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Differential proteinase expression by Pseudomonas aeruginosa derived from chronic leg ulcers

Schmidtchen, Artur LU ; Wolff, Helene and Hansson, Carita (2001) In Acta Dermato-Venereologica 81(6). p.406-409
Abstract
Pseudomonas aeruginosa colonizes 20-30% of all venous leg ulcers. Hypothetically, P. aeraginosa could release proteases and cytotoxic substances in the environment of chronic ulcers, thus negatively affecting the wound-healing activity in this patient group. Here we show that P. aeruginosa isolates from leg ulcers exhibit a highly variable expression of the proteinases elastase and alkaline proteinase. We propose that bacterial phenotype should be taken into account in future studies on the clinical outcome of leg ulcers colonized by P. aeruginosa.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bacteria, Virulence, Factor, Wound, Healing
in
Acta Dermato-Venereologica
volume
81
issue
6
pages
406 - 409
publisher
Medical Journals Limited
external identifiers
  • pmid:11859942
  • scopus:0035701613
ISSN
1651-2057
DOI
10.1080/000155501317208336
language
English
LU publication?
yes
id
f9b7f78e-ed57-4004-b4eb-03361c2391ee (old id 1121494)
date added to LUP
2008-07-14 11:03:26
date last changed
2018-05-29 12:09:23
@article{f9b7f78e-ed57-4004-b4eb-03361c2391ee,
  abstract     = {Pseudomonas aeruginosa colonizes 20-30% of all venous leg ulcers. Hypothetically, P. aeraginosa could release proteases and cytotoxic substances in the environment of chronic ulcers, thus negatively affecting the wound-healing activity in this patient group. Here we show that P. aeruginosa isolates from leg ulcers exhibit a highly variable expression of the proteinases elastase and alkaline proteinase. We propose that bacterial phenotype should be taken into account in future studies on the clinical outcome of leg ulcers colonized by P. aeruginosa.},
  author       = {Schmidtchen, Artur and Wolff, Helene and Hansson, Carita},
  issn         = {1651-2057},
  keyword      = {Bacteria,Virulence,Factor,Wound,Healing},
  language     = {eng},
  number       = {6},
  pages        = {406--409},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Differential proteinase expression by Pseudomonas aeruginosa derived from chronic leg ulcers},
  url          = {http://dx.doi.org/10.1080/000155501317208336},
  volume       = {81},
  year         = {2001},
}