The rotating pole test: evaluation of its effectiveness in assessing functional motor deficits following experimental head injury in the rat
(2000) In Journal of Neuroscience Methods 95(1). p.75-82- Abstract
- Neurological motor dysfunction is often an integral component of the neurological sequelae of traumatic brain injury (TBI). In experimental TBI, neurological motor testing is an outcome measure used to monitor severity of injury, and the response to treatment. This study evaluates the effectiveness and sensitivity of the rotating pole test (RP) to characterize and evaluate the temporal course of motor deficits after lateral fluid percussion (FP) injury to the rat brain. The results are compared with the previously characterized and widely used composite neuroscore of motor function (NS). The animals were required to walk across an elevated wooden pole that was either stationary or rotating to left or right directions at different speeds.... (More)
- Neurological motor dysfunction is often an integral component of the neurological sequelae of traumatic brain injury (TBI). In experimental TBI, neurological motor testing is an outcome measure used to monitor severity of injury, and the response to treatment. This study evaluates the effectiveness and sensitivity of the rotating pole test (RP) to characterize and evaluate the temporal course of motor deficits after lateral fluid percussion (FP) injury to the rat brain. The results are compared with the previously characterized and widely used composite neuroscore of motor function (NS). The animals were required to walk across an elevated wooden pole that was either stationary or rotating to left or right directions at different speeds. Male Wistar rats underwent lateral FP injury of moderate severity (mean 2.4 atm, n = 9) or sham surgery (n = 9), and were tested at 48 h and 7 days post-injury using the NS and RP. The results of the NS directly correlated to the results of the RP, showing a significant injury effect at both 48 h and 7 days. This is the first study to show that the RP-test detects neurological motor deficits after lateral FP injury, and suggests that this technique is a reliable behavioral tool for evaluating neurological motor function in the acute period after experimental TBI. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1117892
- author
- Mattiasson, Gustav LU ; Philips, M F ; Tomasevic, Gregor LU ; Johansson, Barbro LU ; Wieloch, Tadeusz LU and McIntosh, T K
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuroscience Methods
- volume
- 95
- issue
- 1
- pages
- 75 - 82
- publisher
- Elsevier
- external identifiers
-
- pmid:10776817
- scopus:0033957375
- ISSN
- 1872-678X
- DOI
- 10.1016/S0165-0270(99)00162-4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurosurgery (013026000), Experimental Brain Research (0131000120), Neurology, Lund (013027000)
- id
- dc751338-cac8-4ded-9845-2954a28d1acc (old id 1117892)
- date added to LUP
- 2016-04-01 12:04:28
- date last changed
- 2022-01-26 22:24:06
@article{dc751338-cac8-4ded-9845-2954a28d1acc, abstract = {{Neurological motor dysfunction is often an integral component of the neurological sequelae of traumatic brain injury (TBI). In experimental TBI, neurological motor testing is an outcome measure used to monitor severity of injury, and the response to treatment. This study evaluates the effectiveness and sensitivity of the rotating pole test (RP) to characterize and evaluate the temporal course of motor deficits after lateral fluid percussion (FP) injury to the rat brain. The results are compared with the previously characterized and widely used composite neuroscore of motor function (NS). The animals were required to walk across an elevated wooden pole that was either stationary or rotating to left or right directions at different speeds. Male Wistar rats underwent lateral FP injury of moderate severity (mean 2.4 atm, n = 9) or sham surgery (n = 9), and were tested at 48 h and 7 days post-injury using the NS and RP. The results of the NS directly correlated to the results of the RP, showing a significant injury effect at both 48 h and 7 days. This is the first study to show that the RP-test detects neurological motor deficits after lateral FP injury, and suggests that this technique is a reliable behavioral tool for evaluating neurological motor function in the acute period after experimental TBI.}}, author = {{Mattiasson, Gustav and Philips, M F and Tomasevic, Gregor and Johansson, Barbro and Wieloch, Tadeusz and McIntosh, T K}}, issn = {{1872-678X}}, language = {{eng}}, number = {{1}}, pages = {{75--82}}, publisher = {{Elsevier}}, series = {{Journal of Neuroscience Methods}}, title = {{The rotating pole test: evaluation of its effectiveness in assessing functional motor deficits following experimental head injury in the rat}}, url = {{http://dx.doi.org/10.1016/S0165-0270(99)00162-4}}, doi = {{10.1016/S0165-0270(99)00162-4}}, volume = {{95}}, year = {{2000}}, }