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Forearm blood flow responses to neuropeptide Y, noradrenaline and adenosine 5'-triphosphate in hypertensive and normotensive subjects

Nilsson, Torun; Hrafnkelsdottir, Thordis; Edvinsson, Lars LU ; Jern, Sverker; Erlinge, David LU and Wall, Ulrika (2000) In Blood Pressure 9. p.126-131
Abstract
Neuropeptide Y (NPY), noradrenaline (NA) and adenosine 5'-triphosphate (ATP) are important co-transmitters in the sympathetic nervous system, which has a central role in cardiovascular control. In order to evaluate if hypertension is associated with alterations in vascular responses to sympathetic co-transmitters we studied the effects of intra-arterial infusion of NPY, NA and ATP on forearm blood flow. Blood flow was measured by venous occlusion plethysmography in six hypertensive (mean arterial blood pressure (MAP) 113 +/- 4 mmHg) and six matched normotensive subjects (MAP 97 +/- 3 mmHg). NPY and NA significantly reduced forearm blood flow, while a powerful increase was seen with ATP. Forearm vascular resistance, calculated as MAP... (More)
Neuropeptide Y (NPY), noradrenaline (NA) and adenosine 5'-triphosphate (ATP) are important co-transmitters in the sympathetic nervous system, which has a central role in cardiovascular control. In order to evaluate if hypertension is associated with alterations in vascular responses to sympathetic co-transmitters we studied the effects of intra-arterial infusion of NPY, NA and ATP on forearm blood flow. Blood flow was measured by venous occlusion plethysmography in six hypertensive (mean arterial blood pressure (MAP) 113 +/- 4 mmHg) and six matched normotensive subjects (MAP 97 +/- 3 mmHg). NPY and NA significantly reduced forearm blood flow, while a powerful increase was seen with ATP. Forearm vascular resistance, calculated as MAP divided by forearm blood flow, was significantly increased by NPY and NA and strongly reduced by ATP. There was no difference between hypertensive and normotensive subjects in response to either transmitter. In conclusion, vascular reactivity to intra-arterial administration of NPY, NA and ATP seems to be intact in hypertensive patients without metabolic aberrations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
forearm blood flow, adenosine 5'-triphosphate, hypertension, neuropeptide Y, noradrenaline
in
Blood Pressure
volume
9
pages
126 - 131
publisher
Taylor & Francis
external identifiers
  • pmid:10855736
  • scopus:0342748565
ISSN
0803-7051
DOI
10.1080/080370500453465
language
English
LU publication?
yes
id
e7c15822-0488-44f3-b6b0-9520514c6090 (old id 1117322)
date added to LUP
2008-07-03 11:10:28
date last changed
2017-01-01 05:03:24
@article{e7c15822-0488-44f3-b6b0-9520514c6090,
  abstract     = {Neuropeptide Y (NPY), noradrenaline (NA) and adenosine 5'-triphosphate (ATP) are important co-transmitters in the sympathetic nervous system, which has a central role in cardiovascular control. In order to evaluate if hypertension is associated with alterations in vascular responses to sympathetic co-transmitters we studied the effects of intra-arterial infusion of NPY, NA and ATP on forearm blood flow. Blood flow was measured by venous occlusion plethysmography in six hypertensive (mean arterial blood pressure (MAP) 113 +/- 4 mmHg) and six matched normotensive subjects (MAP 97 +/- 3 mmHg). NPY and NA significantly reduced forearm blood flow, while a powerful increase was seen with ATP. Forearm vascular resistance, calculated as MAP divided by forearm blood flow, was significantly increased by NPY and NA and strongly reduced by ATP. There was no difference between hypertensive and normotensive subjects in response to either transmitter. In conclusion, vascular reactivity to intra-arterial administration of NPY, NA and ATP seems to be intact in hypertensive patients without metabolic aberrations.},
  author       = {Nilsson, Torun and Hrafnkelsdottir, Thordis and Edvinsson, Lars and Jern, Sverker and Erlinge, David and Wall, Ulrika},
  issn         = {0803-7051},
  keyword      = {forearm blood flow,adenosine 5'-triphosphate,hypertension,neuropeptide Y,noradrenaline},
  language     = {eng},
  pages        = {126--131},
  publisher    = {Taylor & Francis},
  series       = {Blood Pressure},
  title        = {Forearm blood flow responses to neuropeptide Y, noradrenaline and adenosine 5'-triphosphate in hypertensive and normotensive subjects},
  url          = {http://dx.doi.org/10.1080/080370500453465},
  volume       = {9},
  year         = {2000},
}