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Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis

Sakai, Takao LU ; Johnson, Kamin J.; Murozono, Michihiro; Sakai, Keiko LU ; Magnuson, Marc A.; Wieloch, Tadeusz LU ; Cronberg, Tobias LU ; Isshiki, Atsushi; Erickson, Harold P. and Fässler, Reinhard LU (2001) In Nature Medicine 7(3). p.324-330
Abstract
Fibronectin performs essential roles in embryonic development and is prominently expressed during tissue repair. Two forms of fibronectin have been Identified: plasma fibronectin (pFn), which Is expressed by hepatocytes and secreted In soluble form into plasma; and cellular fibronectin (cFn), an insoluble form expressed locally by fibroblasts and other cell types and deposited and assembled into the extracellular matrix. To investigate the role of pFn in vivo, we generated pfn-deficient adult mice using Cre-loxP conditional gene-knockout technology. Here we show that pfn-deficient mice show increased neuronal apoptosis and larger Infarction areas following transient focal cerebral ischemia. However, pFn is dispensable for skin-wound... (More)
Fibronectin performs essential roles in embryonic development and is prominently expressed during tissue repair. Two forms of fibronectin have been Identified: plasma fibronectin (pFn), which Is expressed by hepatocytes and secreted In soluble form into plasma; and cellular fibronectin (cFn), an insoluble form expressed locally by fibroblasts and other cell types and deposited and assembled into the extracellular matrix. To investigate the role of pFn in vivo, we generated pfn-deficient adult mice using Cre-loxP conditional gene-knockout technology. Here we show that pfn-deficient mice show increased neuronal apoptosis and larger Infarction areas following transient focal cerebral ischemia. However, pFn is dispensable for skin-wound healing and hemostasis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Medicine
volume
7
issue
3
pages
324 - 330
publisher
Nature Publishing Group
external identifiers
  • wos:000167380400038
  • scopus:0035099411
ISSN
1546-170X
DOI
10.1038/85471
language
English
LU publication?
yes
id
6ab34973-d933-4e4a-8f99-5f317477e471 (old id 1119495)
date added to LUP
2008-07-14 09:02:52
date last changed
2018-02-04 03:55:28
@article{6ab34973-d933-4e4a-8f99-5f317477e471,
  abstract     = {Fibronectin performs essential roles in embryonic development and is prominently expressed during tissue repair. Two forms of fibronectin have been Identified: plasma fibronectin (pFn), which Is expressed by hepatocytes and secreted In soluble form into plasma; and cellular fibronectin (cFn), an insoluble form expressed locally by fibroblasts and other cell types and deposited and assembled into the extracellular matrix. To investigate the role of pFn in vivo, we generated pfn-deficient adult mice using Cre-loxP conditional gene-knockout technology. Here we show that pfn-deficient mice show increased neuronal apoptosis and larger Infarction areas following transient focal cerebral ischemia. However, pFn is dispensable for skin-wound healing and hemostasis.},
  author       = {Sakai, Takao and Johnson, Kamin J. and Murozono, Michihiro and Sakai, Keiko and Magnuson, Marc A. and Wieloch, Tadeusz and Cronberg, Tobias and Isshiki, Atsushi and Erickson, Harold P. and Fässler, Reinhard},
  issn         = {1546-170X},
  language     = {eng},
  number       = {3},
  pages        = {324--330},
  publisher    = {Nature Publishing Group},
  series       = {Nature Medicine},
  title        = {Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis},
  url          = {http://dx.doi.org/10.1038/85471},
  volume       = {7},
  year         = {2001},
}