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Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins

Collin, Mattias LU and Olsén, Arne LU (2001) In Infection and Immunity 69(11). p.7187-7189
Abstract
Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
69
issue
11
pages
7187 - 7189
publisher
American Society for Microbiology
external identifiers
  • pmid:11598100
  • scopus:0034773523
ISSN
1098-5522
DOI
10.1128/IAI.69.11.7187-7189.2001
language
English
LU publication?
yes
id
9807f2bb-e0c5-4257-a8f2-fec8dbe8b5a4 (old id 1119762)
date added to LUP
2008-06-26 09:10:54
date last changed
2018-03-25 03:40:27
@article{9807f2bb-e0c5-4257-a8f2-fec8dbe8b5a4,
  abstract     = {Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.},
  author       = {Collin, Mattias and Olsén, Arne},
  issn         = {1098-5522},
  language     = {eng},
  number       = {11},
  pages        = {7187--7189},
  publisher    = {American Society for Microbiology},
  series       = {Infection and Immunity},
  title        = {Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins},
  url          = {http://dx.doi.org/10.1128/IAI.69.11.7187-7189.2001},
  volume       = {69},
  year         = {2001},
}