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Tissue response to silicone tubes used to repair human median and ulnar nerves

Dahlin, Lars B.; Anagnostaki, Lola and Lundborg, Göran LU (2001) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00 35(1). p.29-34
Abstract
Silicone tubes of appropriate sizes were used to enclose the injured zone of transsected ulnar and median nerves in the human forearm as an alternative to conventional microsurgical repair of the nerve trunk. A gap measuring 3-5 mm was left intentionally between the nerve ends inside the tube. The clinical early results from a prospective randomised study that compared these two principles have recently been presented. Seven patients (five men and two women), aged 15-49 years (median 20) were reexplored 12-44 months (median 22) after the initial procedure because of local discomfort from the tube in four patients. There was a new nerve structure bridging the former gap and in most cases it was impossible to distinguish the site of the... (More)
Silicone tubes of appropriate sizes were used to enclose the injured zone of transsected ulnar and median nerves in the human forearm as an alternative to conventional microsurgical repair of the nerve trunk. A gap measuring 3-5 mm was left intentionally between the nerve ends inside the tube. The clinical early results from a prospective randomised study that compared these two principles have recently been presented. Seven patients (five men and two women), aged 15-49 years (median 20) were reexplored 12-44 months (median 22) after the initial procedure because of local discomfort from the tube in four patients. There was a new nerve structure bridging the former gap and in most cases it was impossible to distinguish the site of the injury. In all cases there was a thin capsule around the silicone tube that microscopically consisted of connective tissue with thin walls and no signs of inflammation granuloma or macrophages (n = 4), while in two cases a mild foreign body reaction was seen at a single site (n = 1) or at patchy areas (n = 1). These results indicate that after more than one year there is a limited tissue reaction around silicone tubes used to repair median and ulnar nerves in humans. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Silicone, Nerve, Repair, Median, Ulnar, Macrophages, Inflammation, Regeneration
in
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00
volume
35
issue
1
pages
29 - 34
publisher
Taylor & Francis
external identifiers
  • wos:000167601000006
  • scopus:0035103085
ISSN
1651-2073
DOI
10.1080/02844310151032510
language
English
LU publication?
yes
id
c4a3bbdf-0a39-4e04-8cc2-29b9df830d9e (old id 1119409)
date added to LUP
2008-06-26 11:17:10
date last changed
2018-01-07 09:12:35
@article{c4a3bbdf-0a39-4e04-8cc2-29b9df830d9e,
  abstract     = {Silicone tubes of appropriate sizes were used to enclose the injured zone of transsected ulnar and median nerves in the human forearm as an alternative to conventional microsurgical repair of the nerve trunk. A gap measuring 3-5 mm was left intentionally between the nerve ends inside the tube. The clinical early results from a prospective randomised study that compared these two principles have recently been presented. Seven patients (five men and two women), aged 15-49 years (median 20) were reexplored 12-44 months (median 22) after the initial procedure because of local discomfort from the tube in four patients. There was a new nerve structure bridging the former gap and in most cases it was impossible to distinguish the site of the injury. In all cases there was a thin capsule around the silicone tube that microscopically consisted of connective tissue with thin walls and no signs of inflammation granuloma or macrophages (n = 4), while in two cases a mild foreign body reaction was seen at a single site (n = 1) or at patchy areas (n = 1). These results indicate that after more than one year there is a limited tissue reaction around silicone tubes used to repair median and ulnar nerves in humans.},
  author       = {Dahlin, Lars B. and Anagnostaki, Lola and Lundborg, Göran},
  issn         = {1651-2073},
  keyword      = {Silicone,Nerve,Repair,Median,Ulnar,Macrophages,Inflammation,Regeneration},
  language     = {eng},
  number       = {1},
  pages        = {29--34},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00},
  title        = {Tissue response to silicone tubes used to repair human median and ulnar nerves},
  url          = {http://dx.doi.org/10.1080/02844310151032510},
  volume       = {35},
  year         = {2001},
}