Extracellular nucleotides ATP and UTP induce a marked acute release of tissue-type plasminogen activator in vivo in man
(2001) In Thrombosis and Haemostasis 85(5). p.875-881- Abstract
- Extracellular nucleotides such as ATP and UTP are released by activation of platelets and ischemic tissue injury. The aim of the present study was to investigate whether ATP and UTP can induce acute tPA release from the vascular endothelium in vivo. Nine healthy subjects were studied in a perfused-forearm model during stepwise intraarterial infusions of ATP and UTP (10-200 nmol/min), and UTP during inhibition of prostanoid and NO synthesis by indomethacin and L-NMMA. ATP and UTP induced a similar and marked stimulation of forearm tPA release which increased 11- and 18-fold above baseline (p < or =0.01 for both) in conjunction with pronounced vasodilation. Neither the acute tPA release nor the vasodilation could be abrogated by NO and... (More)
- Extracellular nucleotides such as ATP and UTP are released by activation of platelets and ischemic tissue injury. The aim of the present study was to investigate whether ATP and UTP can induce acute tPA release from the vascular endothelium in vivo. Nine healthy subjects were studied in a perfused-forearm model during stepwise intraarterial infusions of ATP and UTP (10-200 nmol/min), and UTP during inhibition of prostanoid and NO synthesis by indomethacin and L-NMMA. ATP and UTP induced a similar and marked stimulation of forearm tPA release which increased 11- and 18-fold above baseline (p < or =0.01 for both) in conjunction with pronounced vasodilation. Neither the acute tPA release nor the vasodilation could be abrogated by NO and prostanoid synthesis inhibition. The similar effect of ATP and UTP suggests that P2Y rather than adenosine receptors mediate the response. Release of extracellular nucleotides in ischemic tissue may induce a pronounced activation of the endogenous fibrinolytic system. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121352
- author
- Hrafnkelsdottir, Thórdís ; Erlinge, David LU and Jern, Sverker
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis and Haemostasis
- volume
- 85
- issue
- 5
- pages
- 875 - 881
- publisher
- Schattauer GmbH
- external identifiers
-
- pmid:11372682
- scopus:0035020962
- ISSN
- 0340-6245
- language
- English
- LU publication?
- yes
- id
- 1f51b749-ff92-41ad-bca0-dbc3fc0cf7b2 (old id 1121352)
- date added to LUP
- 2016-04-01 16:33:57
- date last changed
- 2022-04-22 22:56:29
@article{1f51b749-ff92-41ad-bca0-dbc3fc0cf7b2, abstract = {{Extracellular nucleotides such as ATP and UTP are released by activation of platelets and ischemic tissue injury. The aim of the present study was to investigate whether ATP and UTP can induce acute tPA release from the vascular endothelium in vivo. Nine healthy subjects were studied in a perfused-forearm model during stepwise intraarterial infusions of ATP and UTP (10-200 nmol/min), and UTP during inhibition of prostanoid and NO synthesis by indomethacin and L-NMMA. ATP and UTP induced a similar and marked stimulation of forearm tPA release which increased 11- and 18-fold above baseline (p < or =0.01 for both) in conjunction with pronounced vasodilation. Neither the acute tPA release nor the vasodilation could be abrogated by NO and prostanoid synthesis inhibition. The similar effect of ATP and UTP suggests that P2Y rather than adenosine receptors mediate the response. Release of extracellular nucleotides in ischemic tissue may induce a pronounced activation of the endogenous fibrinolytic system.}}, author = {{Hrafnkelsdottir, Thórdís and Erlinge, David and Jern, Sverker}}, issn = {{0340-6245}}, language = {{eng}}, number = {{5}}, pages = {{875--881}}, publisher = {{Schattauer GmbH}}, series = {{Thrombosis and Haemostasis}}, title = {{Extracellular nucleotides ATP and UTP induce a marked acute release of tissue-type plasminogen activator in vivo in man}}, volume = {{85}}, year = {{2001}}, }