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Smoking and acute myeloid leukemia: associations with morphology and karyotypic patterns and evaluation of dose-response relations

Björk, Jonas LU ; Albin, Maria LU ; Mauritzson, Nils LU ; Strömberg, Ulf LU ; Johansson, Bertil LU and Hagmar, Lars (2001) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 25(10). p.865-872
Abstract
This case-control study of tobacco smoking and acute myeloid leukemia (AML), emphasizing specific associations with morphologic and cytogenetic subtypes, comprised smoking histories for 333 cases and 351 controls. Smoking status (ever smokers versus life-long non-smokers) showed no evident effect on AML risk. However, an effect of smoking was indicated at high cumulative smoking doses (pack-years), e.g. 40 pack-years was associated with an odds ratio (OR) of 1.5 [95% confidence interval (CI) 1.0-2.3]. Among morphologic subtypes, the smoking associated OR for acute erythroleukemia was 8.9 (95% CI 1.0-76). No clear associations between smoking and cytogenetic subtypes of AML were observed.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute myeloid leukemia, Chromosomal aberrations, Dose–response, Morphology, Smoking
in
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
volume
25
issue
10
pages
865 - 872
publisher
Elsevier
external identifiers
  • pmid:11532519
  • scopus:0034893393
ISSN
1873-5835
DOI
10.1016/S0145-2126(01)00048-0
language
English
LU publication?
yes
id
0284f24d-f3e5-48fe-a6f6-50d2e4ad8988 (old id 1120220)
date added to LUP
2008-06-25 10:28:39
date last changed
2018-05-29 09:34:22
@article{0284f24d-f3e5-48fe-a6f6-50d2e4ad8988,
  abstract     = {This case-control study of tobacco smoking and acute myeloid leukemia (AML), emphasizing specific associations with morphologic and cytogenetic subtypes, comprised smoking histories for 333 cases and 351 controls. Smoking status (ever smokers versus life-long non-smokers) showed no evident effect on AML risk. However, an effect of smoking was indicated at high cumulative smoking doses (pack-years), e.g. 40 pack-years was associated with an odds ratio (OR) of 1.5 [95% confidence interval (CI) 1.0-2.3]. Among morphologic subtypes, the smoking associated OR for acute erythroleukemia was 8.9 (95% CI 1.0-76). No clear associations between smoking and cytogenetic subtypes of AML were observed.},
  author       = {Björk, Jonas and Albin, Maria and Mauritzson, Nils and Strömberg, Ulf and Johansson, Bertil and Hagmar, Lars},
  issn         = {1873-5835},
  keyword      = {Acute myeloid leukemia,Chromosomal aberrations,Dose–response,Morphology,Smoking},
  language     = {eng},
  number       = {10},
  pages        = {865--872},
  publisher    = {Elsevier},
  series       = {Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis},
  title        = {Smoking and acute myeloid leukemia: associations with morphology and karyotypic patterns and evaluation of dose-response relations},
  url          = {http://dx.doi.org/10.1016/S0145-2126(01)00048-0},
  volume       = {25},
  year         = {2001},
}