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Prognostic value of histopathological response to radiotherapy and microvessel density in oral squamous cell carcinomas

Brun, Eva LU ; Zätterström, Ulf; Kjellén, Elisabeth LU ; Wahlberg, Peter LU ; Willen, Roger; Brun, Arne LU ; Perfekt, Roland LU and Tennvall, Jan LU (2001) In Acta Oncologica 40(4). p.491-496
Abstract
The prognostic value of histopathological response to preoperative radiotherapy (50 Gy) in radically resected oral carcinomas was studied in 39 consecutive patients. Microvessel density (MVD) was evaluated for relation to radioresponse and outcome. Resected tumour tissue was examined histopathologically and response to radiotherapy was scored according to induced morphological changes. Pretreatment biopsies were stained with antibodies to von Willebrand factor to evaluate MVD in hot-spot regions, in stromal tissue and in tumour epithelial tissue. Histopathological response to radiotherapy was highly prognostic of local failures and survival (p = 0.002), though microscopic surgical radicality was obtained. In good responders to preoperative... (More)
The prognostic value of histopathological response to preoperative radiotherapy (50 Gy) in radically resected oral carcinomas was studied in 39 consecutive patients. Microvessel density (MVD) was evaluated for relation to radioresponse and outcome. Resected tumour tissue was examined histopathologically and response to radiotherapy was scored according to induced morphological changes. Pretreatment biopsies were stained with antibodies to von Willebrand factor to evaluate MVD in hot-spot regions, in stromal tissue and in tumour epithelial tissue. Histopathological response to radiotherapy was highly prognostic of local failures and survival (p = 0.002), though microscopic surgical radicality was obtained. In good responders to preoperative radiotherapy, the 5-year survival rate was 68% compared with 24% in poor responders. In 12 patients with local recurrence after radical surgery, 11 had poor histopathological radiotherapy responses. In univariate analysis, a high MVD score in tumour epithelium was associated with poor clinical outcome but MVD did not correlate with histopathological radiotherapy response. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
40
issue
4
pages
491 - 496
publisher
Taylor & Francis
external identifiers
  • pmid:11504309
  • scopus:0034922115
ISSN
1651-226X
DOI
10.1080/02841860117077
language
English
LU publication?
yes
id
2a7645ed-2dd2-4dc0-a180-73a5b8664987 (old id 1120752)
date added to LUP
2008-06-25 14:10:04
date last changed
2018-05-29 09:56:36
@article{2a7645ed-2dd2-4dc0-a180-73a5b8664987,
  abstract     = {The prognostic value of histopathological response to preoperative radiotherapy (50 Gy) in radically resected oral carcinomas was studied in 39 consecutive patients. Microvessel density (MVD) was evaluated for relation to radioresponse and outcome. Resected tumour tissue was examined histopathologically and response to radiotherapy was scored according to induced morphological changes. Pretreatment biopsies were stained with antibodies to von Willebrand factor to evaluate MVD in hot-spot regions, in stromal tissue and in tumour epithelial tissue. Histopathological response to radiotherapy was highly prognostic of local failures and survival (p = 0.002), though microscopic surgical radicality was obtained. In good responders to preoperative radiotherapy, the 5-year survival rate was 68% compared with 24% in poor responders. In 12 patients with local recurrence after radical surgery, 11 had poor histopathological radiotherapy responses. In univariate analysis, a high MVD score in tumour epithelium was associated with poor clinical outcome but MVD did not correlate with histopathological radiotherapy response.},
  author       = {Brun, Eva and Zätterström, Ulf and Kjellén, Elisabeth and Wahlberg, Peter and Willen, Roger and Brun, Arne and Perfekt, Roland and Tennvall, Jan},
  issn         = {1651-226X},
  language     = {eng},
  number       = {4},
  pages        = {491--496},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Prognostic value of histopathological response to radiotherapy and microvessel density in oral squamous cell carcinomas},
  url          = {http://dx.doi.org/10.1080/02841860117077},
  volume       = {40},
  year         = {2001},
}