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Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death

Petersén, Åsa LU ; Larsen, K E; Behr, G G; Romero, N; Przedborski, S; Brundin, Patrik LU and Sulzer, D (2001) In Brain Research Bulletin 56(3-4). p.331-335
Abstract
In hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) protects striatal neurons against a variety of insults. We confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal cultures derived from postnatal mice. Furthermore, BDNF inhibited intracellular oxyradical stress triggered by dopamine, and partially blocked basal and dopamine-induced apoptosis. Nevertheless, BDNF failed to rescue striatal neurons from dopamine-induced cell death. Therefore, BDNF inhibits free radical and apoptotic pathways in medium spiny neurons, but does so downstream from the point of commitment to cell death.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Huntington’s disease, Autophagy, DARPP-32, Medium spiny neuron
in
Brain Research Bulletin
volume
56
issue
3-4
pages
331 - 335
publisher
Elsevier
external identifiers
  • pmid:11719268
  • scopus:0035503713
ISSN
0361-9230
DOI
10.1016/S0361-9230(01)00580-9
language
English
LU publication?
yes
id
921b92bc-20a5-40a9-a0b6-33570ff34050 (old id 1121754)
date added to LUP
2008-07-09 11:17:35
date last changed
2018-08-12 03:25:03
@article{921b92bc-20a5-40a9-a0b6-33570ff34050,
  abstract     = {In hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) protects striatal neurons against a variety of insults. We confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal cultures derived from postnatal mice. Furthermore, BDNF inhibited intracellular oxyradical stress triggered by dopamine, and partially blocked basal and dopamine-induced apoptosis. Nevertheless, BDNF failed to rescue striatal neurons from dopamine-induced cell death. Therefore, BDNF inhibits free radical and apoptotic pathways in medium spiny neurons, but does so downstream from the point of commitment to cell death.},
  author       = {Petersén, Åsa and Larsen, K E and Behr, G G and Romero, N and Przedborski, S and Brundin, Patrik and Sulzer, D},
  issn         = {0361-9230},
  keyword      = {Huntington’s disease,Autophagy,DARPP-32,Medium spiny neuron},
  language     = {eng},
  number       = {3-4},
  pages        = {331--335},
  publisher    = {Elsevier},
  series       = {Brain Research Bulletin},
  title        = {Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death},
  url          = {http://dx.doi.org/10.1016/S0361-9230(01)00580-9},
  volume       = {56},
  year         = {2001},
}