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Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified delta-aminolevulinic acid

Soto Thompson, Marcelo LU ; Gustafsson, Lotta LU ; Pålsson, Sara LU ; Bendsöe, Niels LU ; Stenberg, Maria LU ; af Klinteberg, Claes; Andersson-Engels, Stefan LU and Svanberg, Katarina LU (2001) In Journal of Porphyrins and Phthalocyanines 5(2). p.147-147
Abstract
Various optical techniques were used to investigate relevant parameters involved in photodynamic therapy (PDT) of human basal cell carcinomas (BCCs). The aim of the study was to compare the diagnostic and therapeutic outcome when using topically applied methyl-esterified delta -aminolevulinic acid (ALA-ME) and delta -aminolevulinic acid (ALA). A total of 35 pathologically verified BCCs in 14 patients were investigated. A diode laser. emitting continuous light at 633 nm, was used to induce PDT. The diagnostic measurements were performed before, during, and after PDT. Laser-induced fluorescence (LIF) was used to monitor the build-up of the ALA/ALA-ME-induced protoporphyrin IX (PpIX), The superficial tissue perfusion was measured with... (More)
Various optical techniques were used to investigate relevant parameters involved in photodynamic therapy (PDT) of human basal cell carcinomas (BCCs). The aim of the study was to compare the diagnostic and therapeutic outcome when using topically applied methyl-esterified delta -aminolevulinic acid (ALA-ME) and delta -aminolevulinic acid (ALA). A total of 35 pathologically verified BCCs in 14 patients were investigated. A diode laser. emitting continuous light at 633 nm, was used to induce PDT. The diagnostic measurements were performed before, during, and after PDT. Laser-induced fluorescence (LIF) was used to monitor the build-up of the ALA/ALA-ME-induced protoporphyrin IX (PpIX), The superficial tissue perfusion was measured with laser-Doppler perfusion imaging (LDPI) and the temperature of the lesion and the surrounding tissue was imaged with an IR-camera. A clear demarcation between the lesion and the normal skin was detected with LIF before the treatment for both PpIX precursors. The fluorescence measurements suggest that PpIX builds up to a higher degree and more selectively in the tumour following ALA-ME as compared to ALA. The LDPI measurements indicate a local transient restriction in blood perfusion immediately post-PDT. The measurement with the IR-camera revealed a temperature rise of about 1-2 degreesC during the treatment. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
Journal of Porphyrins and Phthalocyanines
volume
5
issue
2
pages
147 - 147
publisher
Society of Porphyrins & Phthalocyanines
external identifiers
  • wos:000166859000006
ISSN
1099-1409
language
English
LU publication?
yes
id
8bedf8c6-e2cb-43e5-b482-0493ded3b4cd (old id 1119592)
date added to LUP
2008-07-16 10:14:53
date last changed
2018-05-29 11:48:49
@article{8bedf8c6-e2cb-43e5-b482-0493ded3b4cd,
  abstract     = {Various optical techniques were used to investigate relevant parameters involved in photodynamic therapy (PDT) of human basal cell carcinomas (BCCs). The aim of the study was to compare the diagnostic and therapeutic outcome when using topically applied methyl-esterified delta -aminolevulinic acid (ALA-ME) and delta -aminolevulinic acid (ALA). A total of 35 pathologically verified BCCs in 14 patients were investigated. A diode laser. emitting continuous light at 633 nm, was used to induce PDT. The diagnostic measurements were performed before, during, and after PDT. Laser-induced fluorescence (LIF) was used to monitor the build-up of the ALA/ALA-ME-induced protoporphyrin IX (PpIX), The superficial tissue perfusion was measured with laser-Doppler perfusion imaging (LDPI) and the temperature of the lesion and the surrounding tissue was imaged with an IR-camera. A clear demarcation between the lesion and the normal skin was detected with LIF before the treatment for both PpIX precursors. The fluorescence measurements suggest that PpIX builds up to a higher degree and more selectively in the tumour following ALA-ME as compared to ALA. The LDPI measurements indicate a local transient restriction in blood perfusion immediately post-PDT. The measurement with the IR-camera revealed a temperature rise of about 1-2 degreesC during the treatment.},
  author       = {Soto Thompson, Marcelo and Gustafsson, Lotta and Pålsson, Sara and Bendsöe, Niels and Stenberg, Maria and af Klinteberg, Claes and Andersson-Engels, Stefan and Svanberg, Katarina},
  issn         = {1099-1409},
  language     = {eng},
  number       = {2},
  pages        = {147--147},
  publisher    = {Society of Porphyrins & Phthalocyanines},
  series       = {Journal of Porphyrins and Phthalocyanines},
  title        = {Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified delta-aminolevulinic acid},
  volume       = {5},
  year         = {2001},
}