Advanced

Effects of inhibition of PAF, ICAM-1, and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion.

Sun, ZW; Wang, XD; Lasson, Åke LU ; Börjesson, Anna LU ; Annborn, M and Andersson, Roland LU (2001) In Scandinavian Journal of Gastroenterology 36(1). p.55-65
Abstract
BACKGROUND: The role of cell adhesion molecules and transmigration of PMNs through the endothelial barrier is probably essential in intestinal ischemia and reperfusion (I/R)-induced gut barrier dysfunction. Although cytokines are released in I/R, it is unclear whether cytokines directly increase permeability or if this phenomenon requires both expression of cell adhesion molecules and PMN adhesion-activation. Endothelial barrier dysfunction plays an important role in the pathogenesis of multiple organ dysfunction syndrome, inducing gut barrier failure, but the mechanisms are not fully understood. The purpose of this study was to evaluate the potential therapeutic value of inhibition of platelet activating factor (PAF), intercellular... (More)
BACKGROUND: The role of cell adhesion molecules and transmigration of PMNs through the endothelial barrier is probably essential in intestinal ischemia and reperfusion (I/R)-induced gut barrier dysfunction. Although cytokines are released in I/R, it is unclear whether cytokines directly increase permeability or if this phenomenon requires both expression of cell adhesion molecules and PMN adhesion-activation. Endothelial barrier dysfunction plays an important role in the pathogenesis of multiple organ dysfunction syndrome, inducing gut barrier failure, but the mechanisms are not fully understood. The purpose of this study was to evaluate the potential therapeutic value of inhibition of platelet activating factor (PAF), intercellular adhesion molecule-1 (ICAM-1), and platelet endothelial cell adhesion molecule-1 (PECAM-1) in gut barrier dysfunction induced by intestinal I/R. METHODS: A PAF antagonist (lexipafant, BB-882) and monoclonal antibodies against rat ICAM-1 (anti-ICAM-1-MAb) and (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adhesion, Molecules, Barrier, Cytokine, Endothelium, Epithelium, Leukocyte, Permeability, Protease, Inhibitors
in
Scandinavian Journal of Gastroenterology
volume
36
issue
1
pages
55 - 65
publisher
Taylor & Francis
external identifiers
  • scopus:0035133344
ISSN
1502-7708
DOI
10.1080/00365520117311
language
English
LU publication?
yes
id
7f4db731-1db8-4cfc-8be4-9f607c15a227 (old id 1121838)
date added to LUP
2008-07-16 08:50:25
date last changed
2018-01-14 04:08:28
@article{7f4db731-1db8-4cfc-8be4-9f607c15a227,
  abstract     = {BACKGROUND: The role of cell adhesion molecules and transmigration of PMNs through the endothelial barrier is probably essential in intestinal ischemia and reperfusion (I/R)-induced gut barrier dysfunction. Although cytokines are released in I/R, it is unclear whether cytokines directly increase permeability or if this phenomenon requires both expression of cell adhesion molecules and PMN adhesion-activation. Endothelial barrier dysfunction plays an important role in the pathogenesis of multiple organ dysfunction syndrome, inducing gut barrier failure, but the mechanisms are not fully understood. The purpose of this study was to evaluate the potential therapeutic value of inhibition of platelet activating factor (PAF), intercellular adhesion molecule-1 (ICAM-1), and platelet endothelial cell adhesion molecule-1 (PECAM-1) in gut barrier dysfunction induced by intestinal I/R. METHODS: A PAF antagonist (lexipafant, BB-882) and monoclonal antibodies against rat ICAM-1 (anti-ICAM-1-MAb) and},
  author       = {Sun, ZW and Wang, XD and Lasson, Åke and Börjesson, Anna and Annborn, M and Andersson, Roland},
  issn         = {1502-7708},
  keyword      = {Adhesion,Molecules,Barrier,Cytokine,Endothelium,Epithelium,Leukocyte,Permeability,Protease,Inhibitors},
  language     = {eng},
  number       = {1},
  pages        = {55--65},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Effects of inhibition of PAF, ICAM-1, and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion.},
  url          = {http://dx.doi.org/10.1080/00365520117311},
  volume       = {36},
  year         = {2001},
}