Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal stroke
Zhao, Li Ru ; Risedal, Anette LU ; Wojcik, Aleksandra ; Hejzlar, Jan ; Johansson, Barbro LU and Kokaia, Zaal LU
(2001)
In Neuroscience Letters
305(3).
p.169-172
- Abstract
- Tissue levels of brain-derived neurotrophic factor (BDNF) protein were studied using enzyme immunoassay in different forebrain regions in the ipsi- and contralateral hemispheres of rats housed under enriched or standard conditions after the middle cerebral artery ligation. BDNF levels in the ipsilateral to ligation side was significantly higher only in the frontal cortex of standard as compared to enriched rats. However, BDNF overall was more abundant in standard than in enriched group. In addition, BDNF levels detected in the hippocampus and frontal cortex on the ischemic side of standard rats was higher as compared to contralateral side. The present study shows that housing conditions after permanent middle cerebral artery ligation leads... (More)
- Tissue levels of brain-derived neurotrophic factor (BDNF) protein were studied using enzyme immunoassay in different forebrain regions in the ipsi- and contralateral hemispheres of rats housed under enriched or standard conditions after the middle cerebral artery ligation. BDNF levels in the ipsilateral to ligation side was significantly higher only in the frontal cortex of standard as compared to enriched rats. However, BDNF overall was more abundant in standard than in enriched group. In addition, BDNF levels detected in the hippocampus and frontal cortex on the ischemic side of standard rats was higher as compared to contralateral side. The present study shows that housing conditions after permanent middle cerebral artery ligation leads to differential regulation of BDNF protein levels in forebrain regions which might have important implication for post-ischemic recovery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121938
- author
- Zhao, Li Ru
; Risedal, Anette
LU
; Wojcik, Aleksandra
; Hejzlar, Jan
; Johansson, Barbro
LU
and Kokaia, Zaal
LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuroscience Letters
- volume
- 305
- issue
- 3
- pages
- 169 - 172
- publisher
- Elsevier
- external identifiers
-
- pmid:11403932
- scopus:0035877195
- ISSN
- 0304-3940
- DOI
- 10.1016/S0304-3940(01)01837-7
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160), Neurology, Lund (013027000)
- id
- b43ed16d-f728-45ff-a92e-e3052fe4ba65 (old id 1121938)
- date added to LUP
- 2016-04-01 12:15:50
- date last changed
- 2022-02-11 04:36:48
@article{b43ed16d-f728-45ff-a92e-e3052fe4ba65,
abstract = {{Tissue levels of brain-derived neurotrophic factor (BDNF) protein were studied using enzyme immunoassay in different forebrain regions in the ipsi- and contralateral hemispheres of rats housed under enriched or standard conditions after the middle cerebral artery ligation. BDNF levels in the ipsilateral to ligation side was significantly higher only in the frontal cortex of standard as compared to enriched rats. However, BDNF overall was more abundant in standard than in enriched group. In addition, BDNF levels detected in the hippocampus and frontal cortex on the ischemic side of standard rats was higher as compared to contralateral side. The present study shows that housing conditions after permanent middle cerebral artery ligation leads to differential regulation of BDNF protein levels in forebrain regions which might have important implication for post-ischemic recovery.}},
author = {{Zhao, Li Ru and Risedal, Anette and Wojcik, Aleksandra and Hejzlar, Jan and Johansson, Barbro and Kokaia, Zaal}},
issn = {{0304-3940}},
language = {{eng}},
number = {{3}},
pages = {{169--172}},
publisher = {{Elsevier}},
series = {{Neuroscience Letters}},
title = {{Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal stroke}},
url = {{http://dx.doi.org/10.1016/S0304-3940(01)01837-7}},
doi = {{10.1016/S0304-3940(01)01837-7}},
volume = {{305}},
year = {{2001}},
}