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Computed tomography of pulmonary metastases from osteosarcoma: The less poor technique. A study of 51 patients with histological correlation

Picci, P.; Vanel, D.; Briccoli, A.; Talle, K.; Haakenaasen, U.; Malaguti, C.; Monti, C.; Ferrari, C.; Bacci, G. and Saeter, G., et al. (2001) In Annals of Oncology 12(11). p.1601-1604
Abstract
Background: The purpose is to evaluate the accuracy of computed tomography (CT) in the pulmonary staging of osteosarcoma. Patients and methods: Fifty-one patients presenting with osteosarcoma and at initial CT considered metastatic to the chest had lung surgery. Two teams of two senior radiologists independently reviewed all CT examinations. Their results were compared to the histological studies. Results: One hundred nineteen CT's were reviewed. The 2 teams found 247 and 268 nodules on the initial, and 143 and 146 nodules on the preoperative CT. Histological studies confirmed metastatic nodules in 29 patients. Two hundred four nodules were excised and studied. One hundred nine were metastases. The 22 patients without metastases had 53... (More)
Background: The purpose is to evaluate the accuracy of computed tomography (CT) in the pulmonary staging of osteosarcoma. Patients and methods: Fifty-one patients presenting with osteosarcoma and at initial CT considered metastatic to the chest had lung surgery. Two teams of two senior radiologists independently reviewed all CT examinations. Their results were compared to the histological studies. Results: One hundred nineteen CT's were reviewed. The 2 teams found 247 and 268 nodules on the initial, and 143 and 146 nodules on the preoperative CT. Histological studies confirmed metastatic nodules in 29 patients. Two hundred four nodules were excised and studied. One hundred nine were metastases. The 22 patients without metastases had 53 negative nodules removed. In the 29 patients with metastases, 151 nodules were removed, and 42 were non-metastatic. The positive predictive value was 53% with regard to 'nodules', and 57% with regard to 'patients'. Only 4 out of 13 patients with one nodule at surgery were metastatic, but all patients with more than 7 nodules were metastatic. The 46 cases with several available CT's, showed that no change in the number of nodules was more frequent in benign lesions. Other criteria revealed no significant difference. Conclusion: CT positive predictive value is limited, but as surgery is the only way to cure metastatic patients, CT will still be used as the reference technique until a more specific approach can be found. (Less)
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keywords
pulmonary metastases, CT, osteosarcoma
in
Annals of Oncology
volume
12
issue
11
pages
1601 - 1604
publisher
Oxford University Press
external identifiers
  • wos:000172586200022
  • scopus:0035690203
ISSN
1569-8041
language
English
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yes
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5c6555f7-6eb2-48fe-8e9b-24aed7bc9cbf (old id 1118623)
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http://annonc.oxfordjournals.org/content/12/11/1601.abstract
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2008-07-10 09:53:41
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2018-03-18 04:34:00
@article{5c6555f7-6eb2-48fe-8e9b-24aed7bc9cbf,
  abstract     = {Background: The purpose is to evaluate the accuracy of computed tomography (CT) in the pulmonary staging of osteosarcoma. Patients and methods: Fifty-one patients presenting with osteosarcoma and at initial CT considered metastatic to the chest had lung surgery. Two teams of two senior radiologists independently reviewed all CT examinations. Their results were compared to the histological studies. Results: One hundred nineteen CT's were reviewed. The 2 teams found 247 and 268 nodules on the initial, and 143 and 146 nodules on the preoperative CT. Histological studies confirmed metastatic nodules in 29 patients. Two hundred four nodules were excised and studied. One hundred nine were metastases. The 22 patients without metastases had 53 negative nodules removed. In the 29 patients with metastases, 151 nodules were removed, and 42 were non-metastatic. The positive predictive value was 53% with regard to 'nodules', and 57% with regard to 'patients'. Only 4 out of 13 patients with one nodule at surgery were metastatic, but all patients with more than 7 nodules were metastatic. The 46 cases with several available CT's, showed that no change in the number of nodules was more frequent in benign lesions. Other criteria revealed no significant difference. Conclusion: CT positive predictive value is limited, but as surgery is the only way to cure metastatic patients, CT will still be used as the reference technique until a more specific approach can be found.},
  author       = {Picci, P. and Vanel, D. and Briccoli, A. and Talle, K. and Haakenaasen, U. and Malaguti, C. and Monti, C. and Ferrari, C. and Bacci, G. and Saeter, G. and Alvegård, Thor},
  issn         = {1569-8041},
  keyword      = {pulmonary metastases,CT,osteosarcoma},
  language     = {eng},
  number       = {11},
  pages        = {1601--1604},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Computed tomography of pulmonary metastases from osteosarcoma: The less poor technique. A study of 51 patients with histological correlation},
  volume       = {12},
  year         = {2001},
}