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The bone morphogenetic proteins antagonist noggin inhibits membranous ossification

Aspenberg, Per LU ; Jeppsson, Charlotte LU and Economides, Aris N. (2001) In Journal of Bone and Mineral Research 16(3). p.497-500
Abstract
Bone morphogenetic proteins (BMPs) are expressed and secreted during fracture repair. Although they are likely to be required for this process, little is known about their physiological role in bone regeneration. Noggin is a protein that specifically binds and inactivates several BMPs, It plays fundamental roles during early embryonal development and limb morphogenesis by this BMP-inactivating activity. This study shows that Noggin can modify bone formation in vivo in the adult animal and, thus, indirectly, that BMP signaling is indispensable in this process. A noggin mutein (hNg Delta B2-Fc) engineered so as to display increased bioavailability was used. Bilateral titanium bone chambers mere inserted in 70 rats, and side comparisons for... (More)
Bone morphogenetic proteins (BMPs) are expressed and secreted during fracture repair. Although they are likely to be required for this process, little is known about their physiological role in bone regeneration. Noggin is a protein that specifically binds and inactivates several BMPs, It plays fundamental roles during early embryonal development and limb morphogenesis by this BMP-inactivating activity. This study shows that Noggin can modify bone formation in vivo in the adult animal and, thus, indirectly, that BMP signaling is indispensable in this process. A noggin mutein (hNg Delta B2-Fc) engineered so as to display increased bioavailability was used. Bilateral titanium bone chambers mere inserted in 70 rats, and side comparisons for bone formation in the chambers were done. The hNg Delta B2-Fc had no effect on total amount of tissue formed in the chamber but decreased the amount of bone compared with both buffer controls and a control made up of an Fc-tagged IL-6R alpha protein, which had no effects of its own, Also, wild-type noggin inhibited bone formation. Thus, endogenous BMP signaling is necessary for normal bone regeneration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Bone and Mineral Research
volume
16
issue
3
pages
497 - 500
publisher
AMBMR
external identifiers
  • wos:000167157700009
  • scopus:0035101614
ISSN
1523-4681
DOI
10.1359/jbmr.2001.16.3.497
language
English
LU publication?
yes
id
21c475b6-e3cc-4674-b13e-10ab477dd784 (old id 1119518)
date added to LUP
2008-06-24 11:36:45
date last changed
2018-01-07 05:10:11
@article{21c475b6-e3cc-4674-b13e-10ab477dd784,
  abstract     = {Bone morphogenetic proteins (BMPs) are expressed and secreted during fracture repair. Although they are likely to be required for this process, little is known about their physiological role in bone regeneration. Noggin is a protein that specifically binds and inactivates several BMPs, It plays fundamental roles during early embryonal development and limb morphogenesis by this BMP-inactivating activity. This study shows that Noggin can modify bone formation in vivo in the adult animal and, thus, indirectly, that BMP signaling is indispensable in this process. A noggin mutein (hNg Delta B2-Fc) engineered so as to display increased bioavailability was used. Bilateral titanium bone chambers mere inserted in 70 rats, and side comparisons for bone formation in the chambers were done. The hNg Delta B2-Fc had no effect on total amount of tissue formed in the chamber but decreased the amount of bone compared with both buffer controls and a control made up of an Fc-tagged IL-6R alpha protein, which had no effects of its own, Also, wild-type noggin inhibited bone formation. Thus, endogenous BMP signaling is necessary for normal bone regeneration.},
  author       = {Aspenberg, Per and Jeppsson, Charlotte and Economides, Aris N.},
  issn         = {1523-4681},
  language     = {eng},
  number       = {3},
  pages        = {497--500},
  publisher    = {AMBMR},
  series       = {Journal of Bone and Mineral Research},
  title        = {The bone morphogenetic proteins antagonist noggin inhibits membranous ossification},
  url          = {http://dx.doi.org/10.1359/jbmr.2001.16.3.497},
  volume       = {16},
  year         = {2001},
}