Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins
(2001) In Infection and Immunity 69(11). p.7187-7189- Abstract
- Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1119762
- author
- Collin, Mattias LU and Olsén, Arne LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Infection and Immunity
- volume
- 69
- issue
- 11
- pages
- 7187 - 7189
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:11598100
- scopus:0034773523
- pmid:11598100
- ISSN
- 1098-5522
- DOI
- 10.1128/IAI.69.11.7187-7189.2001
- language
- English
- LU publication?
- yes
- id
- 9807f2bb-e0c5-4257-a8f2-fec8dbe8b5a4 (old id 1119762)
- date added to LUP
- 2016-04-01 12:38:39
- date last changed
- 2022-04-06 01:10:54
@article{9807f2bb-e0c5-4257-a8f2-fec8dbe8b5a4, abstract = {{Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.}}, author = {{Collin, Mattias and Olsén, Arne}}, issn = {{1098-5522}}, language = {{eng}}, number = {{11}}, pages = {{7187--7189}}, publisher = {{American Society for Microbiology}}, series = {{Infection and Immunity}}, title = {{Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins}}, url = {{http://dx.doi.org/10.1128/IAI.69.11.7187-7189.2001}}, doi = {{10.1128/IAI.69.11.7187-7189.2001}}, volume = {{69}}, year = {{2001}}, }