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The rotating pole test: evaluation of its effectiveness in assessing functional motor deficits following experimental head injury in the rat

Mattiasson, Gustav LU ; Philips, M F; Tomasevic, Gregor LU ; Johansson, Barbro LU ; Wieloch, Tadeusz LU and McIntosh, T K (2000) In Journal of Neuroscience Methods 95(1). p.75-82
Abstract
Neurological motor dysfunction is often an integral component of the neurological sequelae of traumatic brain injury (TBI). In experimental TBI, neurological motor testing is an outcome measure used to monitor severity of injury, and the response to treatment. This study evaluates the effectiveness and sensitivity of the rotating pole test (RP) to characterize and evaluate the temporal course of motor deficits after lateral fluid percussion (FP) injury to the rat brain. The results are compared with the previously characterized and widely used composite neuroscore of motor function (NS). The animals were required to walk across an elevated wooden pole that was either stationary or rotating to left or right directions at different speeds.... (More)
Neurological motor dysfunction is often an integral component of the neurological sequelae of traumatic brain injury (TBI). In experimental TBI, neurological motor testing is an outcome measure used to monitor severity of injury, and the response to treatment. This study evaluates the effectiveness and sensitivity of the rotating pole test (RP) to characterize and evaluate the temporal course of motor deficits after lateral fluid percussion (FP) injury to the rat brain. The results are compared with the previously characterized and widely used composite neuroscore of motor function (NS). The animals were required to walk across an elevated wooden pole that was either stationary or rotating to left or right directions at different speeds. Male Wistar rats underwent lateral FP injury of moderate severity (mean 2.4 atm, n = 9) or sham surgery (n = 9), and were tested at 48 h and 7 days post-injury using the NS and RP. The results of the NS directly correlated to the results of the RP, showing a significant injury effect at both 48 h and 7 days. This is the first study to show that the RP-test detects neurological motor deficits after lateral FP injury, and suggests that this technique is a reliable behavioral tool for evaluating neurological motor function in the acute period after experimental TBI. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroscience Methods
volume
95
issue
1
pages
75 - 82
publisher
Elsevier
external identifiers
  • pmid:10776817
  • scopus:0033957375
ISSN
1872-678X
DOI
10.1016/S0165-0270(99)00162-4
language
English
LU publication?
yes
id
dc751338-cac8-4ded-9845-2954a28d1acc (old id 1117892)
date added to LUP
2008-06-24 14:21:34
date last changed
2017-01-01 04:48:44
@article{dc751338-cac8-4ded-9845-2954a28d1acc,
  abstract     = {Neurological motor dysfunction is often an integral component of the neurological sequelae of traumatic brain injury (TBI). In experimental TBI, neurological motor testing is an outcome measure used to monitor severity of injury, and the response to treatment. This study evaluates the effectiveness and sensitivity of the rotating pole test (RP) to characterize and evaluate the temporal course of motor deficits after lateral fluid percussion (FP) injury to the rat brain. The results are compared with the previously characterized and widely used composite neuroscore of motor function (NS). The animals were required to walk across an elevated wooden pole that was either stationary or rotating to left or right directions at different speeds. Male Wistar rats underwent lateral FP injury of moderate severity (mean 2.4 atm, n = 9) or sham surgery (n = 9), and were tested at 48 h and 7 days post-injury using the NS and RP. The results of the NS directly correlated to the results of the RP, showing a significant injury effect at both 48 h and 7 days. This is the first study to show that the RP-test detects neurological motor deficits after lateral FP injury, and suggests that this technique is a reliable behavioral tool for evaluating neurological motor function in the acute period after experimental TBI.},
  author       = {Mattiasson, Gustav and Philips, M F and Tomasevic, Gregor and Johansson, Barbro and Wieloch, Tadeusz and McIntosh, T K},
  issn         = {1872-678X},
  language     = {eng},
  number       = {1},
  pages        = {75--82},
  publisher    = {Elsevier},
  series       = {Journal of Neuroscience Methods},
  title        = {The rotating pole test: evaluation of its effectiveness in assessing functional motor deficits following experimental head injury in the rat},
  url          = {http://dx.doi.org/10.1016/S0165-0270(99)00162-4},
  volume       = {95},
  year         = {2000},
}