product adenosine, experiments were performed in a rat model of ischaemic CHF. In this model, ischaemia was induced in rats by ligation of the left coronary artery. Our results demonstrate that there is a selective downregulation of P2X receptor-mediated pressor effects, while the hypotensive effects mediated by the endothelial P2Y receptors are unaffected in CHF. Moreover, the adenosine-mediated inhibitory effects on heart rate and blood pressure were also attenuated in the CHF rats. The most important changes in adenosine and P2-receptor function induced by ischaemic CHF were the reduced pressor effect mediated by the P2X receptor and the increased heart rate due to an attenuated inhibitory effect of adenosine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Pressure
volume
9
pages
152 - 1610
publisher
Taylor & Francis
external identifiers
  • pmid:10855740
  • scopus:0034078283
ISSN
0803-7051
DOI
10.1080/080370500453500
language
English
LU publication?
yes
id
19f32e52-f23f-48ec-9775-f8a71bb87107 (old id 1117317)
date added to LUP
2008-07-03 11:06:05
date last changed
2017-01-01 04:58:47
@article{19f32e52-f23f-48ec-9775-f8a71bb87107,
  abstract     = {Neurohormonal changes in congestive heart failure (CHF) include an enhanced peripheral sympathetic nerve activity which results in increased release of noradrenaline, neuropeptide Y and ATP. To examine if such changes in CHF would modulate peripheral pre- and postsynaptic receptors of ATP and its degradation product adenosine, experiments were performed in a rat model of ischaemic CHF. In this model, ischaemia was induced in rats by ligation of the left coronary artery. Our results demonstrate that there is a selective downregulation of P2X receptor-mediated pressor effects, while the hypotensive effects mediated by the endothelial P2Y receptors are unaffected in CHF. Moreover, the adenosine-mediated inhibitory effects on heart rate and blood pressure were also attenuated in the CHF rats. The most important changes in adenosine and P2-receptor function induced by ischaemic CHF were the reduced pressor effect mediated by the P2X receptor and the increased heart rate due to an attenuated inhibitory effect of adenosine.},
  author       = {Zhao, X H and Sun, X Y and Erlinge, David and Edvinsson, Lars and Hedner, T},
  issn         = {0803-7051},
  language     = {eng},
  pages        = {152--1610},
  publisher    = {Taylor & Francis},
  series       = {Blood Pressure},
  title        = {Downregulation of adenosine and P2X receptor-mediated cardiovascular responses in heart failure rats},
  url          = {http://dx.doi.org/10.1080/080370500453500},
  volume       = {9},
  year         = {2000},
}