Forearm blood flow responses to neuropeptide Y, noradrenaline and adenosine 5'-triphosphate in hypertensive and normotensive subjects
(2000) In Blood Pressure 9. p.126-131- Abstract
- Neuropeptide Y (NPY), noradrenaline (NA) and adenosine 5'-triphosphate (ATP) are important co-transmitters in the sympathetic nervous system, which has a central role in cardiovascular control. In order to evaluate if hypertension is associated with alterations in vascular responses to sympathetic co-transmitters we studied the effects of intra-arterial infusion of NPY, NA and ATP on forearm blood flow. Blood flow was measured by venous occlusion plethysmography in six hypertensive (mean arterial blood pressure (MAP) 113 +/- 4 mmHg) and six matched normotensive subjects (MAP 97 +/- 3 mmHg). NPY and NA significantly reduced forearm blood flow, while a powerful increase was seen with ATP. Forearm vascular resistance, calculated as MAP... (More)
- Neuropeptide Y (NPY), noradrenaline (NA) and adenosine 5'-triphosphate (ATP) are important co-transmitters in the sympathetic nervous system, which has a central role in cardiovascular control. In order to evaluate if hypertension is associated with alterations in vascular responses to sympathetic co-transmitters we studied the effects of intra-arterial infusion of NPY, NA and ATP on forearm blood flow. Blood flow was measured by venous occlusion plethysmography in six hypertensive (mean arterial blood pressure (MAP) 113 +/- 4 mmHg) and six matched normotensive subjects (MAP 97 +/- 3 mmHg). NPY and NA significantly reduced forearm blood flow, while a powerful increase was seen with ATP. Forearm vascular resistance, calculated as MAP divided by forearm blood flow, was significantly increased by NPY and NA and strongly reduced by ATP. There was no difference between hypertensive and normotensive subjects in response to either transmitter. In conclusion, vascular reactivity to intra-arterial administration of NPY, NA and ATP seems to be intact in hypertensive patients without metabolic aberrations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1117322
- author
- Nilsson, Torun
; Hrafnkelsdottir, Thordis
; Edvinsson, Lars
LU
; Jern, Sverker
; Erlinge, David
LU
and Wall, Ulrika
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- forearm blood flow, adenosine 5'-triphosphate, hypertension, neuropeptide Y, noradrenaline
- in
- Blood Pressure
- volume
- 9
- pages
- 126 - 131
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:10855736
- scopus:0342748565
- ISSN
- 0803-7051
- DOI
- 10.1080/080370500453465
- language
- English
- LU publication?
- yes
- id
- e7c15822-0488-44f3-b6b0-9520514c6090 (old id 1117322)
- date added to LUP
- 2016-04-01 12:20:22
- date last changed
- 2022-01-27 02:12:57
@article{e7c15822-0488-44f3-b6b0-9520514c6090, abstract = {{Neuropeptide Y (NPY), noradrenaline (NA) and adenosine 5'-triphosphate (ATP) are important co-transmitters in the sympathetic nervous system, which has a central role in cardiovascular control. In order to evaluate if hypertension is associated with alterations in vascular responses to sympathetic co-transmitters we studied the effects of intra-arterial infusion of NPY, NA and ATP on forearm blood flow. Blood flow was measured by venous occlusion plethysmography in six hypertensive (mean arterial blood pressure (MAP) 113 +/- 4 mmHg) and six matched normotensive subjects (MAP 97 +/- 3 mmHg). NPY and NA significantly reduced forearm blood flow, while a powerful increase was seen with ATP. Forearm vascular resistance, calculated as MAP divided by forearm blood flow, was significantly increased by NPY and NA and strongly reduced by ATP. There was no difference between hypertensive and normotensive subjects in response to either transmitter. In conclusion, vascular reactivity to intra-arterial administration of NPY, NA and ATP seems to be intact in hypertensive patients without metabolic aberrations.}}, author = {{Nilsson, Torun and Hrafnkelsdottir, Thordis and Edvinsson, Lars and Jern, Sverker and Erlinge, David and Wall, Ulrika}}, issn = {{0803-7051}}, keywords = {{forearm blood flow; adenosine 5'-triphosphate; hypertension; neuropeptide Y; noradrenaline}}, language = {{eng}}, pages = {{126--131}}, publisher = {{Taylor & Francis}}, series = {{Blood Pressure}}, title = {{Forearm blood flow responses to neuropeptide Y, noradrenaline and adenosine 5'-triphosphate in hypertensive and normotensive subjects}}, url = {{http://dx.doi.org/10.1080/080370500453465}}, doi = {{10.1080/080370500453465}}, volume = {{9}}, year = {{2000}}, }