Advanced

Two BRCA1-positive epithelial ovarian tumors with metastases to the central nervous system: a case report

Koul, Anjila LU ; Loman, Niklas LU ; Malander, Susanne LU ; Borg, Åke LU and Ridderheim, Mona LU (2001) In Gynecologic Oncology 80(3). p.399-402
Abstract
BACKGROUND: Cerebral metastasis secondary to ovarian cancer is a rare phenomenon. While no clear relationship to known prognostic factors is found, others suggest this as a biologically diverse behavior of ovarian cancer. CASES: In a pilot study, 37 invasive epithelial ovarian cancer samples were analyzed to detect the frequency of BRCA1/BRCA2 mutations in the south of Sweden (results published). A retrospective follow-up revealed that 2 of these (2/37; 5.4%) patients developed central nervous system metastases during the course of their disease. Both patients had advanced surgical stage disease at the time of diagnosis, with histopathological serous type tumors that were negative for estrogen and progesterone receptors. One of these... (More)
BACKGROUND: Cerebral metastasis secondary to ovarian cancer is a rare phenomenon. While no clear relationship to known prognostic factors is found, others suggest this as a biologically diverse behavior of ovarian cancer. CASES: In a pilot study, 37 invasive epithelial ovarian cancer samples were analyzed to detect the frequency of BRCA1/BRCA2 mutations in the south of Sweden (results published). A retrospective follow-up revealed that 2 of these (2/37; 5.4%) patients developed central nervous system metastases during the course of their disease. Both patients had advanced surgical stage disease at the time of diagnosis, with histopathological serous type tumors that were negative for estrogen and progesterone receptors. One of these patients carried a germline BRCA1 mutation, whereas a somatic BRCA1 mutation was identified in the other patient. CONCLUSIONS: To the best of our knowledge the molecular genetic profile of these tumors is not found in the literature and it is suggested that such analyses could provide some insight for a better understanding of this rare phenomenon. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BRCA1 mutation, ovarian tumor, CNS
in
Gynecologic Oncology
volume
80
issue
3
pages
399 - 402
publisher
Academic Press
external identifiers
  • pmid:11263939
  • wos:000167422500013
  • scopus:0035096159
ISSN
1095-6859
DOI
10.1006/gyno.2000.6085
language
English
LU publication?
yes
id
f41d5cf8-d434-4e43-9d6f-d0541aa5b4f8 (old id 1121221)
date added to LUP
2008-07-01 14:55:52
date last changed
2018-04-15 03:38:57
@article{f41d5cf8-d434-4e43-9d6f-d0541aa5b4f8,
  abstract     = {BACKGROUND: Cerebral metastasis secondary to ovarian cancer is a rare phenomenon. While no clear relationship to known prognostic factors is found, others suggest this as a biologically diverse behavior of ovarian cancer. CASES: In a pilot study, 37 invasive epithelial ovarian cancer samples were analyzed to detect the frequency of BRCA1/BRCA2 mutations in the south of Sweden (results published). A retrospective follow-up revealed that 2 of these (2/37; 5.4%) patients developed central nervous system metastases during the course of their disease. Both patients had advanced surgical stage disease at the time of diagnosis, with histopathological serous type tumors that were negative for estrogen and progesterone receptors. One of these patients carried a germline BRCA1 mutation, whereas a somatic BRCA1 mutation was identified in the other patient. CONCLUSIONS: To the best of our knowledge the molecular genetic profile of these tumors is not found in the literature and it is suggested that such analyses could provide some insight for a better understanding of this rare phenomenon.},
  author       = {Koul, Anjila and Loman, Niklas and Malander, Susanne and Borg, Åke and Ridderheim, Mona},
  issn         = {1095-6859},
  keyword      = {BRCA1 mutation,ovarian tumor,CNS},
  language     = {eng},
  number       = {3},
  pages        = {399--402},
  publisher    = {Academic Press},
  series       = {Gynecologic Oncology},
  title        = {Two BRCA1-positive epithelial ovarian tumors with metastases to the central nervous system: a case report},
  url          = {http://dx.doi.org/10.1006/gyno.2000.6085},
  volume       = {80},
  year         = {2001},
}