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Neurocan is dispensable for brain development

Zhou, Xiao-Hong; Brakebusch, Cord LU ; Matthies, Henry; Oohashi, Toshitaka; Hirsch, Emilio; Moser, Markus; Krug, Manfred; Seidenbecher, Constanze I.; Boeckers, Tobias M. and Rauch, Uwe LU , et al. (2001) In Molecular and Cellular Biology 21(17). p.5970-5978
Abstract
Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is... (More)
Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is reduced. These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain. (Less)
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Contribution to journal
publication status
published
subject
in
Molecular and Cellular Biology
volume
21
issue
17
pages
5970 - 5978
publisher
American Society for Microbiology
external identifiers
  • wos:000170349900026
  • scopus:0034909716
ISSN
0270-7306
DOI
10.1128/MCB.21.17.5970-5978.2001
language
English
LU publication?
yes
id
ed6cd56b-9371-4710-8068-c304e039ca15 (old id 1119003)
date added to LUP
2008-07-18 16:40:02
date last changed
2018-07-01 03:33:05
@article{ed6cd56b-9371-4710-8068-c304e039ca15,
  abstract     = {Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is reduced. These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain.},
  author       = {Zhou, Xiao-Hong and Brakebusch, Cord and Matthies, Henry and Oohashi, Toshitaka and Hirsch, Emilio and Moser, Markus and Krug, Manfred and Seidenbecher, Constanze I. and Boeckers, Tobias M. and Rauch, Uwe and Buettner, Reinhard and Gundelfinger, Eckart D. and Fässler, Reinhard},
  issn         = {0270-7306},
  language     = {eng},
  number       = {17},
  pages        = {5970--5978},
  publisher    = {American Society for Microbiology},
  series       = {Molecular and Cellular Biology},
  title        = {Neurocan is dispensable for brain development},
  url          = {http://dx.doi.org/10.1128/MCB.21.17.5970-5978.2001},
  volume       = {21},
  year         = {2001},
}