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Effects of hyperbaric oxygen treatment on axonal outgrowth in sciatic nerve grafts in rats

Haapaniemi, Tomas; Nishiura, Yasumasa and Dahlin, Lars LU (2001) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00 35(1). p.41466-41466
Abstract
We studied the effect of hyperbaric oxygen treatment on axonal outgrowth in grafts of sciatic nerves in 40 rats. The sciatic nerve was transsected and a 10 mm long segment from the opposite side was immediately sutured in as a nerve graft. Postoperatively 17 animals were treated with 100% oxygen at 3.2 atmospheres absolute pressure for 45 minutes and the treatment was repeated at four and eight hours postoperatively and then every eight hours until evaluation. At seven days the axonal outgrowth was evaluated by immunohistochemical staining of neurofilaments in the nerve grafts. The axonal outgrowth was significantly longer in animals treated with hyperbaric oxygen. We conclude that hyperbaric oxygen can improve nerve regeneration in... (More)
We studied the effect of hyperbaric oxygen treatment on axonal outgrowth in grafts of sciatic nerves in 40 rats. The sciatic nerve was transsected and a 10 mm long segment from the opposite side was immediately sutured in as a nerve graft. Postoperatively 17 animals were treated with 100% oxygen at 3.2 atmospheres absolute pressure for 45 minutes and the treatment was repeated at four and eight hours postoperatively and then every eight hours until evaluation. At seven days the axonal outgrowth was evaluated by immunohistochemical staining of neurofilaments in the nerve grafts. The axonal outgrowth was significantly longer in animals treated with hyperbaric oxygen. We conclude that hyperbaric oxygen can improve nerve regeneration in sciatic nerve grafts in rats. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Nerve, Regeneration, Hyperbaric, Oxygenation, Graft, Neurofilaments, Rat, Sciatic
in
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00
volume
35
issue
1
pages
41466 - 41466
publisher
Taylor & Francis
external identifiers
  • wos:000167601000002
  • scopus:0035103462
ISSN
1651-2073
DOI
10.1080/02844310151032439
language
English
LU publication?
yes
id
bff2a497-c96d-4c49-9911-f3f60013c92e (old id 1119406)
date added to LUP
2008-06-30 10:38:28
date last changed
2018-01-07 09:28:36
@article{bff2a497-c96d-4c49-9911-f3f60013c92e,
  abstract     = {We studied the effect of hyperbaric oxygen treatment on axonal outgrowth in grafts of sciatic nerves in 40 rats. The sciatic nerve was transsected and a 10 mm long segment from the opposite side was immediately sutured in as a nerve graft. Postoperatively 17 animals were treated with 100% oxygen at 3.2 atmospheres absolute pressure for 45 minutes and the treatment was repeated at four and eight hours postoperatively and then every eight hours until evaluation. At seven days the axonal outgrowth was evaluated by immunohistochemical staining of neurofilaments in the nerve grafts. The axonal outgrowth was significantly longer in animals treated with hyperbaric oxygen. We conclude that hyperbaric oxygen can improve nerve regeneration in sciatic nerve grafts in rats.},
  author       = {Haapaniemi, Tomas and Nishiura, Yasumasa and Dahlin, Lars},
  issn         = {1651-2073},
  keyword      = {Nerve,Regeneration,Hyperbaric,Oxygenation,Graft,Neurofilaments,Rat,Sciatic},
  language     = {eng},
  number       = {1},
  pages        = {41466--41466},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00},
  title        = {Effects of hyperbaric oxygen treatment on axonal outgrowth in sciatic nerve grafts in rats},
  url          = {http://dx.doi.org/10.1080/02844310151032439},
  volume       = {35},
  year         = {2001},
}