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Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation, particularly in antrum mucosa: an extension of an 18-year follow-up study of chronic gastritis in Saaremaa, Estonia

Vorobjova, Tamara; Ananieva, Olga; Maaroos, Heidi-Ingrid; Sipponen, Pentti; Villako, Kaljo; Utt, Meeme LU ; Nilsson, Ingrid; Wadström, Torkel LU and Uibo, Raivo (2001) In Pathogens and Disease 30(2). p.143-149
Abstract
Helicobacter pylori is a cause of chronic gastritis and leads to development of atrophy in some cases. There is evidence that the heat shock protein 60 (HSP60) of H. pylori is involved in induction of chronic inflammation. Seroprevalence of IgG antibodies to H. pylori HSP60 in an adult cohort from Saaremaa, Estonia (68 persons, median age 57 years), with a high prevalence of antibodies to cell surface proteins of H. pylori (92%) and a well characterized dynamics of chronic gastritis in an 18-year follow-up study, was tested using purified H. pylori HSP60 at a concentration of 1 microg ml(-1) with ELISA. The state of the gastric mucosa and the presence of H. pylori in histological sections in the samples of 1979 and 1997 were assessed in... (More)
Helicobacter pylori is a cause of chronic gastritis and leads to development of atrophy in some cases. There is evidence that the heat shock protein 60 (HSP60) of H. pylori is involved in induction of chronic inflammation. Seroprevalence of IgG antibodies to H. pylori HSP60 in an adult cohort from Saaremaa, Estonia (68 persons, median age 57 years), with a high prevalence of antibodies to cell surface proteins of H. pylori (92%) and a well characterized dynamics of chronic gastritis in an 18-year follow-up study, was tested using purified H. pylori HSP60 at a concentration of 1 microg ml(-1) with ELISA. The state of the gastric mucosa and the presence of H. pylori in histological sections in the samples of 1979 and 1997 were assessed in accordance with the Sydney system. Seropositivity for H. pylori HSP60 was 65%. Immunological response to H. pylori HSP60 is associated with the morphological presence of H. pylori in the antrum and corpus (P=0.01) and is strongly correlated with the grade of chronic inflammation, particularly in the antrum mucosa (r=0.34; P=0.003; OR=5.97 (95% CI 1.21-29.3)), but is not associated with development of atrophy during 18 years of follow-up, or with the activity of gastritis. This finding supports the evidence that immunological response to H. pylori HSP60 may play a role in triggering of the inflammatory process in the gastric mucosa. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pathogens and Disease
volume
30
issue
2
pages
143 - 149
publisher
Wiley-Blackwell
external identifiers
  • pmid:11267848
  • scopus:0035071391
ISSN
2049-632X
DOI
10.1016/S0928-8244(00)00249-2
language
English
LU publication?
yes
id
ca664e38-062b-47d8-841a-cf07395b28ae (old id 1120971)
date added to LUP
2008-07-17 10:18:00
date last changed
2018-01-07 05:34:55
@article{ca664e38-062b-47d8-841a-cf07395b28ae,
  abstract     = {Helicobacter pylori is a cause of chronic gastritis and leads to development of atrophy in some cases. There is evidence that the heat shock protein 60 (HSP60) of H. pylori is involved in induction of chronic inflammation. Seroprevalence of IgG antibodies to H. pylori HSP60 in an adult cohort from Saaremaa, Estonia (68 persons, median age 57 years), with a high prevalence of antibodies to cell surface proteins of H. pylori (92%) and a well characterized dynamics of chronic gastritis in an 18-year follow-up study, was tested using purified H. pylori HSP60 at a concentration of 1 microg ml(-1) with ELISA. The state of the gastric mucosa and the presence of H. pylori in histological sections in the samples of 1979 and 1997 were assessed in accordance with the Sydney system. Seropositivity for H. pylori HSP60 was 65%. Immunological response to H. pylori HSP60 is associated with the morphological presence of H. pylori in the antrum and corpus (P=0.01) and is strongly correlated with the grade of chronic inflammation, particularly in the antrum mucosa (r=0.34; P=0.003; OR=5.97 (95% CI 1.21-29.3)), but is not associated with development of atrophy during 18 years of follow-up, or with the activity of gastritis. This finding supports the evidence that immunological response to H. pylori HSP60 may play a role in triggering of the inflammatory process in the gastric mucosa.},
  author       = {Vorobjova, Tamara and Ananieva, Olga and Maaroos, Heidi-Ingrid and Sipponen, Pentti and Villako, Kaljo and Utt, Meeme and Nilsson, Ingrid and Wadström, Torkel and Uibo, Raivo},
  issn         = {2049-632X},
  language     = {eng},
  number       = {2},
  pages        = {143--149},
  publisher    = {Wiley-Blackwell},
  series       = {Pathogens and Disease},
  title        = {Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation, particularly in antrum mucosa: an extension of an 18-year follow-up study of chronic gastritis in Saaremaa, Estonia},
  url          = {http://dx.doi.org/10.1016/S0928-8244(00)00249-2},
  volume       = {30},
  year         = {2001},
}