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Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal stroke

Zhao, Li Ru; Risedal, Anette LU ; Wojcik, Aleksandra; Hejzlar, Jan; Johansson, Barbro LU and Kokaia, Zaal LU (2001) In Neuroscience Letters 305(3). p.169-172
Abstract
Tissue levels of brain-derived neurotrophic factor (BDNF) protein were studied using enzyme immunoassay in different forebrain regions in the ipsi- and contralateral hemispheres of rats housed under enriched or standard conditions after the middle cerebral artery ligation. BDNF levels in the ipsilateral to ligation side was significantly higher only in the frontal cortex of standard as compared to enriched rats. However, BDNF overall was more abundant in standard than in enriched group. In addition, BDNF levels detected in the hippocampus and frontal cortex on the ischemic side of standard rats was higher as compared to contralateral side. The present study shows that housing conditions after permanent middle cerebral artery ligation leads... (More)
Tissue levels of brain-derived neurotrophic factor (BDNF) protein were studied using enzyme immunoassay in different forebrain regions in the ipsi- and contralateral hemispheres of rats housed under enriched or standard conditions after the middle cerebral artery ligation. BDNF levels in the ipsilateral to ligation side was significantly higher only in the frontal cortex of standard as compared to enriched rats. However, BDNF overall was more abundant in standard than in enriched group. In addition, BDNF levels detected in the hippocampus and frontal cortex on the ischemic side of standard rats was higher as compared to contralateral side. The present study shows that housing conditions after permanent middle cerebral artery ligation leads to differential regulation of BDNF protein levels in forebrain regions which might have important implication for post-ischemic recovery. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscience Letters
volume
305
issue
3
pages
169 - 172
publisher
Elsevier
external identifiers
  • pmid:11403932
  • scopus:0035877195
ISSN
0304-3940
DOI
language
English
LU publication?
yes
id
b43ed16d-f728-45ff-a92e-e3052fe4ba65 (old id 1121938)
date added to LUP
2008-07-18 16:37:10
date last changed
2018-06-03 03:41:05
@article{b43ed16d-f728-45ff-a92e-e3052fe4ba65,
  abstract     = {Tissue levels of brain-derived neurotrophic factor (BDNF) protein were studied using enzyme immunoassay in different forebrain regions in the ipsi- and contralateral hemispheres of rats housed under enriched or standard conditions after the middle cerebral artery ligation. BDNF levels in the ipsilateral to ligation side was significantly higher only in the frontal cortex of standard as compared to enriched rats. However, BDNF overall was more abundant in standard than in enriched group. In addition, BDNF levels detected in the hippocampus and frontal cortex on the ischemic side of standard rats was higher as compared to contralateral side. The present study shows that housing conditions after permanent middle cerebral artery ligation leads to differential regulation of BDNF protein levels in forebrain regions which might have important implication for post-ischemic recovery.},
  author       = {Zhao, Li Ru and Risedal, Anette and Wojcik, Aleksandra and Hejzlar, Jan and Johansson, Barbro and Kokaia, Zaal},
  issn         = {0304-3940},
  language     = {eng},
  number       = {3},
  pages        = {169--172},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal stroke},
  url          = {http://dx.doi.org/},
  volume       = {305},
  year         = {2001},
}