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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Horikawa, Y; Oda, N; Cox, N J; Li, X; Orho-Melander, Marju LU ; Hara, M; Hinokio, Y; Lindner, T H; Mashima, H and Schwarz, P E, et al. (2000) In Nature Genetics 26(2). p.163-175
Abstract
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine... (More)
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes. (Less)
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publication status
published
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Nature Genetics
volume
26
issue
2
pages
163 - 175
publisher
Nature Publishing Group
external identifiers
  • pmid:11017071
  • scopus:0033772073
ISSN
1546-1718
DOI
10.1038/79876
language
English
LU publication?
yes
id
ad4d5ab3-7a8c-41d2-86b9-c740b0fa2a81 (old id 1118025)
date added to LUP
2008-06-24 13:50:16
date last changed
2017-11-12 04:01:29
@article{ad4d5ab3-7a8c-41d2-86b9-c740b0fa2a81,
  abstract     = {Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.},
  author       = {Horikawa, Y and Oda, N and Cox, N J and Li, X and Orho-Melander, Marju and Hara, M and Hinokio, Y and Lindner, T H and Mashima, H and Schwarz, P E and del Bosque-Plata, L and Horikawa, Y and Oda, Y and Yoshiuchi, I and Colilla, S and Polonsky, K S and Wei, S and Concannon, P and Iwasaki, N and Schulze, J and Baier, Leslie J. and Bogardus, Clifton and Groop, Leif and Boerwinkle, Eric and Hanis, Craig L. and Bell, Graeme I.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {2},
  pages        = {163--175},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus},
  url          = {http://dx.doi.org/10.1038/79876},
  volume       = {26},
  year         = {2000},
}