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Are occupational, hobby, or lifestyle exposures associated with Philadelphia chromosome positive chronic myeloid leukaemia?

Björk, Jonas LU ; Albin, Maria LU ; Welinder, Hans LU ; Tinnerberg, Håkan LU ; Mauritzson, Nils LU ; Kauppinen, T; Strömberg, Ulf LU ; Johansson, Bertil LU ; Billström, R and Mikoczy, Zoli LU , et al. (2001) In Occupational and Environmental Medicine1994-01-01+01:00 58(11). p.722-727
Abstract
OBJECTIVES: To investigate a broad range of occupational, hobby, and lifestyle exposures, suggested as risk factors for Philadelphia chromosome positive (Ph+) chronic myeloid leukaemia (CML). METHODS: A case-control study, comprising 255 Ph+CML patients from southern Sweden and matched controls, was conducted. Individual data on work tasks, hobbies, and lifestyle exposures were obtained by telephone interviews. Occupational hygienists assessed occupational and hobby exposures for each subject individually. Also, occupational titles were obtained from national registries, and group level exposure-that is, the exposure proportion for each occupational title-was assessed with a job exposure matrix. The effects of 11 exposures using individual... (More)
OBJECTIVES: To investigate a broad range of occupational, hobby, and lifestyle exposures, suggested as risk factors for Philadelphia chromosome positive (Ph+) chronic myeloid leukaemia (CML). METHODS: A case-control study, comprising 255 Ph+CML patients from southern Sweden and matched controls, was conducted. Individual data on work tasks, hobbies, and lifestyle exposures were obtained by telephone interviews. Occupational hygienists assessed occupational and hobby exposures for each subject individually. Also, occupational titles were obtained from national registries, and group level exposure-that is, the exposure proportion for each occupational title-was assessed with a job exposure matrix. The effects of 11 exposures using individual data and two exposures using group data (organic solvents and animal dust) were estimated. RESULTS: For the individual data on organic solvents, an effect was found for moderate or high intensity of exposure (odds ratio (OR) 3.4, 95% confidence interval (95% CI) 1.1 to 11) and for long duration (15-20 years) of exposure (OR 2.1, 95% CI 1.1 to 4.0). By contrast, the group data showed no association (OR 0.69, 95% CI 0.27 to 1.8; moderate or high intensity versus no exposure). For extremely low frequency electromagnetic fields (EMFs), only individual data were available. An association with long occupational exposure to EMFs was found (OR 2.3, 95% CI 1.2 to 4.5). However, no effect of EMF intensity was indicated. No significant effects of benzene, gasoline or diesel, or tobacco smoking were found. OR estimates below unity were suggested for personal use of hair dye and for agricultural exposures. CONCLUSIONS: Associations between exposure to organic solvents and EMFs, and Ph+CML were indicated but were not entirely consistent. (Less)
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published
subject
keywords
risk factors, epidemiology, case-control study
in
Occupational and Environmental Medicine1994-01-01+01:00
volume
58
issue
11
pages
722 - 727
publisher
BMJ Publishing Group
external identifiers
  • pmid:11600728
  • scopus:0034770909
ISSN
1470-7926
DOI
10.1136/oem.58.11.722
language
English
LU publication?
yes
id
9200c015-5d14-4b1a-9855-ec8904891e82 (old id 1120226)
date added to LUP
2008-06-25 10:25:37
date last changed
2018-01-07 09:00:38
@article{9200c015-5d14-4b1a-9855-ec8904891e82,
  abstract     = {OBJECTIVES: To investigate a broad range of occupational, hobby, and lifestyle exposures, suggested as risk factors for Philadelphia chromosome positive (Ph+) chronic myeloid leukaemia (CML). METHODS: A case-control study, comprising 255 Ph+CML patients from southern Sweden and matched controls, was conducted. Individual data on work tasks, hobbies, and lifestyle exposures were obtained by telephone interviews. Occupational hygienists assessed occupational and hobby exposures for each subject individually. Also, occupational titles were obtained from national registries, and group level exposure-that is, the exposure proportion for each occupational title-was assessed with a job exposure matrix. The effects of 11 exposures using individual data and two exposures using group data (organic solvents and animal dust) were estimated. RESULTS: For the individual data on organic solvents, an effect was found for moderate or high intensity of exposure (odds ratio (OR) 3.4, 95% confidence interval (95% CI) 1.1 to 11) and for long duration (15-20 years) of exposure (OR 2.1, 95% CI 1.1 to 4.0). By contrast, the group data showed no association (OR 0.69, 95% CI 0.27 to 1.8; moderate or high intensity versus no exposure). For extremely low frequency electromagnetic fields (EMFs), only individual data were available. An association with long occupational exposure to EMFs was found (OR 2.3, 95% CI 1.2 to 4.5). However, no effect of EMF intensity was indicated. No significant effects of benzene, gasoline or diesel, or tobacco smoking were found. OR estimates below unity were suggested for personal use of hair dye and for agricultural exposures. CONCLUSIONS: Associations between exposure to organic solvents and EMFs, and Ph+CML were indicated but were not entirely consistent.},
  author       = {Björk, Jonas and Albin, Maria and Welinder, Hans and Tinnerberg, Håkan and Mauritzson, Nils and Kauppinen, T and Strömberg, Ulf and Johansson, Bertil and Billström, R and Mikoczy, Zoli and Ahlgren, T and Nilsson, P G and Mitelman, Felix and Hagmar, L},
  issn         = {1470-7926},
  keyword      = {risk factors,epidemiology,case-control study},
  language     = {eng},
  number       = {11},
  pages        = {722--727},
  publisher    = {BMJ Publishing Group},
  series       = {Occupational and Environmental Medicine1994-01-01+01:00},
  title        = {Are occupational, hobby, or lifestyle exposures associated with Philadelphia chromosome positive chronic myeloid leukaemia?},
  url          = {http://dx.doi.org/10.1136/oem.58.11.722},
  volume       = {58},
  year         = {2001},
}