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Increased neurogenesis in a model of electroconvulsive therapy

Madsen, T M; Treschow, Alexandra LU ; Bengzon, Johan LU ; Bolwig, T G; Lindvall, Olle LU and Tingström, Anders LU (2000) In Biological Psychiatry 47(12). p.1043-1049
Abstract
BACKGROUND: Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry, although the basis for its therapeutic effect is still unknown. Past research has shown seizure activity to be a regulator of neurogenesis in the adult brain. This study examines the effect of a single and multiple electroconvulsive seizures on neurogenesis in the rat dentate gyrus. METHODS: Rats were given either a single or a series of 10 electroconvulsive seizures. At different times after the seizures, a marker of proliferating cells, Bromodeoxyuridine (BrdU), was administered to the animals. Subsequently, newborn cells positive for BrdU were counted in the dentate gyrus. Double staining with a neuron-specific marker indicated... (More)
BACKGROUND: Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry, although the basis for its therapeutic effect is still unknown. Past research has shown seizure activity to be a regulator of neurogenesis in the adult brain. This study examines the effect of a single and multiple electroconvulsive seizures on neurogenesis in the rat dentate gyrus. METHODS: Rats were given either a single or a series of 10 electroconvulsive seizures. At different times after the seizures, a marker of proliferating cells, Bromodeoxyuridine (BrdU), was administered to the animals. Subsequently, newborn cells positive for BrdU were counted in the dentate gyrus. Double staining with a neuron-specific marker indicated that the newborn cells displayed a neuronal phenotype. RESULTS: A single electroconvulsive seizure significantly increased the number of new born cells in the dentate gyrus. These cells survived for at least 3 months. A series of seizures further increased neurogenesis, indicating a dose-dependent mechanism. CONCLUSIONS: We propose that generation of new neurons in the hippocampus may be an important neurobiologic element underlying the clinical effects of electroconvulsive seizures. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biological Psychiatry
volume
47
issue
12
pages
1043 - 1049
publisher
Society of Biological Psychiatry Published by Elsevier Inc.
external identifiers
  • pmid:10862803
  • scopus:0034040357
ISSN
0006-3223
DOI
10.1016/S0006-3223(00)00228-6
language
English
LU publication?
yes
id
b7b66705-8b6c-497a-a30b-15b9c13fda38 (old id 1117617)
date added to LUP
2008-06-27 10:42:51
date last changed
2017-08-13 03:37:29
@article{b7b66705-8b6c-497a-a30b-15b9c13fda38,
  abstract     = {BACKGROUND: Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry, although the basis for its therapeutic effect is still unknown. Past research has shown seizure activity to be a regulator of neurogenesis in the adult brain. This study examines the effect of a single and multiple electroconvulsive seizures on neurogenesis in the rat dentate gyrus. METHODS: Rats were given either a single or a series of 10 electroconvulsive seizures. At different times after the seizures, a marker of proliferating cells, Bromodeoxyuridine (BrdU), was administered to the animals. Subsequently, newborn cells positive for BrdU were counted in the dentate gyrus. Double staining with a neuron-specific marker indicated that the newborn cells displayed a neuronal phenotype. RESULTS: A single electroconvulsive seizure significantly increased the number of new born cells in the dentate gyrus. These cells survived for at least 3 months. A series of seizures further increased neurogenesis, indicating a dose-dependent mechanism. CONCLUSIONS: We propose that generation of new neurons in the hippocampus may be an important neurobiologic element underlying the clinical effects of electroconvulsive seizures.},
  author       = {Madsen, T M and Treschow, Alexandra and Bengzon, Johan and Bolwig, T G and Lindvall, Olle and Tingström, Anders},
  issn         = {0006-3223},
  language     = {eng},
  number       = {12},
  pages        = {1043--1049},
  publisher    = {Society of Biological Psychiatry Published by Elsevier Inc.},
  series       = {Biological Psychiatry},
  title        = {Increased neurogenesis in a model of electroconvulsive therapy},
  url          = {http://dx.doi.org/10.1016/S0006-3223(00)00228-6},
  volume       = {47},
  year         = {2000},
}